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Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_2 | Pages 90 - 90
1 Mar 2021
Mahatma M Jayasuriya R Gossiel F Gallagher O Hughes D Buckley S Gordon A Hamer A Tomouk M Wilkinson JM
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Abstract

Objective

In this phase 2 clinical trial (EudraCT 2011-000541-20) we examined the effect of denosumab versus placebo on osteolytic lesion activity in patients undergoing revision surgery after THA.

Methods

Men and women ≥ 30 years old scheduled for revision surgery for symptomatic, radiologically-confirmed osteolysis were randomised (1:1) to receive either denosumab 60mg or placebo subcutaneously eight weeks prior to operation. At surgery, biopsies from the osteolytic membrane-bone interface were taken for histomorphometric analysis of osteoclast number, the primary outcome measure. Secondary outcome measures included other static histomorphometric indices and systemic bone turnover markers. Adverse events and patient-reported clinical outcome scores were recorded as safety endpoints.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_9 | Pages 1 - 1
1 Feb 2013
Lancaster S Clark D Redpath Y Hughes D Lewis S Crowther M
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Blockade of the suprascapular nerve (SSN) with local anaesthetic is used frequently in shoulder surgery and for chronic shoulder pain. Anatomical landmarks may be used to locate the nerve prior to infiltration with local anaesthetic, but ultrasound is becoming a popular to locate the nerve.

Twelve cadaveric shoulders from 6 specimens were injected with dye using the landmark and ultrasound technique. The shoulders were scanned with computed tomography, and then dissected to ascertain the accuracy of each technique.

Using CT scan results, we found the ultrasound group to be more accurate in placing the anaesthetic needle close to the suprascapular notch, and therefore nerve, and this was significant (p = 0.0009). When analysing the ink data, although we did not observe a significant difference in amount of nerve covered by ink, we did note a correlation, and, given this study group is small, that may be considered a statistical trend.

This study, which is one of the largest cadaveric studies investigating landmark and ultrasound guided block of the suprascapular nerve and we believe the first to use CT, demonstrates that ultrasound guided block is significantly more accurate than the landmark technique, and would therefore recommend that ultrasound guidance be used when blocking the suprascapular nerve, given its higher accuracy and lower complication rate.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXVI | Pages 62 - 62
1 Jun 2012
Hughes D Hutchinson J Nelson I Harding I
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Computer assisted surgery is becoming more prevalent in spinal surgery with most published literature suggesting an improvement in accuracy and reduction in radiation exposure. This has been particularly highlighted in scoliosis surgery with regard to the placement of pedicle screws. Anecdotally this has been challenged with concerns with regard to the steep learning curve using this equipment and the high cost of purchasing said systems. The more traditional technique utilises the surgeon's knowledge of anatomic landmarks and tactile palpation added with fluoroscopy to place pedicle screws. We retrospectively looked at 161 scoliosis corrections performed using this technique over three years by 3 main surgeons at the same centre (Frenchay). With an average of 10 levels per procedure and over 2000 pedicle screws inserted. We reviewed the radiation time exposure and dose of radiation given during each case. Our results compared favourably to published data using computer and robot assisted surgery with an average exposure time of 80 seconds and a mean dose of 144 mGy using a standard C-arm guided fluoroscopy. Our study suggests that armed with good surgical knowledge and technique it is possible to obtained low levels of radiation exposure of benefit to both patient and the operating team.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 77 - 77
1 Mar 2009
Bhansali H Hughes D Purbach B Kay P
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Introduction: There is an increasing trend for autologous blood transfusion in hip and knee replacement and we therefore felt the need to properties of the fluid reinfused.

Objectives of the study: The study objective was to determine the volume and Haemoglobin content of the reinfused blood.

Materials and methods: We prospectively studied 108 patients with primary Hip and knee arthroplasty. The drained blood was reinfused within 6 hours as recommended by the manufacturer. The volume of the drained and reinfused fluid was measured in millilitres.. The Haemoglobin (Hb.) of the patient was measured preoperatively and postoperatively in recovery. The Hb. of the drained blood and reinfused blood were also measured.

Results : The mean volume of the drained blood in the hip replacement group was 180.6 ml. while that of the reinfused blood was 132.7 ml. The mean volume of the drained blood in the knee group was 372.78 ml. while that of the reinfused blood was 362.76 ml.

The mean Haemoglobin of the reinfused blood in the hip group was 6.9 gm/dl significantly lower (p< 0.05) than the drained blood Hb. of 10.9. Similarly the Haemoglobin of the blood reinfused in knee replacements was significantly lower at 6.8 gm/dl. (p< 0.001). This was less than half of the average Hb. content of homologous blood transfusion.

Conclusion: The Haemoglobin content of the reinfused blood in Hip and knee replacement was quite low to be considered as a replacement for homologous blood transfusion and further studies may be required to confirm the efficacy of reinfusion drainage compared to homologous blood transfusion.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 335 - 335
1 Nov 2002
El-Assuity W Norris H Hughes D Persilege C Ross R
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Introduction: The Charite Mark 3 disc prosthesis has been used by the senior author for ten years. There has always been a question mark over the wear properties of the high density polyethylene spacer used in this prosthesis.

Methods: Ten patients who have received Charite implants, eight, nine and ten years ago were subjected to helical CT scanning. Slices at 3 mm. intervals were taken across the prosthetic levels. Fifteen prostheses were studied. Four clinicians, two of whom were radiologists and one a spinal fellow, assessed the CT scans against a standard protocol. Since the original heights of the prostheses were known, it was possible to measure prosthetic height and therefore get an estimate of wear. In addition, areas of osteolysis around the prostheses were estimated, again as a sign of wear.

Results: Remarkably little wear or wear debris was noted around the 15 prostheses.

Conclusions: Although this is a small series, it confirms that the medium-term performance of this prosthesis as far as wear is concerned is good.