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Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_17 | Pages 69 - 69
1 Dec 2018
VANCOMYCIN CONCENTRATIONS IN THE CERVICAL SPINE AFTER INTRAVENOUS ADMINISTRATION: RESULTS FROM AN EXPERIMENTAL PIG STUDY
Bue M Hanberg P Tøttrup M Thomassen M Sorensen HB Thillemann TM Andersson TL Søballe K
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Aims

Vancomycin may be an important drug for intravenous perioperative antimicrobial prophylaxis in spine surgery. We assessed single-dose vancomycin intervertebral disc, vertebral cancellous bone, and subcutaneous adipose tissue concentrations using microdialysis in a pig model.

Methods

8 female pigs received 1,000 mg of vancomycin intravenously as a single dose over 100 minutes. Microdialysis probes were placed in the C3-C4 intervertebral disc, C3 vertebral cancellous bone, and subcutaneous adipose tissue, and vancomycin concentrations were obtained over 8 hours. Venous blood samples were obtained as reference.

Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_22 | Pages 74 - 74
1 Dec 2017
BONE AND SUBCUTANEOUS TISSUE PHARMACOKINETICS OF VANCOMYCIN IN TOTAL KNEE ARTHROPLASTY PATIENTS
Bue M Tøttrup M Hanberg P Langhoff O Sorensen HB Thillemann TM Andersson TL Søballe K
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Aim

The incidence of orthopaedic methicillin-resistant staphylococcus aureus infections is increasing. Vancomycin may therefore play an increasingly important role in orthopaedic perioperative antimicrobial prophylaxis. Adequate antimicrobial concentrations at target site is essential for prevention of orthopaedic infections. Current studies investigating perioperative bone and soft tissue concentrations of vancomycin are sparse and challenged by a lack of appropriate methods. The aim of this study was therefore to assess the concentration of vancomycin in plasma, subcutaneous tissue and bone after single dose administration using microdialysis (MD) in patients undergoing total knee replacement.

Method

1,000 mg of vancomycin was postoperatively administered intravenously over 100 minutes to 10 male patients undergoing primary total knee replacement. Vancomycin concentrations in plasma, subcutaneous tissue (SCT), cancellous and cortical bone were measured the following 8 hours. MD was applied for sampling in solid tissues. The vancomycin concentration in MD-samples was determined using ultra-high performance liquid chromatography, whilst the free plasma concentration was determined using a chemistry analyzer*.