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Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 311 - 311
1 May 2010
Sawerees E Kuiper J Griffin S Saweeres E Graham N
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Objective: The adequacy of the cement mantle around various designs of impaction-grafted stems has been compared and deemed inadequate around the Exeter system. Yet, good clinical results have been reported. The conventional wisdom of solid cement mantles has been also been questioned in recent reports by the low migration and high survival rates of stems inserted with a very thin cement mantle – the so called ‘French paradox’. We performed this study specifically to address two questions

Does cement mantle thickness affect cement penetration depth during impaction grafting? and

Does cement mantle thickness affect the early mechanical stability?

Materials and Methods: 12 composite femurs were prepared to mimic cavitary defect. Impaction grafting was done with morcellized freshly frozen porcine femoral condyles using Exeter X-change system. The size of tamp and prosthesis were independently varied creating tamp/stem mismatch to produce cement mantles with a nominal thickness of 0, 1, 2, 3 or 4 mm. Cyclical loading was done at 1 Hz for 2500 cycles at 2500 N. From the displacement data measured by 6 linear displacement transducers we calculated subsidence and retroversion. The solid cement mantle and the penetration depth into the graft were then measured along 16 points in each cut section of the femurs done at 1.5 cm intervals.

Results: There was a high correlation between tamp/stem mismatch (nominal mantle thickness) and actual mantle thickness (r=0.84). Average cement penetration into the graft for each prosthesis varied between 0.3 and 2.0 mm. Largest variations were proximally, where average penetration varied between 0.4 and 3.5 mm. A thicker solid cement mantle gave on average less cement penetration (r=−0.62). Stem subsidence after cyclic loading ranged from 0.4 to 2.5 mm and correlated significantly with tamp size (r=0.59, p< .05). However, better correlations were found with solid mantle thickness (r=0.90, p< 0.05) and cement penetration depth (r=−0.81). Stem retroversion after cyclic loading ranged from 0.1 to 2.0 degrees and correlated negatively with stem size (r=−0.53) but did not correlate with tamp size. Correlations with solid mantle thickness and cement penetration depth were not better than those with tamp size.

Discussion: Our study shows that a thinner mantle is associated with deeper cement penetration into the graft. This probably is due to the higher cement pressure generated during stem insertion when there is less space for the cement to escape. Better mechanical interlock with the higher cement penetration possibly explains the reduced subsidence with thin cement mantles. Our study also shows that stem retroversion is associated with stem size only, and is larger for thinner stems. This could be explained by thinner stems providing less resistance to torsional forces.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 58 - 58
1 Mar 2010
Ganapathi M Kuiper* J Griffin S Saweeres E Graham N
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The adequacy of cement mantles around some impaction-grafting systems has been criticised yet good clinical results have been reported. This study investigates this contradiction by asking

Does cement mantle thickness affect cement penetration depth?

Does cement mantle thickness affect early mechanical stability?

Twelve artificial femora were prepared to simulate cavitary defects. Porcine cancellous bone was morselized. The defect was reconstructed by impaction grafting, using a size 0, 1 or 2 tamp. Bone cement was injected, and a size 0, 1 or 2 Exeter stem inserted. By using all nine tamp/prosthesis combinations, 0–4 mm thick cement mantles were produced. Femora were positioned in a testing machine and loaded with 2500 cycles of 2500 N. Prosthesis subsidence and retroversion were measured. Each femur was sliced transversely and the sections digitised. Solid cement mantle thickness and cement penetration depth were measured using image analysis. Correlation analysis was used to find if tamp/stem mismatch (nominal mantle thickness) influenced actual solid mantle thickness and cement penetration. We then analysed if tamp size, stem size, solid mantle thickness or cement penetration determined stem subsidence and retroversion.

Cement mantles were produced with an average thickness of 1.7–2.2 mm, with largest variations proximally (1.5–2.8 mm). Average cement penetration was 0.3–2.0 mm, with largest variations proximally (0.4–3.5 mm). Thicker solid mantles gave less penetration (r=−0.62). Stem subsidence ranged from 0.4–2.5 mm and correlated significantly with tamp size (r=0.59, p< .05). Better correlations were found with solid mantle thickness (r=0.90, p< 0.05) and cement penetration depth (r=−0.81). Stem retroversion ranged from 0.1–2.0 degrees and correlated with stem size (r=−0.53) but not with tamp size.

