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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 25 - 25
1 Mar 2012
CLINICAL, MECHANICAL AND HISTOPATHOLOGICAL EVALUATION OF A BIOENGINEERED LONG-TERM BIORESORBABLE SILK FIBROIN GRAFT IN A ONE YEAR GOAT STUDY FOR DEVELOPMENT OF A FUNCTIONAL AUTOLOGOUS ANTERIOR CRUCIATE LIGAMENT
Altman G Horan R Weitzel P Horan D Mortarino E DeAngelis N Toponarski I Huang J Boepple H Prudom J Richmond J
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Objectives

We hypothesise that a long-term bioresorbable hydrophilic silkworm silk device, the SeriACL(tm) scaffold, can support the development and remodelling of native functional ligament tissue if designed to anticipate the remodelling curve of an ACL graft. This study evaluated the SeriACL scaffold for ACL replacement in a goat model at 3, 6 and 12 months.

Methods

The ACL of 43 goats was replaced in an arthroscopically assisted procedure. The ACL was excised, a guide pin driven into the femur and 6mm diameter antegrade drilling performed. The tibial tunnel was drilled under direct visualisation. The graft was anchored around a post on the femur, tensioned to 50N and cycled 30x before tibial fixation with a staple and sutures around a post. Animals were clinically, mechanically and histologically evaluated.