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Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_4 | Pages 2 - 2
1 Feb 2017
Isaac S Gunaratne R Khan R Fick D Haebich S
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Introduction & aims

Satisfaction following total knee replacement (TKR) surgery remains suboptimal at around 80%. Prediction of factors influencing satisfaction may help manage expectations and thus improve satisfaction. We investigated preoperative variables that estimate the probability of achieving a successful surgical outcome following TKR in several outcomes important to patients.

Method

9 pre-operative variables (easily obtained on initial consultation) of 591 unilateral TKRs were selected for univariant then multivariant analyses. These variables included Oxford Knee Score (OKS), age, sex, BMI, ASA score, pain score, mobility aids, SF12 PCS & SF12 MCS. Using the relative predictive strengths of these variables we modeled the probabilities a successful result would be achieved for 6 patient reported outcomes at 3 and 12 months following surgery. These were ‘Excellent/good OKS’, ‘Mild/no pain’, ‘Walking without/at first a limp’, ‘No/little interference with normal work’, ‘Kneeling with little/no difficulty’ and ‘Satisfaction with surgery’.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_4 | Pages 28 - 28
1 Feb 2017
Isaac S Khan R Fick D Gunaratne R Haebich S
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Introduction

The risk of hip dislocation after revision total hip arthroplasty is up to 20% following surgery for periprosthetic fractures. A technique was developed by the senior authors, involving a transtrochanteric osteotomy and superior capsulotomy to attempt to minimise this risk(1).

Methods

This prospective study examines a cohort of 40 patients undergoing this novel technique, which involves extending the fracture proximally to the tip of the greater trochanter. This is then extended into the soft tissues in the mid lateral plane as a split of the glutei and a minimally superior capsulotomy (preserving the anterior and posterior capsule). This allows for revision of the femoral component, and retention of the socket and liner. The outcomes of interest to the authors were dislocation rates, clinical outcome measured using the Oxford hip score. These were assessed along with X-ray imaging at 1, 2 and 5-year intervals to confirm fracture union and measure stem subsidence.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 77 - 77
1 Jan 2013
Isaac S Shyamsunder S Palan J Esler C
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Introduction

The optimal treatment for isolated patello-femoral arthritis is unclear. Patello-femoral arthroplasty (PFA) may offer superior knee function in isolated patello-femoral osteoarthritis compare to TKA. The literature is controversial for patient outcomes in PFA. Some reports showed improved outcomes while others were disappointing. We assessed our outcomes to try to identify causes for poor outcomes.

Methods

The Trent Arthroplasty was established in 1990 to collect prospective data on knee arthroplasty surgery. Data is entered by surgeons at the time of surgery, with patient consent. PFA constitute less than 1% of the arthroplasties performed in this region. Patients were sent self-administered outcome forms 1 year post-op. Re-operation and revision procedures were reported. 334 PFA have been registered from 17 hospitals. 79% were female patients with 43% of the patients aged 55 years or less, suggesting dysplasia as the cause of their osteoarthritis. Age range 28–94 yrs (SD 11.8 yrs). The implants were Stryker Avon 236, Corin Leicester 47, Link Lubinus 24, Smith & Nephew Journey 10, DePuy LCS 7, Wright FPV 2, other 8.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 295 - 295
1 Jul 2011
Isaac S Dias J Gaur A
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Introduction: Diabetes mellitus is a systemic disease affecting peripheral nerves and the use of regional anaesthesia in diabetic patients undergoing surgery could be unpredictable. We investigated the efficacy of brachial plexus block in diabetic patients undergoing upper limb surgery compared to normal individuals.

Method: Four hundred and fifty-two patients had a brachial plexus block performed under ultra-sound guidance by senior anaesthetists. There were 221 males and 231 females. Fifty-five patients were diabetic (mean age of 61 years, SD 12), 24 with type 1 and 31 with type 2 diabetes. Mean age of non-diabetic patients was 55 years (SD 15). A mixture of 0.5% Bupivacaine and 1% Prilocaine was used for the block. Post-operative proximal and distal motor and sensory functions were assessed. The assessment was conducted at a mean of 4.6 hours (SD 2.2 hours) post-operatively. MRC grading system was used to asses motor function while sensory function was assessed subjectively using a graded scale between 0, absent sensation, 1, altered sensation and 2, normal sensation.

