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The Bone & Joint Journal
Vol. 106-B, Issue 5 Supple B | Pages 32 - 39
1 May 2024
Briem T Stephan A Stadelmann VA Fischer MA Pfirrmann CWA Rüdiger HA Leunig M

Aims

The purpose of this study was to evaluate the mid-term outcomes of autologous matrix-induced chondrogenesis (AMIC) for the treatment of larger cartilage lesions and deformity correction in hips suffering from symptomatic femoroacetabular impingement (FAI).

Methods

This single-centre study focused on a cohort of 24 patients with cam- or pincer-type FAI, full-thickness femoral or acetabular chondral lesions, or osteochondral lesions ≥ 2 cm2, who underwent surgical hip dislocation for FAI correction in combination with AMIC between March 2009 and February 2016. Baseline data were retrospectively obtained from patient files. Mid-term outcomes were prospectively collected at a follow-up in 2020: cartilage repair tissue quality was evaluated by MRI using the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. Patient-reported outcome measures (PROMs) included the Oxford Hip Score (OHS) and Core Outcome Measure Index (COMI). Clinical examination included range of motion, impingement tests, and pain.


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_12 | Pages 29 - 29
23 Jun 2023
Briem T Stadelmann VA Rüdiger HA Leunig M
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Femoroacetabular impingement is a prearthritic deformity frequently associated with early chondral damage. Several techniques exist for restoring larger cartilage defects. While AMIC proved to be an effective treatment in knee and ankle, there are only short-term data available in hip. This study aimed to investigate the mid-term clinical outcome of patients with chondral lesions treated by AMIC and evaluate the quality of repair tissue via MRI.

This retrospective, single center study includes 18 patients undergoing surgical hip dislocation for FAI between 2013 and 2016. Inclusion criteria were: cam or pincer-type FAI, femoral or acetabular chondral lesions > 1 cm2, (IRCS III-IV). Due to exclusion criteria and loss-to-follow-up 9 patients (10 hips) could be included. Patient reported outcome measures included Oxford Hip Score (OHS) & Core Outcome Measure Index (COMI)). MRIs were evaluated using the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score.

None of the patients underwent revision surgery except screw removals from the greater trochanter. Followup data indicate a satisfactory to good hip function at 5 years: PROMS improved from pre- to postop at 5 years: OHS from 38.1 to 43.4, COMI from to 1.8 and UCLA from 4 to 8.1 respectively. MOCART score was 67.5 postoperatively. Subgrouping showed slightly better results for acetabular defects (Ø 69.4) compared femoral defects (Ø 60).

Based on the reported mid-term results, we consider AMIC as a valuable treatment option for larger chondral defects of the hip.


Bone & Joint Open
Vol. 3, Issue 9 | Pages 666 - 673
1 Sep 2022
Blümel S Leunig M Manner H Tannast M Stetzelberger VM Ganz R

Aims

Avascular femoral head necrosis in the context of gymnastics is a rare but serious complication, appearing similar to Perthes’ disease but occurring later during adolescence. Based on 3D CT animations, we propose repetitive impact between the main supplying vessels on the posterolateral femoral neck and the posterior acetabular wall in hyperextension and external rotation as a possible cause of direct vascular damage, and subsequent femoral head necrosis in three adolescent female gymnasts we are reporting on.

Methods

Outcome of hip-preserving head reduction osteotomy combined with periacetabular osteotomy was good in one and moderate in the other up to three years after surgery; based on the pronounced hip destruction, the third received initially a total hip arthroplasty.


The Bone & Joint Journal
Vol. 104-B, Issue 7 | Pages 826 - 832
1 Jul 2022
Stadelmann VA Rüdiger HA Nauer S Leunig M

Aims

It is not known whether preservation of the capsule of the hip positively affects patient-reported outcome measures (PROMs) in total hip arthroplasty using the direct anterior approach (DAA-THA). A recent randomized controlled trial found no clinically significant difference at one year postoperatively. This study aimed to determine whether preservation of the anterolateral capsule and anatomical closure improve the outcome and revision rate, when compared with resection of the anterolateral capsule, at two years postoperatively.

Methods

Two consecutive groups of patients whose operations were performed by the senior author were compared. The anterolateral capsule was resected in the first group of 430 patients between January 2012 and December 2014, and preserved and anatomically closed in the second group of 450 patients between July 2015 and December 2017. There were no other technical changes between the two groups. Patient characteristics, the Charlson Comorbidity Index (CCI), and surgical data were collected from our database. PROM questionnaires, consisting of the Oxford Hip Score (OHS) and Core Outcome Measures Index (COMI-Hip), were collected two years postoperatively. Data were analyzed with generalized multiple regression analysis.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_14 | Pages 46 - 46
1 Nov 2021
Stadelmann V Rüdiger H Nauer S Leunig M
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Until today it is unknown whether preservation of the joint capsule positively affects patient reported outcome (PROs) in DAA-THA. A recent RCT found no clinical difference at 1 year. Since 2015 we preserve the capsule suture it at the end. We here evaluate whether this change had any effect on PROs and revisions, 2 years post-operatively.

Two subsequent cohorts operated by the senior author were compared. The capsule was resected in the first cohort (January 2012 – December 2014) and preserved in the second cohort (July 2015 – December 2017). No other technical changes have been introduced between the two cohorts. Patient demographics, Charlson Comorbidity Index (CCI), and surgical data were collected from our clinical information system. 2-years PROs questionnaires (OHS, COMI Hip) were obtained. Data was analyzed with generalized multiple regression analysis.

430 and 450 patients were included in the resected and preserved cohorts, respectively. Demographics, CCI surgical time and length of stay were equal in both groups. Blood loss was less in the preserved cohort (p<.05). Four patients had a revision (1 vs 3, n.s.). Once corrected for demographics, capsule preservation had significant worse PROs: +0.24 COMI (p<.001) and −1.6 OHS points (p<.05), however, effects were much smaller than the minimal clinically important difference (0.95 and 5 respectively). The date of surgery (i.e. surgeon's age) was not a significant factor.

