Current treatment options for displaced acetabular fractures in elderly patients include non-surgical management, surgical fixation and surgical fixation with simultaneous hip replacement, the so-called “fix-and-replace”™. There remains a paucity of evidence to guide surgeons in decision making for these difficult injuries. The aim of this study was to assess the feasibility of performing an appropriately powered RCT between treatment options for acetabular fractures in older patients.

This was an NIHR funded feasibility triple-arm RCT with participation from 7 NHS MTCs. Patients older than 60 were recruited if they had an acetabular fracture deemed sufficiently displaced for the treating surgeon to consider surgical fixation. Randomisation was performed on a 1:1:1 basis. The three treatment arms were non-surgical management, surgical fixation and fix-and-replace. Feasibility was assessed by willingness of patients to participate and clinicians to recruit, drop out rate, estimates of standard deviation to inform the sample size calculation for the full trial and completion rates to inform design of a future definitive trial. EQ-5D was the primary outcome measure at 6 months, OHS and Disability Rating Index were secondary outcome measures.

Of 117 eligible patients, 60 were randomised whilst 50 declined study participation. Nine patients did not receive their allocated intervention. Analysis was performed on an intention to treat basis. During the study period 4 patients withdrew before final review, 4 patients died and 1 was lost to follow-up. The estimated sample size for a full scale study was calculated to be 1474 participants for an EQ-5D MCID of 0.06 with a power of 0.8.

This feasibility study suggests a full scale trial would require international collaboration. This study also has provided observed safety data regarding mortality and morbidity for the fix-and-replace procedure to aid surgeons in the decision-making process when considering treatment options.

Aims

To assess the feasibility of a randomized controlled trial (RCT) that compares three treatments for acetabular fractures in older patients: surgical fixation, surgical fixation and hip arthroplasty (fix-and-replace), and non-surgical treatment.

Displaced acetabular fractures in the older patient present significant treatment challenges. There is evidence the morbidity and mortality associated is similar to the fractured neck of femur cohort. Despite growing literature, there remains significant controversy regarding treatment algorithms; varying between conservative management, to fracture fixation and finally surgical fixation and simultaneous THA to allow immediate full weight bearing.

£250k NIHR, Research for Patient Benefit (Ref: PB-PG-0815-20054). Trial ethical approval (17/EE/0271). After national consultation, 3 arms included; conservative management, fracture fixation and simultaneous fracture fixation with THA. Statistical analysis required minimum 12 patients/3 arms to show feasibility, with an optimum 20/arm. Inclusion criteria; patients >60 years & displaced acetabular fracture. Exclusion criteria: open fracture, THA in situ, pre-injury immobility, polytrauma. Primary outcome measure - ability recruit & EQ-5D-5L at 6 months. Secondary outcome measures (9 months); OHS, Disability Rating Index, radiographs, perioperative physiological variables including surgery duration, blood loss, complications and health economics.

11 UK level 1 major trauma centres enrolled into the trial, commenced December 2017. Failure surgical equipoise was identified as an issue regarding recruitment. Full trial recruitment (60 patients) achieved; 333 patients screened. 66% male, median age 76 (range 63–93), median BMI 25 (range 18–37), 87% full mental capacity, 77% admitted from own home. 75% fall from standing height. 60% fractures; anterior column posterior hemi-transverse. Trial feasibility confirmed December 2020. Presented data- secondary outcomes that are statistically significant in improvement from baseline for only the fix and replace arm, with acceptable trial complications. Issues are highlighted with conservative management in this patient cohort.

Our unique RCT informs design and sample size calculation for a future RCT. It represents the first opportunity to understand the intricacies of these treatment modalities. This RCT provides clinicians with information on how best to provide management for this medically complex patient cohort.

Background

Hip resurfacing has resurged in the last decade due to a renewed interest in metal on metal bearing. One of the proposed advantages is ease of revision of the femoral component. Short term functional results after femoral revision are similar to those after conventional total hip replacement. Survival and function after revision of the acetabular component only or of both components have not been reported. We aimed to assess hip function and implant survival after revision of the acetabular component for failed Birmingham hip resurfacing (BHR).

Background

The mechanical disadvantage and detrimental effect to articular cartilage following meniscectomy has been well documented in the literature. Meniscal repair in the avascular (white on white zone) is controversial and would be deemed inappropriate by many.

Hypothesis

Avascular meniscal tears can be repaired with good clinical outcomes.

Radiofrequency thermal shrinkage of anterior cruciate ligament (ACL) laxity or partial injury is a relatively recent treatment. Studies have shown varied results with this technique but have had small study numbers and mixtures of both primary and reconstructed ACLs. We present our series of 109 patients.

Between 1999 and 2008 our department performed radiofrequency thermal tightening on 109 patients with partial native ACL injury or ACL laxity. Fifty three patients completed both pre and post-operative evaluations at a mean follow-up of 20.5 months. Evaluation consisted of visual analogue pain scores, Tegner activity and Lysholm scoring.