Tamp/stem mismatch determined the thickness of the solid cement mantle around impaction-grafted stems, and thinner mantles were associated with deeper cement penetration. Thinner mantles and deeper penetration were associated with reduced stem subsidence. Stem retroversion was associated with stem size only, and larger for thinner stems. Thinner cement mantles will therefore be associated with deeper penetration and reduced stem subsidence upon loading. This association may explain the good long-term results of impaction-grafted Exeter stems, despite deficient solid cement mantles.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 241 - 241
1 May 2009
Birmingham T Bryant D Fowler P Giffin J Griffin S Kirkley A Litchfield R
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Summary Results of this two-group parallel design randomised controlled trial indicated one and two year outcomes following ACL reconstruction were not different in one hundred and fifty patients using either an ACL functional knee brace or neoprene knee sleeve. Introduction: The primary objective of this study was to compare postoperative outcomes in patients using an ACL functional knee brace and patients using a neoprene knee sleeve

One hundred and fifty patients were randomised to receive an ACL functional knee brace (n=76) or a neoprene sleeve (n=74) at their six week postoperative visit following primary ACL reconstruction. Patients were instructed to wear the knee orthosis during participation in all physical activities. Patients were assessed preoperatively, six weeks, six, twelve, eighteen and twenty-four months postoperatively. Outcome measures included disease-specific quality of life (ACL QOL), KT 1000 and single limb forward hop test administered by a blinded research assistant. One and two-year outcomes were compared after adjusting for baseline scores. A priori directional subgroup hypotheses based on time from injury to surgery, pre-operative KT 1000 scores, and one and two-year compliance scores were evaluated using tests for interactions. Analysis was completed on an intention-to-treat basis.

There were no significant between-group differences for any of the outcomes at one and two-year follow-ups. Mean between-group differences at two years were: 2.87% (95% CI: −3.85 – 9.60) for the ACL QOL, 0.07mm (95% CI: −0.80 – 0.93) for KT 1000 side-to-side difference, and 2.64% (95% CI: −4.57 – 9.85) for hop limb symmetry index. There were no significant subgroup findings and adverse events were similar between groups.

Confidence intervals for between-group differences are narrow and exclude clinically important differences. These findings suggest a functional knee brace does not result in superior outcomes over a neoprene sleeve following ACL reconstruction.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 381 - 381
1 Jul 2008
Ganapathi M Kuiper J Griffin S Saweeres E Graham N
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Purpose: To investigate whether cement mantle thickness influence early migration of the stem after impaction grafting

Methods: Twelve artificial femora were prepared to mimic cavitary defects. After compacting morselized bone into the cavities, Exeter stems were cemented in place. By using all combinations of three sizes tamps and stems (0, 1 and 2), we created cement mantles of 0, 1, 2, 3 and 4 mm thickness. Bones with stems were placed in a testing machine and loaded cyclically to 2,500 N while measuring stem migration. Statistical analysis was by regression analysis. Outcomes were stem subsidence and retroversion, predictors were mantle thickness, tamp size and stem size.

Results: Average stem subsidence after 2500 cycles when using size 1 tamp and stem (2 mm mantle) was 0.94 mm. Cement mantle thickness significantly influ-enced stem subsidence (r=0.68, p=0.015). For a 0 mm mantle, subsidence was 0.59 mm and for a 4 mm mantle it was 2.54 mm. Cement mantle thickness also signifi-cantly influenced stem retroversion (r=0.62, p=0.031). Cement mantle thickness was a better predictor than tamp or stem size.

Discussion: Concern exists that inadequate cement mantles may affect stability of impaction-grafted stems. In our study, larger difference between tamps and stems gave substantially more subsidence and rotation, whereas a smaller difference reduced them. Concerns over thin mantles may have been premature.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 43 - 44
1 Mar 2008
MacDonald S Kirkley A Griffin S Ashley J Griffin C
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Patients with moderate to severe osteoarthritis of the knee, on a waiting list for total knearthroplasty, were recruited to a double-blind, randomized clinical trial evaluating neoprene knee braces containing high-power static magnets or sham magnets. Patients wore the brace for a minimum of six hours per day and were evaluated at baseline, two, six, twelve and twenty-four weeks. The subjective outcomes (MACTAR, WOMAC, KOOS, SF-36) and functional outcomes (six minute walk, thirty second stair climb) showed no statistically significant differences between the groups at any of the follow-up time periods.