In this large retrospective study, we observed statistically significant, but probably clinically not relevant, worse PROs with capsule preservation. It might be speculated that the not resected hypertrophied capsule could have caused this difference.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_14 | Pages 47 - 47
1 Nov 2021
Blümel S Leunig M Manner H Tannast M Stetzelberger V Ganz R
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Femoral head necrosis in the context of high impact gymnastics of young adolescents is rare but seems a more serious complication compared to a Perthes like necrosis.

Between 2017 and 2019, three young females aged from12 to 14 years were referred due incapacitating hip pain and severe collapsing femoral head necrosis. The indication of hip preserving surgery was based on the extent of the necrosis, presence of a vital lateral pillar and joint subluxation.

In one of our 3 cases total head involvement made THR necessary, which was performed elsewhere. In the remaining 2 cases, head reduction osteotomy plus periacetabular osteotomy led to a good and a fair result.

Repetitive impact between the main supplying vessels on the posterolateral femoral neck and the posterior acetabular wall in hyperextension/ external rotation could be the cause of severe femoral head necrosis in three adolescent female gymnasts we are reporting on. Supra-selective angiography or sonography may be helpful to improve indication. Targeted adaptation of training methods should be discussed. Due to the severe vascular insult, results have to be considered moderate.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_11 | Pages 44 - 44
1 Aug 2018
Levingson C Naal F Salzmann G Zenobi-Wong M Leunig M
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To characterize the quality of flap tissues and the resident cells in order to provide a scientific rationale for reattaching flap tissues during surgery.

11 acetabular chondral flaps and 3 non-delaminated cartilage samples were resected during open hip surgeries and the anatomical orientation was marked. The viability was measured in 7 flaps with Live Dead staining and the distribution of the extracellular matrix components was investigated in 7 oriented flaps by histology. The chondrogenic potential of the residing cells (P2) was investigated via pellets assays (5 flaps). Their capacity to outgrow from flap particles was tested upon encapsulation in 4mm-diameter fibrin glue discs (6 flaps).

The viability in flaps was 49.4 ± 6.5 % compared to 70.6 ± 8.2 % in non-delaminated cartilage, (not significant). Histology showed a progression of fibrillation from the delaminated side towards the site of attachment. This degraded state correlated with the capacity of the cells to outgrow, with 60.6 ± 33 % of the gel area covered by migrating cells after 4 weeks in culture. However, the cells in flaps showed a decreased chondrogenic potential than chondrocytes from non-delaminated cartilage.

Our findings indicate that flaps contain viable cells that can outgrow from the tissue due to the degraded state of the matrix. The poor chondrogenic property of the cells suggests they are unlikely to produce enough matrix to provide a solid attachment of the delaminated tissue upon migration.


The Bone & Joint Journal
Vol. 100-B, Issue 7 | Pages 853 - 861
1 Jul 2018
Leunig M Hutmacher JE Ricciardi BF Impellizzeri FM Rüdiger HA Naal FD

Aims

The classical longitudinal incision used for the direct anterior approach (DAA) to the hip does not follow the tension lines of the skin and can lead to impaired wound healing and poor cosmesis. The purpose of this retrospective study was to determine the satisfaction with the scar, and functional and radiographic outcomes comparing the classic longitudinal incision with a modified skin crease ‘bikini’ when the DAA is used for total hip arthroplasty (THA).

Patients and Methods

A total of 964 patients (51% female; 59% longitudinal, 41% ‘bikini’) completed a follow-up questionnaire between two and four years postoperatively, including the Oxford Hip Score (OHS), the University of North Carolina ‘4P’ scar scale (UNC4P) and two items for assessing the aesthetic appearance of the scar and symptoms of numbness. The positioning of the components, rates of heterotopic ossification (HO) and rates of revision were assessed.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_1 | Pages 81 - 81
1 Jan 2018
Fürnstahl P Lanfranco S Leunig M Ganz R
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Severe femoral head deformities due to Perthes' disease are characterized by limitation of ROM, pain, and early degeneration, eventually becoming intolerable already in early adulthood. Morphological adaptation of the acetabulum is substantial and complex intra- and extraarticular impingement sometimes combined with instability are the underlying pathologies.

Improvement is difficult to achieve with classic femoral and acetabular osteotomies. Since 15 years we have executed a head size reduction. With an experience of more than 50 cases no AVN of the femoral head was recorded. In two hips fracture of the medial column of the neck has been successfully treated with subsequent screw fixation. The clinical mid-term results are characterized by substantial increase of hip motion and pain reduction.

Surgical goal is to obtain a smaller head, well contained in the acetabulum. It should become as spherical as possible and the gliding surface should be covered with best available cartilage. Together, it has to be accomplished under careful consideration of the blood supply to the femoral head. In the majority of cases acetabular reorientation is necessary to optimize joint stability.

Femoral head segment resections without guidance is difficult. Therefore, 3D-simulation for cut direction and segment size including the implementation of the resultant osteotomy configuration was developed using individually manufactured cutting jigs. First experience in five such cases have revealed good results. The forthcoming steps are the improvement of computer algorithm and automation. Goal is that with first cut decision the other cuts are automatically determined resulting in optimal head size and sphericity.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_1 | Pages 40 - 40
1 Jan 2018
Leunig M Hutmacher J Ricciardi B Rüdiger H Impellizzeri F Naal F
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The classical longitudinal incision used for the direct anterior approach (DAA) does not follow the relaxation tension lines of the skin and can lead to impaired wound healing and poor scar cosmesis. The purpose of this study was to determine patient functional and radiographic outcomes of a modified skin crease “bikini” incision used for the DAA in THR.

964 patients (51% female; 59% longitudinal, 41% bikini) completed 2 to 4 years after surgery a follow-up questionnaire including the Oxford Hip Score (OHS), the University of North Carolina 4P scar scale (UNC4P), and two items for assessing aesthetic appearance and symptoms of numbness. Implant position, rates of radiographic heterotopic ossification and required revision were assessed.

