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Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 54 - 54
1 Apr 2013
AN INJECTABLE SCAFFOLD FOR BONE TISSUE ENGINEERING
Cheng TL Valchev P Dehghani F Little DG Schindeler A
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Introduction

Bone tissue engineering approaches are an emerging strategy to treat bone defects, and commonly involve the delivery of osteogenic cells and/or drugs via a porous scaffold. We have been exploring an alternative injectable approach for drug delivery that would obviate the need for invasive surgery.

Hypothesis

Sucrose Acetate Isobutyrate (SAIB) is a sucrose-based ester that is a highly viscous semi-solid. Diluting SAIB with 10–20% ethanol markedly reduces its viscosity, with ethanol diffusing rapidly after in vivo injection. This phase transitioning property makes SAIB an ideal candidate for bone tissue engineering.