Results: Brachial plexus block was as efficient in diabetic patients proximally for motor and sensory functions compared to non-diabetic patients. There was significant difference in the efficacy of the block distally between diabetic and non-diabetic patients in both motor (P< 001) and sensory function (P< 0001). Furthermore, in diabetic patients the response to the block between type 1 and type 2 was statistically significant (P< 001).

Conclusion: In diabetes, the efficacy of brachial plexus block is different compared to normal individuals. This study showed that brachial plexus block can be used efficiently in shoulder surgery in patients with diabetes. In more distal surgery, orthopaedic surgeons as well as anaesthetists should be prepared to either reinforce the block by using a local anaesthetic or to convert to general anaesthesia, if necessary, in diabetic patients.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 313 - 313
1 Jul 2011
Isaac S West S
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Introduction: Dr Foster data presents mortality rate for fracture neck of femur in acute trusts. We assessed the accuracy of this data in an acute trust in England for a nine-month period.

Methods: Fifty-seven patients (17.2%) died due to fracture NOF during our review period according to Dr Foster. Medical notes were retrospectively analysed in detail. There were 20 males with a mean age of 84.5yrs (64–100) and 37 females with a mean age of 85.7yrs (57–100). Data analysis included time and day of admission, admission ward, senior orthopaedic review, anaesthetic review, ASA grade, time to surgery, grade of anaesthetist and operating surgeon, type of anaesthesia, time of anaesthesia and surgery, type of surgery, post-op recovery and cause of death.

Results: Seven patients died before their planned surgery due to extensive medical co-morbidity and 50 patients (15.1%) underwent surgery as planned. Thirty-one patients (9.4%) died under the care of the orthopaedic team and were considered by the assessors to be true death due to fracture neck of femur. Eleven patients (3.3%) died in the community after discharge home some several months later. Eight patients (2.4%) died under the care of the rehabilitation team, some months later, the majority from medical causes. The mean time to surgery was 2.7 days (0–13), which was mainly affected by weekend admissions. There were no records of the cause of death in 20 patients including all those that were discharged to the community. Admission time, ward and type and duration of anaesthesia had no effect on mortality rate.

Conclusion: In our review Dr Foster overestimated true death rate due to fracture neck of femur. This trend is worrying as such indicators are linked to financial and performance targets for trusts. Accurate data presentation is therefore imperative and Dr Foster does not appear to deliver this.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 313 - 313
1 Jul 2011
Gulihar A Isaac S Taylor G
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Background: Dr Foster’s Good Hospital Guide 2005–2006 ranked University Hospitals of Leicester NHS Trust amongst the worst in UK for in-hospital mortality and time to theatre in hip fracture patients. The problem had been recognized in early 2005 and the Fracture Neck of Femur (FNOF) project was launched. This included an increase in trauma coordinators and clinical aides, regular orthogeriatric input, daily hip fracture operating lists, a separate hip fracture ward and a dedicated discharge nurse.

Aim: The aim of this study was to assess the outcome of the FNOF project.

Method: Data on mortality and length of stay was collected from the IM& T department and was cross referenced with the PCT database. Time to theatre data was collected from the trauma coordinators. Study period was five years from January 2003 to December 2007.

Results: 3636 patients were admitted with a hip fracture in the five year period. The length of stay reduced from 31 days in 2005 to 19 days in 2007 (p< 0.001). The in-hospital mortality reduced from 17.0 % in 2005 to 11.3% in 2007 (p< 0.01). 1 year mortality dropped from 36.9% to 27.3% (p< 0.001). The 30 day and 4 month mortality were also reduced but this was not statistically significant. 85% of patients had surgery within 48 hours in 2007 as compared to 47% in 2005–06.