UNC4P total (p<0.001) and OHS (p=0.013) scores were better in the bikini compared the longitudinal group. The proportion of aesthetically very satisfied patients was higher (p<0.001) in the bikini group. The proportion of patients reporting numbness in the scar was higher (p<0.001) in the longitudinal (14.5% versus 7.5%, respectively). Radiographic cup abduction angles, stem position and ectopic ossification rates did not differ between the groups. No differences in the revision rates of both groups being 2.1% in the longitudinal and 1.5% in the Bikini group. Although differences were not huge, Bikini incision resulted in better patient-related outcomes and satisfaction related to the scar. Our study showed that a short oblique “bikini” skin crease incision for the DAA can be performed safely without compromising implant positioning or increasing symptoms suggesting lateral femoral cutaneous nerve dysesthesia. As it is less extensile it should be used after having gained significant experience with the classic longitudinal incision.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_4 | Pages 1 - 1
1 Feb 2017
Guggi T Leunig M Rienmüller A
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Dedication to quality has a longstanding tradition within the Schulthess Clinic. Pioneering documentation Maurice E. Müller initiated an International Documentation & Evaluation System (IDES) in the era of hip replacement becoming an increasingly wide spread and standardized procedure. Starting in 1984, IDES was used to document each and every hip replacement and as of 1995 also for every knee arthroplasty performed. Norbert Gschwend became the driving authority in the clinic for standardizing documentation and regular long term follow-up intervals for all patients.

With increasing interest in patient reported outcomes (PROMs) a shift took place in the basic conception and electronic means (iPads) were introduced in 2012 to let patients complete their part of questionnaires, i.e. EQ-5D, OHS, OKS, UCLA & WOMAC while the clinical part was addressed in the same manner using HHS & KSS.

Optimizing user experience while answering routine questions and allowing for the physician to quickly enter required data without the numbing experience of ever same paper forms largely increased the return on information. This approach also guarantees for complete data sets, often a problem when using pen and paper.

Using these modern tools in combination with a refined recall procedure, we today show follow-up rates of well over 90% in the first post-operative years vs rates of 80% or less prior to introduction.

As of late 2012 the Swiss implant registry for knees & hips was introduced and here again we today use iPads with an app specifically designed to quickly document and register all operations on a daily base, reducing the chore of using paper or web based on line options from 3 to 10 minutes per operation to a mere 20 seconds, fully plausibilized and in this way never returned for corrections.

Pooling this data allows not only for generalized and stringent quality control but also facilitates spotting aberrant trends in the sense of an early warning system within our clinic with regard to procedures and implants.

Pioneering this approach to facilitate & perfect all documentation related procedures we aspire towards an elevated quality level in reporting to help sustain & guarantee patient satisfaction despite the high day-by-day volume.


The Bone & Joint Journal
Vol. 99-B, Issue 1 | Pages 16 - 21
1 Jan 2017
Aprato A Leunig M Massé A Slongo T Ganz R

Aims

Several studies have reported the safety and efficacy of subcapital re-alignment for patients with slipped capital femoral epiphysis (SCFE) using surgical dislocation of the hip and an extended retinacular flap. Instability of the hip and dislocation as a consequence of this surgery has only recently gained attention. We discuss this problem with some illustrative cases.

Materials and Methods

We explored the literature on the possible pathophysiological causes and surgical steps associated with the risk of post-operative instability and articular damage. In addition, we describe supplementary steps that could be used to avoid these problems.


The Bone & Joint Journal
Vol. 96-B, Issue 1 | Pages 5 - 18
1 Jan 2014
Leunig M Ganz R

The use of joint-preserving surgery of the hip has been largely abandoned since the introduction of total hip replacement. However, with the modification of such techniques as pelvic osteotomy, and the introduction of intracapsular procedures such as surgical hip dislocation and arthroscopy, previously unexpected options for the surgical treatment of sequelae of childhood conditions, including developmental dysplasia of the hip, slipped upper femoral epiphysis and Perthes’ disease, have become available. Moreover, femoroacetabular impingement has been identified as a significant aetiological factor in the development of osteoarthritis in many hips previously considered to suffer from primary osteoarthritis.

As mechanical causes of degenerative joint disease are now recognised earlier in the disease process, these techniques may be used to decelerate or even prevent progression to osteoarthritis. We review the recent development of these concepts and the associated surgical techniques.

Cite this article: Bone Joint J 2014;96-B:5–18.


Bone & Joint Research
Vol. 1, Issue 10 | Pages 245 - 257
1 Oct 2012
Tibor LM Leunig M

Femoroacetabular impingement (FAI) causes pain and chondrolabral damage via mechanical overload during movement of the hip. It is caused by many different types of pathoanatomy, including the cam ‘bump’, decreased head–neck offset, acetabular retroversion, global acetabular overcoverage, prominent anterior–inferior iliac spine, slipped capital femoral epiphysis, and the sequelae of childhood Perthes’ disease.

Both evolutionary and developmental factors may cause FAI. Prevalence studies show that anatomic variations that cause FAI are common in the asymptomatic population. Young athletes may be predisposed to FAI because of the stress on the physis during development. Other factors, including the soft tissues, may also influence symptoms and chondrolabral damage.

FAI and the resultant chondrolabral pathology are often treated arthroscopically. Although the results are favourable, morphologies can be complex, patient expectations are high and the surgery is challenging. The long-term outcomes of hip arthroscopy are still forthcoming and it is unknown if treatment of FAI will prevent arthrosis.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 127 - 127
1 Sep 2012
Corten K Etsuo C Leunig M Ganz R
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Introduction

Ectopic ossification (EO) at the acetabular rim has been suggested to be associated with pincer impingement and to lead to ossification of the labrum. However, this has never been substantiated with histological, radiographic and MRI findings in large cohorts of patients. We hypothesized that it is more a bone apposition of the acetabular rim and that it occurs more frequently in coxa profunda (CP) hips.