The purpose of this study was to compare the effectiveness of neoprene knee braces containing high-power static magnets to sham magnets in the management of osteoarthritis of the knee

No statistically significant difference in patient-related quality-of-life and objective functional evaluation was found between groups.

This study provides patients and doctors with evidence as to the efficacy of this type of therapy. It will allow those individuals on fixed incomes to utilize their resources to the best advantage to minimize their symptoms related to osteoarthritis of the knee.

A prospective double-blinded randomized clinical trial was conducted. Ninety-five patients with moderate to severe osteoarthritis of the knee were randomized to receive a Magnet (M) or Sham (S) knee brace. Both groups were equal with regards to age (M = 71.1 yrs, S = 66.8yrs), severity of disease, gender and all baseline measures. No statistically significant difference in patient-related quality-of-life and objective functional evaluation was found between groups at any time interval.

All study patients were recruited from a knee arthroplasty waiting list. At baseline and at two, six, twelve and twenty-four weeks each patient completed a WOMAC, MACTAR, KOOS quality-of-life questionnaire, SF–36 global health measure, and six minute walk and thirty second stair climb after which they were asked to determine their general fatigue, pain and shortness of breath on a 100mm VAS scale. Patients were instructed to wear their brace at least six hours per day and when active (walking, shopping, golfing).


A reliable and valid measurement tool, The Western Ontario Meniscal Evaluation Tool (WOMET) was developed to assess the benefit of conservative and surgical interventions for meniscal pathology. A methodologic protocol designed by Guyatt was used for the development. This measurement tool can be used as the primary outcome tool in clinical trials evaluating the outcome of patients in this population. It can also be used to monitor a patients’ progress in private practice.

The purpose of this study was to develop a measure of quality of life, which is reliable and valid, to assess the benefit of conservative and surgical interventions for meniscal pathology.

Health-related quality-of-life measurement tool development

A modified methodologic protocol designed by Guyatt was used to develop the Western Ontario Meniscal Evaluation Tool (WOMET) a disease-specific quality of life measurement tool for patients with meniscal pathology. The stages were: 1) item generation, 3) item selection, 4) pretesting. Evaluation of the WOMET included testing reliability, responsiveness and validity.

The final instrument, the Western Ontario Meniscal Evaluation Tool has sixteen items representing the domains of physical symptoms (nine items), sports, recreation/work/lifestyle (four items), and emotions (three items). The instrument proved to be valid by demonstrating predicted correlations with previously published knee measurement tools. Reliability at two weeks was high with an intraclass correlation coefficient of 0.833. The new instrument was also more responsive than other knee measurement tools.

Since the patients own perception of changes in their health status is the most important indicator for success of a treatment, this measurement tool can be used as the primary outcome tool in clinical trials evaluating the outcome of patients in this population. It can also be used to monitor a patients’ progress in private practice


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 142 - 143
1 Mar 2008
Griffin S Willits K Sonneveld H
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Purpose: Posterior Ankle Arthroscopy (PAA) is a relatively new operative technique for a specific and under-recognized ankle problem, posterior ankle impingement. Prospective data on the old technique, posterior ankle arthrotomy, have shown an unacceptable high complication rate. Literature review on PAA found reports on surgical techniques and anatomical studies only. The purpose of this study was to perform a retrospective study, with short-term follow-up to determine the quality of life, function and clinical results after posterior ankle arthroscopy.

Methods: Twenty-three patients underwent a PAA between 1998 and 2004 at our centre. Fifteen patients (16 PAA) were available for follow-up. They filled out the LEFS-score, the AOFAS clinical rating systems, the SF-12, 3 satisfaction scales and also underwent an examination of their ankle.

