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Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_10 | Pages 71 - 71
1 Oct 2022
MANAGEMENT OF HIP AND KNEE PROSTHESIS JOINT INFECTION (PJI) DUE TO S. AUREUS BY THE “DEBRIDEMENT ANTIBIOTICS AND IMPLANT RETENTION” (DAIR) PROCEDURE IN FRENCH REFERENCE CENTRES (CRIOACS) IN 2019: A RETROSPECTIVE COHORT STUDY
Ferry T Arvieux C Stendel E Nich C Delobel P Zeller V Sotto A Dauchy F RONDE-OUSTAU C Tizon A
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Aim

To describe the management of PJI due to S. aureus in CRIOAcs in 2019 and to particularly focus on the evaluation of the efficacy of DAIR regarding control of infection and risk factors for failure up to 12 months.

Method

Thirteen CRIOAcs were selected to participate to the study. Data concerning the management of all the PJI in the year 2019 were retrospectively collected and registered in eCRFs. Inclusion criteria were: ≥ 18 years old patients with S. aureus ± other bacteria (in per surgical procedure sample); knee or hip PJI and with clinical signs of infection. Patients treated with bacteriophages were excluded. All eligible patients were notified by an information letter. Patients treated by the DAIR procedure were selected, and rate of control of infection (no inflammatory local signs or no new surgical procedure or no S. aureus in case of puncture) was analyzed using Kaplan Meier method and risk factors for failure at 12 months were assessed using Cox regression model.

Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_15 | Pages 78 - 78
1 Dec 2021
IN PATIENTS WITH BONE AND JOINT INFECTION, SIX AND 12 WEEKS OF ANTIMICROBIAL THERAPY SEEM TO HAVE A SIMILAR IMPACT ON THE GUT MICROBIOTA AND NO PARTICULAR ANTIBIOTIC SEEMS TO IMPACT ITS RECOVERY
Benech N LEVAST B Gasc C Cecile B Senneville E Lustig S Boutoille D Dauchy F Zeller V Cazanave C Josse J Laurent F Ferry T
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Aim

Bone and joint infections (BJI) need frequently prolonged antibiotic treatment at high dosage for a total of 6 or 12 weeks depending the type of infection. Impact of such prolonged antibiotic exposure on the gut microbiota has never been assessed.

Method

We performed a national multicentric prospective study of patients with BJI to monitor the gut microbiota dynamic all along antimicrobial treatment. Clinical data and stool collection were performed at the baseline visit (B) within 24h before starting antibiotics, at the end of the treatment (EOT) and 2 weeks after antibiotic withdrawal during a follow-up visit (FU). Microbiota composition was determined by shotgun metagenomic sequencing. Biological markers of gut permeability and inflammation were monitored at each time point.