Materials and Methods

In the first part, a cohort of 20 hips with this suspected ectopic rim ossification (EO) pattern were identified. The radiographic features that could be associated with this ossification pattern were described and evaluated by a histologic examination of intra-operative samples taken from the rim trimming. In the second part, we assessed the prevalence of this ectopic ossification process in a cohort of 203 patients treated for FAI.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 185 - 185
1 Sep 2012
Von Knoch F Neuerburg C Impellizzeri F Goldhahn J Frey P Naal F Von Knoch M Leunig M
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Background

Second-generation high-carbon CoCrMo-alloy metal-on-metal total hip arthroplasty (THA) was introduced in the late 1980s following reports of early loosening, impingement, pronounced wear, and hypersensitivity in the first-generation metal-on-metal articulations. There has been inconsistent data that specifically addresses the clinical performance and longevity of second-generation metal-on-metal THA. The purpose of this study was to evaluate the survival of second-generation metal-on-metal primary THA and to assess the influence of demographic factors on implant survival in a large patient cohort.

Methods

One thousand two hundred and seventy second-generation 28 mm metal-on-metal primary THA in 1121 patients were performed at one institution from 1994 to 2004. According to the International Documentation and Evaluation System patients were followed routinely at one year, two years and every five years thereafter. Clinical and radiographic outcome data was prospectively recorded using a hospital joint registry. At a mean follow-up of 6.8 years postoperatively, the probability of survival of THA was estimated using the method of Kaplan and Meier. Relative risk factors for implant failure that included age, gender, BMI, type of implant fixation and size of implant components were calculated using the Cox proportional-hazards model.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 2 | Pages 179 - 184
1 Feb 2012
Sutter M Hersche O Leunig M Guggi T Dvorak J Eggspuehler A

Peripheral nerve injury is an uncommon but serious complication of hip surgery that can adversely affect the outcome. Several studies have described the use of electromyography and intra-operative sensory evoked potentials for early warning of nerve injury. We assessed the results of multimodal intra-operative monitoring during complex hip surgery. We retrospectively analysed data collected between 2001 and 2010 from 69 patients who underwent complex hip surgery by a single surgeon using multimodal intra-operative monitoring from a total pool of 7894 patients who underwent hip surgery during this period. In 24 (35%) procedures the surgeon was alerted to a possible lesion to the sciatic and/or femoral nerve. Alerts were observed most frequently during peri-acetabular osteotomy. The surgeon adapted his approach based on interpretation of the neurophysiological changes. From 69 monitored surgical procedures, there was only one true positive case of post-operative nerve injury. There were no false positives or false negatives, and the remaining 68 cases were all true negative. The sensitivity for predicting post-operative nerve injury was 100% and the specificity 100%. We conclude that it is possible and appropriate to use this method during complex hip surgery and it is effective for alerting the surgeon to the possibility of nerve injury.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 173 - 173
1 May 2011
Naal F Pilz R Guggi T Munzinger U Hersche O Leunig M
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Concerns recently arose regarding hip resurfacing arthroplasty (HRA), mainly referring to the metal-on-metal articulation that results in increased metal ion concentrations and that may be associated with weird soft tissue reactions. Although a number of short-term reports highlighted excellent and encouraging outcomes after HRA, mid- to long-term follow-up studies are sparse in the current literature. This study aimed to determine the five-year results of HRA using the Durom® prosthesis in the first consecutive 50 cases. We prospectively assessed clinical and radiographic data for all patients undergoing HRA with this implant. Follow-ups were scheduled at six weeks, one year, two years and five years after surgery. All complications, revisions and failures were noted. Harris Hip Scores (HHS) and the range of motion (ROM) were determined preoperatively and at each follow-up. Oxford Hip Scores (OHS) and University of California at Los Angeles (UCLA) activity levels were determined at the last control. Comparisons were performed using paired t-tests after testing for normal distribution. The cohort comprised 13 women and 36 men (50 hips) with a mean age of 53.3 ± 10.7 years and a mean BMI of 25.9 ± 3.7 kg/m2. After a mean follow-up of 60.5 ± 2.3 months five hips had to be revised, corresponding to a resvision rate of 10%. There occurred two femoral neck fractures (after two and eleven months) and one aseptic loosening of the femoral component (after 68 months). One implant was exchanged to a conventional stem-type design due to persistent hip pain (after eight months), and one hip underwent a femoral offset correction due to a symptomatic impingement between the neck and the cup (after 29 months). There occurred no intra- or other postoperative complications. Clinically, ROM significantly improved after surgery. Hip flexion increased from 91.1 ± 15.8° to 98.9 ± 6.5° (p=0.0007), internal rotation from 5.5 ± 6.9° to 11.1 ± 8.1° (p=0.0005), external rotation from 19.2 ± 12.5° to 28.8 ± 9.1° (p=0.0001), and abduction from 27.3 ± 10.5° to 40.2 ± 11.0° (p< 0.0001). The HHS significantly increased from 55.9 ± 12.3 points to 96.5 ± 8.5 points. The OHS averaged 14.3 ± 3.0 points, and UCLA activity levels averaged 7.7 ± 1.7. The present results demonstrate that despite satisfactory clinical outcomes in terms of patient scores and ROM, the high revision rate of 10% after a mid-term follow-up is disappointing.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 526 - 527
1 Oct 2010
Naal F Impellizzeri F Leunig M Mannion A Munzinger U Sieverding M
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During the last decade, outcome assessment in orthopaedic surgery has increasingly focused on patient self-report questionnaires. The Oxford Hip and Knee Scores (OHS and OKS) were developed for the self-assessment of pain and function in patients undergoing joint replacement surgery. These scores proved to be reliable, valid, and responsive to clinical change, however, no German version of these useful measures exists. We therefore cross-culturally adapted the OHS and OKS according to the recommended forward/backward translation protocol and assessed the following metric properties of the questionnaires in 105 (OHS) and 100 (OKS) consecutive patients undergoing total hip or knee replacement in our clinic: feasibility (percentage of fully completed questionnaires), reliability (intraclass correlation coefficients (ICC) and Bland and Altman’s limits of agreement), construct validity (correlation with the Western Ontario and McMaster Universities Index (WOMAC), Harris Hip Score (HHS), Knee Society Score (KSS), Activities of Daily Living Scale (ADLS), and Short Form (SF-)12), floor and ceiling effects, and internal consistency (Cronbach’s alpha, CA). We received 96.6% (OHS) and 91.9% (OKS) fully completed questionnaires. Reliability of both questionnaires was excellent (ICC > 0.90). Bland and Altman’s limits of agreement revealed no significant bias. Correlation coefficients with the other questionnaires ranged from −0.30 (SF-12 Mental Component Scale) to 0.82 (WOMAC) for the OHS, and from −0.22 (SF-12 Mental Component Scale) to −0.77 (ADLS) for the OKS. For both questionnaires, we observed no floor or ceiling effects. The internal consistency was good with a CA of 0.87 for the OHS and 0.83 for the OKS. In conclusion, the German versions of the OHS and OKS are reliable and valid questionnaires for the self-assessment of pain and function in German-speaking patients with hip or knee osteoarthritis. Considering the present results and the brevity of the measures, we recommend their use in the clinical routine.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 526 - 526
1 Oct 2010
Naal F Impellizzeri F Leunig M Mannion A
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The goal of this study was to develop and validate a short, evaluative self-report questionnaire for the clinical self-assessment of patients with hip osteoarthritis (OA). If used together with other self-report outcome tools (e.g. generic or physical activity measures), such a short joint-specific questionnaire could avoid an increased burden to the patients and decrease the risk of data loss. All items of the new score (Schulthess Hip Score, SHS) were generated solely on patient perceptions, for item removal we used the clinical severity-importance rating and inter-item correlation methods. The final score consisted of only five items. We then assessed the following metric properties of the SHS in 105 consecutive patients with symptomatic hip OA (mean age, 63.4 ± 11 years, 48 women) undergoing total hip arthroplasty (THA) in our clinic: proportion of evaluable questionnaires, reproducibility, internal consistency, concurrent validity, and responsiveness. 97% of the questionnaires were evaluable. Reproducibility of the SHS was excellent (intraclass correlation coefficient (ICC) 0.90; standard error of the measure (SEM) 6.4). Exploratory factor analysis indicated that all items loaded on only 1 factor which accounted for 69.4% of the total variance. Cronbach’s alpha was 0.88. Evidence of convergent validity was provided by moderate to high correlations with scores and subscales of the WOMAC (r = 0.58–0.78), Oxford Hip Score (r = 0.78), Harris Hip Score (r = 0.37), SF-12 physical component scale (r = 0.57), UCLA activity scale (r = 0.48), and Tegner score (r = 0.53). Evidence of divergent validity was provided by a lower correlation with the SF-12 mental component scale (r = 0.37). The SHS proved to be responsive with an effect size (ES) of 2.15 and a standard response mean (SRM) of 1.74 six months after THA. Taken together, the results of this study provide evidence to support the use of the five-item self-report SHS in patients with hip osteoarthritis. Considering the brevity of this score, it could be easily used together with other measures such as generic and physical activity assessment tools, without overburdening patients with an inordinate number of items and questions.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 386 - 386
1 Jul 2010
Madan S Leunig M Ganz R
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Introduction: Patients who develop proximal femoral growth arrest present a typical deformity of short femoral neck, high riding greater trochanter, and caput valgum. This is seen usually seen in Perthes, AVN due to treatment of CDH, and sometimes in epiphyseal dysplasia.