Conclusions: The FNOF project was successful in reducing In-hospital and 1 year mortality, length of stay and time to theatre. However, the 30 day mortality did not show a significant reduction. In-hospital mortality is not a good comparator of hospital performance as it depends on length of stay; 30 day mortality would be more accurate. The national hip fracture database can be used to obtain accurate data for future studies.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 178 - 178
1 May 2011
Isaac S Dias J Gaur A
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Introduction: Diabetes mellitus is a systemic disease that is known to affect peripheral nerves. The use of regional anaesthesia in diabetic patients undergoing surgery could be unpredictable. We investigated the efficacy of brachial plexus block in diabetic patients undergoing upper limb surgery compared to normal individuals.

Methods: Four hundred and fifty-two patients were included in the study. There were 221 males and 231 females. Fifty-five patients were diabetic (mean age of 61ys, SD 12), 24 were type 1 and 31 were type 2 diabetes. Mean age of non-diabetic patients was 55 (SD15). Senior Anaesthetists performed all brachial plexus block under ultra-sound guidance. A mixture of 10 ml of 0.5% Bupivacaine and 10 ml of 1% Xilocaine was used for the block. Post-operative motor and sensory function assessment was conducted at a mean time of 4.57 hours (SD 2.19 hours). MRC grading system was used to asses motor function while sensory function was assessed subjectively using a graded scale between 0 and 2 with 0 being absent sensation, 1 being altered sensation and 2 indicated normal sensations. The assessment was conducted proximally and distally.

Results: Brachial plexus block was as efficient in diabetic patients proximally for motor and sensory functions compared to non-diabetic patients. There was significant difference in the efficacy of the block distally between diabetic and non-diabetic patients in both motor (P< .001) and sensory function (P< .001). Furthermore, in diabetic patients the response to the block between type 1 and type 2 was statistically significant (P< .001).

Conclusion: Diabetic patients are at increased morbidity and mortality risks following general anaesthesia and therefore, regional block is a favorable option in these patients. In diabetes, the efficacy of brachial plexus block is different compare to normal individuals. This study showed that brachial plexus block can be used efficiently in shoulder surgery in patients with diabetes. In more distal surgery, orthopaedic surgeons as well as anaesthetists should be prepared to either reinforce the block by using a local anaesthetic or to convert to general anaesthesia, if necessary, in diabetic patients


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 548 - 548
1 Oct 2010
Gulihar A Bryson D Isaac S Taylor G
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Background: A good hospital guide published in 2006 identified high in-hospital mortality rates in fracture neck of femur patients at the University Hospitals of Leicester NHS trust. The trust was identified as the worst in the country in terms of the percentage of patients having surgery within the recommended 48 hours from admission. The problem had already been identified and a ‘Fracture Neck of femur project’ was launched in January 2006 to improve outcomes in these patients. This included the introduction of trauma coordinators and clinical aides who prepared patients for surgery, a separate fracture neck of femur ward, a discharge nurse, dedicated hip fracture lists and pre and post operative orthogeriatric input.

Aim: The aim of this study was to assess the impact of the fracture neck of femur project.

Methods: Data on admissions, time to theatre, length of stay and mortality was collected for 3400 patients admitted with fracture neck of femur between January 2003 and September 2007. Mortality rates, length of stay and time to theatre were compared before and after the introduction of the fracture neck of femur project.

Results: The length of stay reduced from 32 days to 18 days in 2007 (p< 0.01). The in-hospital mortality reduced from 16.6 % in 2003 to 10.7% in 2007 (p< 0.01). 30 day mortality showed a minor reduction from 12.4% in 2003 to 11.4% in 2007 (p=0.6). 95% of patients had surgery within 48 hours as compared to 47% in 2005–06 and 85% in 2006–07.