From the 110 patients that underwent thermal shrinkage for ACL instability 21 (19%) went on to require full ACL reconstruction. The decision to convert to full ACL reconstruction was made at a mean of 13 months (sd=12) following thermal shrinkage surgery. Comparing those who required ACL reconstruction with those who did not, we found those requiring reconstruction to be significantly younger. Mean = 25yrs vs. 31.5yrs. (p≤ 0.002)

Fifty three patients completed both pre and post-operative evaluations at a mean follow-up of 20.5 months. Following treatment there was a significant improvement in mean Lysholm scores from 64.4 to 79.5 (p< 8.42x10-7) and pain scores 3.7 to 2.0 (p< 3.06x10-6); however there was a reduction in patients’ activity levels as assessed by Tegner score, from 6.65 to 6.0 (p< 0.019).

Comparing those who required ACL reconstruction with those who did not, we found those requiring reconstruction to be have higher pre-operative level of activity (mean Tegner score = 7.3 vs. 6.5. (p< 0.047)).

Radiofrequency thermal shrinkage of anterior cruciate ligament significantly improves knee function but may not be appropriate for younger patients or patients with high activity levels.

The St Leger total knee replacement is a bicondylar prosthesis developed as a cheaper alternative to other similar implants of its time. Between October 1993 and June 1999, 144 St Leger total knee replacements were implanted in 114 patients. The aim of this study was to clinically and radiologically assess these patients after a mean follow up of 10.22 years.

Between February and July 2007 ninety-one patients recalled for clinical evaluation (using functional and objective Knee Society Scores) and radiological assessment (using the Knee Society Scoring System). 11 patients had died and 12 were lost to follow up or were medically unfit to attend evaluation. Of the ninety-one patients recalled, 18 had had their prostheses revised (19 knees). 63% of prostheses had survived 10 years or more.

Of the patients with St Leger knees in situ (99 knees) the American Knee Scores showed 78% poor, 10% fair, 6% good and 6% excellent results. Radiological assessment identified 12 arthroplasties that had failed (5 femoral components, 5 tibial components and 4 patellae,) 58 that needed close follow up (18 femoral components, 31 tibial components and 38 patellae) and 29 that were well fixed. A best-case Kaplan-Meier cumulative survivorship was 87% at 10 years. (Worst-case was 71% at 10 years)

These 10 year results showed that the St Leger total knee prosthesis did not perform as well as other bicondylar prostheses of the same generation and had a higher revision rate. Despite favourable published mid-term results, the long-term results for the St Leger total knee replacement have shown it to be unreliable and not worth the initial financial saving.

Conversion of failed femoral components of total hip resurfacing to conventional hip replacement is reportedly a straightforward procedure. There is little published to qualify this and what is available suffers from small study numbers and various combinations pre and post-operative implants.

Between 1997 and 2002, the Oswestry Outcome Centre prospectively collected data on 5000 Birmingham Hip Resurfacings (BHRs) performed by 141 surgeons, at 87 hospitals. To date 4526 have survived, 135 died and 165 are lost to follow-up. 174 have been revised, of which 60 were failures of the femoral component. We reviewed modes of failure and post-revision clinical outcomes in this sub-group.

Isolated femoral component failure accounted for 60 hips (1.2%). 28 femoral neck fractures, 14 femoral head collapses, 13 femoral component loosenings, 3 avascular necroses (AVN), 1 femoral loosening followed by fracture and 1 dislocation. Mean time to revision surgery was 2.6 years (1.8 years for neck fracture; 3.4 years femoral loosening, head collapse and AVN). All acetabular components were left in situ. At revision surgery 25 cemented, 25 uncemented and 10 unknown femoral prostheses were used with 56 BHR modular heads, 2 custom-made Exeter heads and 2 Thrust Plate heads. 47 patients completed outcome scores post-revision surgery. Median modified Harris Hip Score was 82 (IQ range=63–93) and Merle d’Aubigne score was 14 (IQ= 9.5–15) at a mean follow up of 3.9 years post-revision. The 4526 surviving resurfacings had a median hip score of 96 (IQ=87–100) p≤4.558x10-8 and median Merle score of 17 (IQ=14–18) p≤1.827x10-7. Mean 7.0 years follow up. There was no difference in outcomes between cemented and un-cemented revision components nor were there differences between fractured neck of femur and femoral loosening, head collapse or AVN.

Following revision of the femoral component to a conventional hip replacement, function is significantly worse than surviving resurfacings.

Introduction: Conversion of failed femoral components of total hip resurfacing to conventional hip replacement is reportedly a straightforward procedure. There is little published to qualify this and what is available suffers from small study numbers and various combinations pre and post-operative implants.

Method: Between 1997 and 2002, the Oswestry Outcome Centre prospectively collected data on 5000 Birmingham Hip Resurfacings (BHRs) performed by 141 surgeons, at 87 hospitals. To date 4526 have survived, 135 died and 165 are lost to follow-up.

174 have been revised, of which 60 were failures of the femoral component.

We reviewed modes of failure and post-revision clinical outcomes in this sub-group.