Method: We present a series of 34 cases (34 hips) treated at the above institutes. The cases treated in Berne were prior to 2002. Twenty patients were females. There were 24 patients with Perthes, nine with old healed and treated DDH, and one with epipyhseal dysplasia. All had Trendelenburg or delayed Trendelenburg sign. They had an average shortening of 3.5 cms, and their age range was 14 yrs to 64 yrs. Pre-op assessement was done with plain radiographs, CT scan, and or MRI scan.

Results: Their Merle D’Aubigne score improved from 13 (10 to 15) to 17 (15 to 18) at the latest follow up. Twenty four (70%) had good to excellent result. Five have since undergone a total hip replacement, and five have some pain but can do reasonable amount of activity. The follow-up is 6 years (2 to 13 years). There was one trochanteric non-union, but no cases of AVN.

Discussion: We describe the technique of biomechanically improving the moment arm and muscle length with this procedure. This helps the soft tissues to strengthen, improve force vectors in the correct direct in the hip, perhaps improve the longevity of the joint and also prepare the hip soft tissues for future THR.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 306 - 306
1 May 2010
Naal F Schmied M Maffiuletti N Leunig M Hersche O
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There is only a paucity of information on the outcome of resurfacing arthroplasty in patients suffering from hip osteoarthritis secondary to developmental dysplasia (DDH). When performing arthroplasty in dysplastic hips, the anatomic abnormalities offer reconstructive challenges, in particular in resurfacing. The present study was therefore conducted to address the following questions: Can hip resurfacing arthroplasty provide satisfactory clinical results in patients with DDH? Can the patients return to sports and recreational activities? Can the hip biomechanics be restored? And finally, can surface arthroplasty reestablish a normal, symmetric gait pattern? The study comprised 24 consecutive patients (32 hips) with a mean age of 44.2 years who underwent surface replacement due to hip osteoarthritis secondary to DDH. Surgery was performed by two senior surgeons using either the Durom implant or the Birmingham Hip Resurfacing prosthesis, dependent on the surgeon’s preference. At a mean follow-up of 43 months, all patients were evaluated cross-sectionally. We assessed clinical and radiographical data and investigated spatiotemporal gait parameters using an electronic mat. The Harris Hip Score improved from 54.7 +/−13.3 to 97.3 +/−5.2 (p< 0.001) and University of California at Los Angeles (UCLA) activity levels increased from 5.3 +/−2.0 to 8.6 +/−1.6 (p< 0.001), respectively. Hip flexion improved from 95.7° +/−16.5° to 106.7° +/−10.6° (p< 0.001). At a mean of 11.2 +/−4.8 weeks after surgery, all patients returned to sports activity. They participated in a mean of 6.0 +/−2.6 different disciplines, 2.8 +/−1.3 times and 4.1 +/−3.6 hours per week. The most common disciplines were cycling, swimming, exercise walking and downhill-skiing. Spatiotemporal parameters of gait demonstrated a symmetrical gait pattern without major differences to normative data. Both, the hip lever arm ratio and the femoral offset increased significantly (p< 0.001) from 0.48 +/−0.07 to 0.57 +/−0.08 and from 39.3 +/−8.2 mm to 45.6 +/−6.2 mm, respectively. Grade I heterotopic ossifications were seen in two hips, there were no Grade II or III ossifications. Two surface replacements failed, both failures could be attributed to surgical errors. The surface arthroplasty risk index was 3.2 +/−1.4 for the entire cohort and 4.5 for the revision cases. Femoral radiolucencies were detected in ten of the remaining 30 hips. The present study demonstrated that hip resurfacing achieved satisfactory clinical results in patients with hip osteoarthritis secondary to DDH. The failure rate of 6.3% did not reach our expectations, however, both failures could be attributed to surgical errors. Further follow-up is nevertheless of utmost importance to assess the significance of femoral stem radiolucencies in this young and active group of patients.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 63 - 63
1 Mar 2009
Krueger A Kohl S Leunig M Siebenrock K Beck M
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Purpose: The purpose of this study was to examine the arthroscopy findings in the hips of patient with persistent pain after surgical hip dislocation for femoroacetabular impingement syndrome.