Conclusions: The high in-hospital mortality rates were reduced. The length of stay was also reduced by effective discharge planning. Measures to reduce time to theatre were highly successful. However, the 30 day mortality did not show a significant reduction. We conclude that in hospital mortality is not a good comparator of hospital performance. 30 day mortality would be more accurate.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 157 - 157
1 Mar 2008
Barker K Isaac S Danial I Beard D Gill H Gibbons C Dodd C Murray D
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Proprioception protects joints against injurious movements and is critical for joint stability maintenance under dynamic conditions. Knee replacement effect on proprioception in general remains elusive. This study aimed to evaluate the changes in proprioceptive performance after knee replacement; comparing Total (TKA) to Unicompartmental Knee Arthroplasty (UKA).

Thirty-four patients with osteoarthritis were recruited; 15 patients underwent TKA using the AGC prosthesis and 19patients underwent UKA using the Oxford prosthesis. Both cruciate ligaments were preserved in the UKA group, while only the PCL was preserved in TKA patients. Patients’ age was similar in both groups.> Joint Position Sense (JPS) and postural sway were used as measures of proprioception. Both groups were assessed pre- and 6 months post-operatively in both limbs. JPS was measured as the error in actively and passively reproducing five randomly ordered knee flexion angles between 30 and 70°using an isokinetic dynamometer. Postural sway (area and path) was measured during single leg stance using a Balance Performance Monitor. Functional outcome was assessed using the Oxford Knee Score (OKS).

Pre-operatively, no differences in JPS or sway were found between limbs in either group. No differences existed between the two groups. Post-operatively, both groups had significant improvement of JPS in the operated limb (UKA mean4.64°, SD1.44° and TKA mean5.18°, SD1.35°). No changes in JPS were seen in the control side. A significant improvement (P< 0.0001) in sway area and path was found in the UKA group only in both limbs. No significant changes in sway occurred in either limb of TKA patients. The OKS improved from 21.4 to 35.5 for TKA patients and from 23.9 to 38for UKA patients.

Both UKA and TKA improve proprioception as assessed by JPS. However, UKA alone improves postural sway in both limbs. This may impart explain why UKA patients function better than TKA patients


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 385 - 385
1 Oct 2006
Fawzy E Mandellos G Isaac S Pandit H Gundle R De Steiger R Murray D McLardy-Smith P
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Aim: To investigate the functional and radiological outcome of shelf acetabuloplasty in adults with significantly symptomatic acetabular dysplasia, with a minimum of a 5 year follow-up.

Material and Methods: 77 consecutive shelf procedures (68 patients) with an average follow-up of 10.9 years (range: 6–14) were reviewed. The Oxford hip score (OHS) was used for clinical assessment. Centre-edge angle (CEA) and acetabular angle (AA) were measured as indicators of joint containment. The severity of osteoarthiritis was based primarily on the extent of joint space narrowing. Survivorship analyses using conversion to THR as an endpoint were performed. Logrank tests were used to compare the survivorship of the shelf procedure against the variables of age, preoperative osteoarthiritis, pre and postoperative AA, CEA angles.

Results: The average age at time of surgery was 33 years (range: 17–60). At the time of the last follow-up, the mean OHS was 34.6 (maximum score: 48). Mean postoperative CEA was 55 (Pre-operatively: 13 degrees) while mean postoperative AA was 31 (Pre-operatively: 48 degrees). Thirty percent of hips needed THR at an average duration of 7.3 years. The survival in the 45 patients with only slight or no joint space narrowing was 97% (CI, 93%–100%) at 5 years and 80% (CI, 56%–100%) at 10 years. This was significantly higher (p= 0.0007) than the survival in the 32 patients with moderate or severe osteoarthiritis, which was 72% (CI, 55%–89%) at 5 years and 29% (CI, 13%–45%) at 10 years. There was no significant relationship between survival and age, pre and postoperative AA, CEA angles (p> 0.05).