Results: Isolated femoral component failure accounted for 60 hips (1.2%). 28 femoral neck fractures, 14 femoral head collapses, 13 femoral component loosenings, 3 avascular necroses (AVN), 1 femoral loosening followed by fracture and 1 dislocation. Mean time to revision surgery was 2.6years (1.8years for neck fracture; 3.4years femoral loosening, head collapse and AVN).

All acetabular components were left in situ. At revision surgery 25 cemented, 25 uncemented and 10 unknown femoral prostheses were used with 56 BHR modular heads, 2 custom-made Exeter heads and 2 Thrust Plate heads.

47 patients completed outcome scores post-revision surgery. Median modified Harris Hip Score was 82 (IQ range=63–93) and Merle d’Aubigne score was 14 (IQ= 9.5–15) at a mean follow up of 3.9years post-revision.

The 4526 surviving resurfacings had a median hip score of 96 (IQ=87–100) p≥4.558x10-8 and median Merle score of 17 (IQ=14–18) p≥1.827x10-7. Mean 7.0 years follow up.

There was no difference in outcomes between cemented and uncemented revision components nor were there differences between fractured neck of femur and femoral loosening, head collapse or AVN.

Discussion: Following revision of the femoral component to a conventional hip replacement, function is significantly worse than surviving resurfacings.

Endoprosthetic replacement is often the preferred treatment for neoplastic lesions as internal fixation has been shown to have a high failure rate. Due to anatomical location, disease factors and patient factors internal fixation may be the treatment of choice. No reports exist in the literature regarding the use of locking plates in the management of neoplastic long bone lesions.

Data was collected prospectively on the first 10 patients who underwent locking plate fixation of neoplastic long bone lesions. Data was collected on the nature of the lesion, surgery performed, complications and outcome.

The patients mean age was 56.6 (15–88). Six lesions were metastatic, one haematological (myeloma) and 3 were primary bone lesions (lymphoma, Giant cell tumour, simple bone cyst). In nine cases a fracture through the lesion had occurred. Anatomical locations of the lesions were; proximal humerus (four), proximal tibia (three), distal femur (two) and distal tibia (one). Cement augmentation of significant bone defects was necessary in seven cases.

The mean hospital stay was 8 days (3–20). There were no inpatient complications. Five patients received adjuvant radiotherapy and one patient received neo-adjuvant radiotherapy to the lesion. There have been 3 deaths. All were due to metastatic disease and occurred between 6 and 12 months after surgery. The mean follow up in the surviving patients is currently 9 months (5–16). There have been no fixation related complications. Patients who had suffered a fracture had restoration of their WHO performance status. At last follow up the mean MSTS was 78% (57–90) for lower limb surgery and 70% (63–76) for upper limb surgery. These figures compare favourably with the results of endoprosthetic replacement.

The early results of locking plate fixation for neoplastic long bone lesions are excellent. Follow up continues to observe how these devices perform in the long term.

Literature searches are commonly performed by medical professionals when carrying out research and during study of a particular topic. Traditionally this was performed manually in a library using a system called index medicus, developed in the early years of the 20th century, and was an arduous task. Over recent years, this has commonly been performed online using electronic search engines, which has drastically reduced the difficulty and time involved in performing a thorough literature search.

Electronic versions of index medicus began in 1964 and were termed MEDLARS. Medline was developed soon after and for many years available on CD-ROM within libraries. In 1997, PUBMED became free to all online, incorporating Medline. (1) Use of online electronic search engines has increased enormously over recent years. In 1996 7 million searches were performed per annum, increasing to 400 million searches per annum in 2001. (1)

The researcher has the ability online to identify articles dating back to 1966, some 39 years of published research and articles to digest.

We performed a retrospective study of 100 medical professionals in a busy district general hospital in the UK with the purpose of identifying how retrospective many of the searches were.

Results showed only 29% of subjects researched papers more than 15 years old, with 65% of subjects only looking at papers 10 years old or younger.

Our study shows that many researchers are now ignoring articles beyond a certain age, and as a result much important research is being largely ignored and possibly repeated.

Introduction: With the introduction of out-patient waiting time targets, there has been increasing pressure on clinics to accommodate both new referrals and follow-up patients. Departments have found it increasingly difficult to continue long-term follow-up of patients post arthroplasty.

We have piloted a new system of purely therapist led clinics and assessed this with an anonymous patient survey.

Method: Since 2005 and following a training program for the therapists involved, 110 arthroplasty patients have passed through the new clinics. They are seen at 6 weeks, 6 and 12 months and then 3, 5 and 10 years. Their ROM, stability and XRAY findings are documented and each patient completes Oxford Knee, SF 12 and WOMAC scores. If there are problems at any stage they are seen in the surgeon led clinic.

Results: 69% of patients responded to the survey and in general they were very satisfied with the new system. 75% felt that been seen by the therapist alone still fully addressed their needs with 79% having an overall impression of either excellent or very good. The patients rated the therapists professionalism, assessment and information delivery as good to excellent in over 80%.

Conclusion: We feel that with the introduction of this new system, we will be able to continue long-term follow-up of all our patients post arthroplasty. With their regular assessments and scoring we will be able to monitor the success of their replacements and theoretically identify early any problems.