Type of study: Retrospective, consecutive series of patients

Patients and Methods: Sixteen consecutive patients (6 male/10 female; average age 33,5 years 19–60y) with persistent pain after surgical hip dislocation for the treatment of femoroacetabular impingement were included. At the index surgery, all patients had an osteo-chondroplasty of the head neck junction and a resection of the acetabular rim with reattachment of the labrum in 9 cases. All patients had a preoperative arthro-MRI and were treated with arthroscopy of the hip.

Results: At arthroscopy all reattached labra were stable. In the cases without preservation of the labrum, the joint capsule was attached level with the acetabular rim and had important synovitis. All patients had adhesions between the neck of the femur and joint capsule or between labrum and capsule. In 3 patients the arthroscopic procedure was technically limited by massive thickening of the capsule. Overall 75% (12 of 16) patients showed less pain or were pain free. MDA improved from preoperatively 13 to 16 points at last follow up.

Conclusions: Persistent pain after surgical dislocation of the hip could result from intraarticular adhesions that can be shown in the MRI. Hip arthroscopy after previous surgery can be demanding due to scarring. If the adhesions can be released good results can be achieved. Hip arthroscopy is a save therapeutical tool to treat patients with intraarticulary adhesions after surgical dislocation of the hip for femoroacetabular impingement.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 64 - 64
1 Mar 2009
Leunig M Mladenov K Jamali A Meyer D Martinez A Beck M Ganz R
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Background: Acetabular retroversion has been proposed to contribute to the development of osteoarthritis of the hip. For the diagnosis of this condition, conventional AP pelvic radiographs may represent a reliable, easily available diagnostic modality as they can be obtained with a reproducible technique allowing the anterior and posterior acetabular rims to be visible for assessment. This study was designed to

establish a method to directly quantify anatomic acetabular version on AP pelvic radiographs and to

determine the validity of the radiographic “cross-over-sign” to detect acetabular retroversion.

Methods: Using 43 desiccated pelves (86 acetabuli) the anatomic acetabular versions were measured at three different transverse planes (cranially, centrally and caudally). From these pelves, standardized AP pelvic radiographs were obtained. To directly measure central acetabular version (AV), a modified radiographic method is introduced for the use of AP pelvic radiographs. Moreover, the validity of the radiographic “cross-over-sign” to detect cranial acetabular retroversion was determined.

Results: The mean central and caudal anatomic AV were approximately 20°, the mean cranial AV was 8°. Cranial retroversion (AV < 0°) was present in 19 of 86 hips (22%). A linear correlation was found between the central and cranial AV. Below 10° of central AV, all acetabuli were cranially retroverted. Between 10° and 20°, 30% of the acetabuli were cranially retroverted and above 20°, only one of 45 acetabuli was cranially retroverted. The radiographic measurement of the central AV (20.3° ± 6.5) correlated strongly with the anatomic AV (20.1° ± 6.4). The sensitivity of the ‘cross-over-sign’ to detect an cranial acetabular anteversion of less than 4° was 96%, its specificity 95%, and the positive predictive and negative predictive values 90% and 98%, respectively.

Conclusions: The cranial AV is on average 12° lower than the central AV, with the latter directly measurable from AP pelvic radiographs. A central AV of less than 10° was associated with cranial retroversion. The presence of a positive ‘cross-over-sign’ is a highly reliable indicator of cranial AV of < 4°.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 63 - 64
1 Mar 2009
Kalberer F Sierra R Madan S Meyer D Ganz R Leunig M
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Background: Femoroacetabular Impingement is now considered a prearthritic hip mechanism. It frequently occurs in patients with subtle anatomic abnormalities of the acetabulum, “acetabular retroversion”, which is often difficult to detect on standart xrays. Early diagnosis is of utmost importance as surgical intervention in early stages can most likely halt progression of disease. The objective of this study was to assess wether an easily visible anatomic landmark on an anteroposterior (AP) pelvic xray can be used to screen patients with acetabular retroversion.

Methods: The AP pelvic xrays of 1010 patients who were seen at the autors’ institution for a painful hip were reviewed over a 16 year period. Those xrays that did not meet standardized criteria were excluded leaving 149 AP radiographs (298 hips) for analysis. The ‘crossover sign’ (COS), indicative of acetabular retroversion, was recorded for each hip. An easily visible landmark, the prominence of ischial spine (PRIS) into the true pelvis was also recorded and measured. Interobserver and intraobserver variability was assessed.

Results: The presence of the PRIS as diagnostic of acetabular retroversion showed a sensitivity of 91% (95%CI 0.85 to 0.95), a specifity of 98% (95% CI 0.94 to 1.00), a positive predictive value of 98% (95%CI 0.94 to 1.00), a negativ predictive value of 92% (95% CI 0.87 to 0.96). There was good and very good intraobserver and interobserver reliability for measurements of the COS and PRIS, respectively.

