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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 205 - 205
1 Sep 2012
Renal impairment after high dose flucloxacilin and single dose gentamycin prophylaxis in patients undergoing hip and knee arthroplasty
Challagundla S Knox D Hawkins A Hamilton D Flynn R Robertson S Isles C
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Background

We switched our antibiotic prophylaxis for elective hip and knee surgery from cefuroxime to flucloxacillin with single dose gentamicin in order to reduce the incidence of C. Diff diarrhoea. More patients subsequently appeared to develop acute kidney injury (AKI).

Methods

During a twelve month period we examined the incidence of AKI sequentially in 198 patients undergoing elective hip or knee surgery: cefuroxime (n = 48); high dose flucloxacillin (median 8g) (n = 52); low dose flucloxacillin (median 4g) (n = 46); and cefuroxime again (n = 52).