Results: The mean follow-up time was 32 months (6–74 months). The mean age at time of surgery was 25 years (19–43 years). After surgery they spent on average two weeks on crutches needing pain medication for 1 week. The mean return to work was 1 month (0–3 months) and return to sport was 5 months (1–24 months). 94% of the patients returned to their preoperative level of sport. Complications included five patients with temporary numbness around their scar and one patient with temporary ankle stiffness. There were no permanent neurovascular injuries. The mean LEFS score at follow-up was 75 (65–80; best = 80). The mean AOFAS score was 91 (77–100: 100 = best). The mean SF-12 score was 51.80 PCS (30.77–60.53); 55,80 MCS (44.26–63.33). All reported they had improved after their surgery and would have the surgery again.

Conclusions: Functional and clinical evaluations after a PAA revealed that all of the patients were very satisfied with the result and showed excellent quality of life. Posterior ankle impingement is an under-recognised clinical entity which now has an effective treatment available. Increased clinical focus on this condition may reveal a higher incidence associated with other diagnosis. We are currently evaluating patients pre and postoperative in a prospective study


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 46 - 46
1 Mar 2005
Hart W Griffin S Warren R Jones RS
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Background. Just under 2% of the joint infection work performed over the last 10 years in our institution has involved organisms found in the oropharynx. The issue of antibiotic prophylaxis for dental work in the presence of a joint prosthesis is controversial. However, advanced dental sepsis requires detection and treatment prior to joint replacement.

Methods. Patients from whom non B-haemolytic streptococcal were recovered from revisions of prosthetic joints over the period 1993–2003 were retrospectively reviewed for predisposing factors.

Results. 9 patients had viridans streptococcal infection detected and confirmed by histology and culture at excision arthroplasty. There were 5 total hip joints, 3 knee arthroplasties and 1 shoulder affected. No patient had a history of endocarditis. Two of the patients had previously had multiple revisions. Mean interval in these patients since last surgery was 7.6 years. All patients underwent 2 stage revision procedures. All patients required multiple dental extractions in the interval between 1st and 2nd stage surgery.

On reviewing the patients’ histories further: One patient had reported a broken tooth reported at the time of surgery and been given reassurancethat it was safe to proceed. One patient had an overt dental abscess ongoing for 15 years and one patient had an occult dental abscess revealed on radiology. Two other patients had extensive dental caries with blackened stumps as teeth. Follow-up after antibiotic treatment and revision arthroplasty is limited in these cases but results appear satisfactory at up to five years.

Conclusion. Poor dental care is associated with an increased risk of arthroplasty infection. Looking in the mouth should be a routine part of pre-op assessment prior to primary joint replacement, just as it would be in a cardiac surgery unit. Patients referred from other centres for revision arthroplasty should receive a dental examination if excision arthroplasty cultures yield viridans streptococci.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 72 - 72
1 Jan 2004
Griffin S Steele N
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Successful treatment of the infected arthroplasty remains a major concern to the revision surgeon. We aim to present our audit of the use of the Biomet Femoral Spacer in staged revision of the infected total hip arthroplasty.

Following removal and thorough debridement of the infected joint the spacer is created using the Biomet mould and the surgeon’s choice of cement with additional antibiotics.

Custom moulding allows for the incorporation of intramedullary devices to stabilize periprosthetic fractures.

The patient is then able to mobilize non weight bearing on the spacer until infectious parameters return to normal, before the second stage is attempted.

In our series fifty cases have been identified. Two dislocations, two prosthesis fractures and three repeat second stages are noted. Examples will be presented.

We believe the Biomet Femoral Spacer has a definite role in the management of this difficult problem.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 208 - 208
1 Nov 2002
Griffin S Williams R
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We aim to present an 18 Month Review of one Surgeons Practice Involving 16 Patients with 3 or 4 part Fractures or 3 part Fracture-Dislocations of the Proximal Humerus in patients under 60 years of age.

Management principles include anatomic reduction, internal fixation and early movement.

The implants used in this series include:

The PLANTAN PLATE from ATLANTECH

The STRATEC 4.5 mm ANGLE BLADE PLATE

The POLARUS NAIL and various small cannulated screw systems.

3 patients were treared with minimal fixation, 5 with the AO Bladeplate, 4 with the PLANTAN plate and 4 with the Polarus nail.

Surgical Treatment, Radiographic and Clinical Outcomes will be reviewed. Anatomic considerations, surgical technique and outcomes will be discussed.