Conclusion: There was excellent sensitivity and positive predictive value of the PRIS as a radiographic marker of acetabular retroversion. The rims of the anterior and posterior walls are sometimes not clearly visible, and even if they are, their translation into a reliable interpretation of acetabular retroversion is difficult. The PRIS sign appears as a good visible prominence on the AP radiographs which can’t be easily confused.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 9 - 10
1 Mar 2006
Puloski S Leunig M Ganz R
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Background: Numerous radiographic indices have been described to help define the degree of acetabular deficiency in adult patients with developmental dysplasia. The lateral centre-edge angle (LCE) of Wiberg and the anterior centre-edge (ACE) angle of Lequesne are two of the commonly measured indices that are reported in the evaluation of procedures that are used to correct acetabular deformity. Unfortunately much of the reported literature that tries to define abnormal indices has been extrapolated from the evaluation of “normal” pelvi or those with osteoarthritis. The purpose of this study was to evaluate the application and limitations of the LCE and ACE angles in a group of patients with developmental dysplasia treated with periacetabular osteotomy.

Methods: 50 cases were randomly selected from a larger cohort of over 500 patients with acetabular dysplasia treated at our institution with periacetabular osteotomy. The preoperative and post osteotomy false profile and anteroposterior plain radiographs were reviewed. Cases were first grouped into one of three categories based on a general estimation of the location of acetabular deficiency as determined from the AP radiograph.

A number of radiographic indices were measured and compared including the VCE angle, LCE angle, and acetabular angles of Tönnis and Sharp. Variation in both the VCE and LCE angle was evaluated by measuring the index using two different reference points. This included (1) the traditional mark of the furthest point along the sclerotic density of the weight bearing zone and (2) an alternate point representing the furthest extent of lateral or anterior bony coverage. Additional sources of measurement error were determined. The relationships between the centre-edge angles and other radiographic indices were determined. An evaluation of the indices and correction on post osteotomy radiographs was also performed.

Results: Fifty cases in 45 patients were reviewed. There were 31 female and 19 males. The mean age was 30 years (range, 17–45). A general review of all preoperative AP radiographs revealed that all hips displayed some degree of lateral deficiency.

Nineteen of these cases displayed a “classic” lateral and anterior deficiency. However, 19 cases displayed a more uniform deficiency and 12 cases were in fact retroverted.

Evaluation of the radiographic indices revealed:

A mean VCE angle of 2.3 degrees (SD±12.7) and LCE angle of 3.4 degrees (SD±9.3). These were corrected to 25.8 degrees (SD±11.6) and 28.6 degrees (SD±8.7) following osteotomy.

The VCE and LCE angles did not appear to be correlated (r=0.35). This is contrary to previous studies evaluating non-dysplastic pelvi (Chosa et al., 1997). The LCE angle showed no significant correlation to other lateral coverage indices (Tönnis, Sharp).

No correlation was seen either in the post osteotomy values, or in the absolute degree of correction.

The alternate VCE (aVCE), using the most anterior aspect of the acetabular margin as the reference point was consistently larger (p< 0.001) with a mean difference of 27.1 degrees (SD±10.0). There was however a positive correlation between these two methods of measurements (r=0.77).

A similar variation was seen when comparing the LCE angle and the alternate LCE (aLCE). The mean difference between measurements was 7.3 degrees (SD±8.7)(p< 0.001).

The mean VCE in hips with primarily anterior and lateral deficiency (−6.7°±12.5) was significantly lower (p< 0.01) than those with uniform deficiency (5.1°±8.3) or those with retroverted acetabuli (8.9°±13.3)

Dysplastic hips with a decreased LCE angle but relatively normal Tönnis angle should be treated carefully as osteotomy may result in excessive angular correction in the coronal plane, thus creating a negative Tönnis angle. This can ultimately lead to problems with lateral and/or anterolateral impingement.

Potential sources of error in measurement that were identified include:

Deformity of the acetabulum and occasional abnormalities of the femoral head limit the ability to identify the center of the rotation necessary to measure the centre-edge angles. Subluxation of the femoral head also creates a degree of error. These difficulties were observed in over 20% of cases.

Alteration in pelvic tilt and rotation theoretically decreases the accuracy of measurement. Practically over 30% of radiographs were seen as less than ideal.

The absolute reference point for VCE and LCE angles as the end of the sclerotic line in the weight bearing area can be (1) difficult to define (2) does not always represent the most anterior or lateral extent of the acetabular margin. This discrepancy appears to increases in dysplastic hips. This has been suggested previously (Fabeck et al.,1999) and is now supported by our findings.

Conclusion: Centre-edge indices can be useful parameters in defining acetabular morphology. However, these parameters should not be used in isolation and the absolute values do little to define the overall location and degree of deficiency in hips with acetabular dysplasia. A number of significant sources of measurement error limit their accuracy especially in patients with hip dysplasia. Currently, it is our feeling that no single radiographic parameter fully defines the specific morphology in each individual case nor reflects the success of correction when treating patients with periacetabular osteotomy.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 77 - 77
1 Mar 2006
Beck M Leunig M Ganz R
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Femoroacetabular impingement recently was recognized as cause for osteoarthritis of the hip. There are two mechanism of impingement: (1) cam impingement caused by a non-spherical head, and (2) pincer impingement due to acetabular overcover. We hypothesized that both mechanism result in different articular damage patterns. Of 302 analyzed hips only 26 had an isolated cam and 16 an isolated pincer impingement. Cam impingement caused anterosuperior acetabular cartilage damage with a separation between labrum and cartilage. During flexion the cartilage is sheared off the bone by the non-spherical part of the femoral head. In pincer impingement the cartilage damage was located circumferentially, invovolving only a narrow strip along the acetabular rim. During motion the labrum is crushed between the acetabular rim and the femoral neck causing degeneration and ossification of the labrum.

