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Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_15 | Pages 49 - 49
1 Dec 2021
PLASMA-CELL INFILTRATION ON HISTOPATHOLOGICAL SAMPLES OF CHRONIC BONE AND JOINT INFECTIONS DUE TO CUTIBACTERIUM ACNES: A SERIES OF 25 CASES
Trecourt A Brevet M Champagnac A Conrad A Josse J Dupieux-Chabert C Valour F Ferry T
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Aim

The aim of this study was to confirm that Mirra's criterion (≥ 5 Polymorphonuclears (PMNs) per field in 5 high power fields (HPFs)) is not adequate for diagnosis of chronic bone and joint infections (BJIs) due to Cutibacterium acnes (C. acnes). The second objective was to determine if plasma-cell infiltration, that is a classical marker of chronic inflammation, could be useful for the diagnosis of chronic BJIs due to C. acnes.

Methods

We retrospectively selected 25 patients from 2009 to 2013 with chronic BJIs due to C. acnes. In addition of Mirra's criterion, the number of plasma-cells (≥5 plasma-cells/5 HPFs, defined as “CRIOAc Lyon's criterion”) was implemented in the histopathological analysis. Patients were defined as infected, if at least one of the two criteria were present.