Young patients are at increased risk of revision after primary THA (THA). The bearing surface may be of importance for the longevity of the joint. We aimed to compare the risk of revision of primary stemmed cementless THA with MoM and CoC with metal-on-highly-crosslinked-polyethylene (MoXLP) bearings in patients between 20–54 years. From NARA, we included 2,153 MoM, 4,120 CoC and 10,329 MoXLP THA operated between 1995 and 2017. Kaplan-Meier estimator was used for calculation of THA survivorship and Cox regression to estimate the hazard ratio (HR) of revision (95% CI) due to any and specific causes. MoXLP was reference. The median follow-up was 10.3 years for MoM, 6.6 years for CoC and 4.8 years for MoXLP. 15 years postoperatively the Kaplan-Meier survival estimates were 80% (78–83%) for MoM, 92% (91–93%) for CoC and 94% (93–95%) for MoXLP. The 0–2, 2–7 and 7–15 years adjusted HRs of revision by any cause were 1.4 (0.9–2.4), 3.2 (2.1–5.1) and 3.9 (1.9–7.9) for MoM and 1.1 (0.8–1.4), 1.0 (0.7–1.3) and 2.5 (1.3–4.8) for CoC bearings. After 7–15 years follow-up, the unadjusted HR of revision due to aseptic loosening was 5.4 (1.2–24) for MoM and 4.2 (0.9–20) for CoC THA. MoM and CoC had a 7–15 year adjusted HR of revision due to ‘other’ causes of 4.8 (1.6–14) and 2.1 (0.8–5.8). MoXLP bearings were associated with better survival than MoM and CoC bearings, mainly because of lower risk of revision due to aseptic loosening and ‘other’ causes.
Periprosthetic osteolysis resulting in aseptic loosening is a leading cause for total hip arthroplasty (THA) failure. Individuals vary in their susceptibility to osteolysis, and it is thought that heritable factors contribute to this variation. We conducted two genome-wide association studies to identify genetic risk loci associated with osteolysis and genetic risk loci associated with time to prosthesis failure due to osteolysis. The Norway cohort comprised 2,624 subjects after THA recruited from the Norwegian Arthroplasty Registry, 779 with revision surgery for osteolysis. The UK cohort comprised 890 subjects recruited from hospitals in the north of England, 317 with radiographic evidence or revision surgery for osteolysis. All subjects had received a fully cemented or hybrid THA using small-diameter metal or ceramic-on-conventional polyethylene bearing. Osteolysis susceptibility case-control analyses and quantitative trait analyses for time to prosthesis failure were undertaken after genome-wide genotyping. Finally, a meta-analysis of the discovery datasets was undertaken.Introduction
Patients/Materials & Methods
Total hip replacement (THR) in children and very young teenagers is experimental since we do not know long-term results in these. We investigated the clinical and radiographic outcomes of THR performed in children and teenage patients identified in the Norwegian Arthroplasty Register We included 111 patients (132 hips) who underwent THR before 20 years of age., together with information on the primary diagnosis, types of implants, and any revisions that required implant change. Radiographs and Harris hip score (HHS) were evaluated for patients that attended clinical follow-up. The mean age at primary THR was 17 (11–19) years, 60% were girls. Mean follow-up time was 14 (3–26) years. The 10-year survival rate after primary THR (with endpoint any revision) was 70%. Survival was better for the patients operated after 1996 (10 y 50% vs 90%). 39 patients had at least 1 revision and 16 patients had 2 or more revisions. In the latest radiographs, osteolysis and atrophy were observed in 19% and 27% of the acetabulae and 21% and 62% of the femurs, respectively. The mean HHS at the final follow-up was 83 (15–100). EQ-5DVAS was 74 (82 in normal population). The clinical scores after THR in these young patients were acceptable, but many revisions had been performed. The bone stock in many patients was poor, which could complicate future revisions.
There is an ongoing discussion on what bearing surfaces to use in different age groups of total hip replacement patients. We report results from uncemented total hip arthroplasty using ceramic on ceramic bearings reported to the Norwegian Arthroplasty Register in the period 1997–2014. Kaplan Meier and Cox regression analysis adjusting for age, gender and diagnosis was used to assess prosthesis survival at 10 and 15 years after primary operation and to report relative risk of revision. Endpoint was any revision. Comparison with the cemented Charnley prosthesis (n=17180), with metal-on-polyethylene articulations from the same time period was done. Results in age groups <55, 55–64, 65–74, >=75 were investigated. The following femur/cup combinations were used; Filler/Igloo (n=2590), Corail/Pinnacle (n=783), Corail/Duraloc (n=467), SCP Unique/Trilogy (n=363), Polar/R3 (n=253), ABGII/ABGII (n=131), other combinations (n=339). Alumina bearing was used in 3807 hips and Alumina-Zirconium composite bearings in 1119 hips. The overall ten and fifteen years unadjusted Kaplan Meier survivals were 94.8 % and 92.0 % respectively with no statistically significant difference between the brands. The cemented Charnley hip arthroplasty had 93.6 % survival at 15 years, and was not statistically significant different from the uncemented ceramic/ceramic group. The 10 years survival in the age groups <55, 55–64, 65–74, >=75 for the uncemented ceramic/ceramic group was 93.7%, 95.3%, 96.0% and 95.4% respectively with no difference between the uncemented brands and the cemented Charnley prosthesis. We found less revisions in patients >=75 in the Charnley group. In the ceramic on ceramic group 11 head fractures and 3 liner fractures were reported. The 15 years result of uncemented hip replacement with ceramic on ceramic bearing was good, and not different from the Charnley cemented arthroplasty in the age groups <75 years.