Conclusion: Shelf-acetabuloplasty offers symptomatic relief to adults with acetabular dysplasia but overall deteriorates with time. About 50% of the patients do not need THR for over 10 years. Best results with shelf-acetabuloplasty were achieved in patients with slight or no joint narrowing.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 387 - 388
1 Oct 2006
Isaac S Barker K Danial I Beard D Gill H Gibbons C Dodd C Murray D
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Introduction: Knee joint arthroplasty (total or unicompartmental) is the standard operative treatment for osteoarthritis (OA). Survival rate is good for both types but functional outcome is different. The function of unicompartmental knee arthroplasty (UKA) is substantially better than that of total knee arthroplasty (TKA). As function can be strongly influenced by proprioceptive ability, it is possible that improved outcome seen in patients with UKA results from retaining proprioceptive function associated with the cruciate ligaments. This prospective longitudinal study aimed to evaluate the change in proprioceptive performance after knee replacement; comparing TKA to UKA.

Methods and Materials: Two groups of patients with OA as diagnosed clinically and by X-ray were recruited. Group 1 consisted of 15 patients (mean age 65.8 years range 57–72 years, 10 females and 5 males) listed for TKA with the AGC prosthesis (Biomet, UK). Group 2 consisted of 19 patients (mean age 65.5 years range 52–75 years; 9 females and 10 males) listed for UKA with the Oxford UKA (Biomet, UK) for medial compartment OA. The ACL and PCL were present and preserved in all patients in Group 2, while only the PCL was preserved in Group 1 patients. Joint Position Sense (JPS) and postural sway were used as measures of proprioception performance. Both groups were assessed pre-and 6 months post-operatively in both limbs. JPS was measured using a dynamometer (KinCom, Chatanooga Ltd) as the error in actively and passively reproducing five randomly ordered knee flexion angles (30°, 40°, 50°, 60° and 70°). Postural sway (area, path and velocity) was measured during single leg stance using a Balance Performance Monitor (SMS Medical) for 30 seconds interval. Functional outcome was assessed using the Oxford Knee Score (OKS).

Results: Pre-operatively, no differences in JPS or sway were found between limbs in either group. No differences existed between the two groups. Post-operatively, both groups had significant improvement of JPS in the operated limb only (Mean ± standard deviation for UKA 4.64±1.44° and for TKA 5.18±1.35°). No changes in JPS were seen in the control side. An improvement in sway was found in the UKA group only. UKA patients showed significant improvement in both sway area and path (p< .0001) for both limbs post-operatively. No significant post-operative changes in sway occurred in either limb of TKA patients. The OKS improved postoperatively in both groups, rising from 21.4 to 35.5 for TKA patients and from 23.9 to 38 for UKA patients.

Conclusion: Interestingly, joint position sense improved for both groups but did not seem to show any difference between UKA and TKA. Postural sway was influenced by joint replacement type. Ligament retention may contribute to improved global postural control seen after unicompartmental knee arthroplasty and may explain the higher level of function seen in these patients.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_IV | Pages 441 - 441
1 Apr 2004
Pandit H Beard D Jenkins C Isaac S Lisowski L Abidien Z Keyes G Lisowski A Fievez A Gill HS Dodd C Murray D
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Introduction: Oxford Unicompartmental knee arthroplasty (UKA) is now performed using a minimally invasive surgical (MIS) technique. Although early results are encouraging, the studies assessing outcome could be criticised for the restricted number of patients and centres involved. A multi-centre follow-up of patients is required to confirm the preliminary findings.

Aim: To examine early clinical outcome in patients with minimally invasive Oxford medial UKA using a multi-centre, multi-surgeon design.

Materials and Methods: This prospective study was carried out in three centres with involvement of six surgeons. All patients undergoing cemented Oxford UKA for medial OA using MIS were included. 231 consecutive UKAs with a minimum follow up of 2 years (mean: 2.84) were assessed using objective and functional Knee Society Score (KSS).

Results: There were 108 females and 102 males (21-bilateral) with average age of 66.8 years (42 – 86). No significant difference was noted between various age groups or between different surgeons. Three knees were revised: one for infection, one for unexplained pain and one for bearing dislocation. Cumulative survival rate at 2 years was 98.6% with 93% patients having good or excellent KSS rating.

Conclusions: This multi-centre study has confirmed preliminary findings that Oxford UKA using a minimally invasive approach is safe and effective.