Cam and pincer impingement are two basic mechanism that lead to osteoarthrosis of the hip. The articular damage pattern differs substantially. Isolated cam or pincer impingement is rare, in most hips a combination is present. Labral damage indicates ongoing impingement and rarely occurs alone.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 9 - 9
1 Mar 2006
Leunig M Ganz R
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Lesions of the acetabular rim have been implicated as a cause of hip pain in various pathologic conditions and are considered to predispose the hip to development of accelerated degenerative disease. In developmental dysplasia of the hip (DDH) and anterior femoroacetabular impingement (FAI), intrinsically normal intraarticular soft tissue structures are exposed to joint loading forces that physically exceed their tolerance level posing these pathomorphologies as precursors of osteoarthritis. In DDH, the deficient acetabular coverage of the femoral head has been related to osteoarthrosis, while the orientation of the femoral head is considered to play a less important role. The resulting instability and anterolateral migration tendency of the femoral head leads to chronic shear stresses at the acetabular margin. In FAI, repetitive peak contact pressures occur when the femoral head-neck junction abuts against the acetabular rim during joint flexion. Predisposing morphologies are femoral abnormalities such as an insufficient femoral head-neck offset seen in head tilt or pistol grip deformities, slipped capital femoral epiphysis, or malunited femoral neck fractures with the orientation and shape of the acetabulum contributing to this pathology. In classical DDH and FAI, diagnosis is primarily based on clinical signs and symptoms and conventional radiography. However, in cases of clinical and radiographic borderline disease establishment of the correct diagnosis is sometimes difficult. This presentation reports how the MRarthrographic appearance of acetabular rim pathologies can be used to differentiate both conditions. In DDH and FAI, labral pathologies localize identically with a predilection to the anterosuperior quadrant of the acetabulum. Labral tears are found in 64% in both groups. The volume of the labrum is increased in 86% DDH hips but in none of the FAI hips. Ganglion formation in the periacetabular area is seen in 71% DDH and 21% FAI hips. These findings provide evidence that the anterosuperior acetabular rim represents the initial fatiguing site of the hip under both DDH and FAI. The capability of MR-arthrography to depict differences in labral pathologies suggests this method as a helpful diagnostic tool to define the most appropriate treatment strategy specifically in borderline cases.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 7 | Pages 1012 - 1018
1 Jul 2005
Beck M Kalhor M Leunig M Ganz R

Recently, femoroacetabular impingement has been recognised as a cause of early osteoarthritis. There are two mechanisms of impingement: 1) cam impingement caused by a non-spherical head and 2) pincer impingement caused by excessive acetabular cover. We hypothesised that both mechanisms result in different patterns of articular damage. Of 302 analysed hips only 26 had an isolated cam and 16 an isolated pincer impingement. Cam impingement caused damage to the anterosuperior acetabular cartilage with separation between the labrum and cartilage. During flexion, the cartilage was sheared off the bone by the non-spherical femoral head while the labrum remained untouched. In pincer impingement, the cartilage damage was located circumferentially and included only a narrow strip. During movement the labrum is crushed between the acetabular rim and the femoral neck causing degeneration and ossification.

Both cam and pincer impingement lead to osteoarthritis of the hip. Labral damage indicates ongoing impingement and rarely occurs alone.


The Journal of Bone & Joint Surgery British Volume
Vol. 85-B, Issue 3 | Pages 462 - 462
1 Apr 2003
KLOEN P LEUNIG M GANZ R


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_II | Pages 114 - 114
1 Jul 2002
Leunig M Siebenrock K Ganz R
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Acetabular dysplasia is the most common cause of secondary osteoarthritis of the hip joint resulting in many young adults requiring total hip replacement (THR). Although THR has a predictably good functional result, the longevity of prosthetic replacement in this young cohort of patients has been notably inconsistent. Therefore, there has been an increasing interest in better methods for treating acetabular dysplasia in young adults with the emphasis shifting from the femoral to the acetabular side during the last 10 years.

For reorientation of the acetabular fragment to improve coverage, various pelvic and periacetabular osteotomies have been proposed. Most necessitate more than one incision and change of patient position. The Bernese periacetabular osteotomy (PAO) combines complete and incomplete osteotomies, as well as a controlled fracture requiring only one approach. This is beneficial for the vascular supply of the acetabular fragment and allows an additional anterior capsulotomy without restrictions.

The osteotomies of the PAO are close to the joint and therefore allow a pronounced acetabular reorientation similar to juxta-articular triple osteotomies. Moreover, anteversion and medialization/lateralization of the center of rotation can be corrected with only minimal changes of the pelvic geometry. This enables a normal delivery in young females. The partially remaining posterior column protects the sciatic nerve from iatrogenic damage. The polygonal shape of the osteotomy and avoidance of soft tissue stripping (abductors) are advantageous for the stabilization of the reoriented fragment, thus facilitating early mobilization and rehabilitation.

Seventy-five dysplastic hips with a minimal follow-up of 10 years after PAO were evaluated. There were good to excellent result in 73% of these patients. The mean lateral center edge angle increased from 6° to 34° and the mean anterior center edge angle improved from 4° to 28°. The post-osteotomy index angle was successfully reduced from an average of 26° to 6°. Lateralisation of the femoral head was reduced from an average 16° to 10° compared to 11° on the contralateral side. Femoral head cranialisation also normalized from 9° to 4° compared to 5° on the opposite hip. Poor results were correlated with older patients, pre-existing arthritis, labral pathology, and mal-correction. Treatment of labral lesions was performed only as a supplementary measure if the labrum was unstable and included either refixation or resection.

The PAO is a technically demanding procedure, and is unforgiving of seemingly minor imprecision. With the fact that 85% of our major complications occurred within the first fifty osteotomies, it is obvious that a learning curve exists for this procedure. It is imperative that surgeons undertaking this procedure do so with a full understanding of each stage and have the necessary patience, attention to detail and adequate cadaveric experience with the technique.


The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 1 | Pages 66 - 69
1 Jan 2002
Kloen P Leunig M Ganz R

Osteonecrosis of the femoral head can be caused by a variety of disorders and affects the relatively young patient. Most studies have concentrated on the femoral changes; the sites of early lesions of the labrum and acetabular cartilage have not been recorded. We studied 17 hips with osteonecrosis and a wide congruent joint space on radiographs and by direct inspection of the femoral head, labrum and acetabular cartilage during surgery. All of the femoral heads had some anterosuperior flattening which reduced the head-neck ratio in this area. A consistent pattern of damage to the labrum and the acetabular cartilage was seen in all hips. Intraoperatively, impingement and the cam-effect with its spatial correlation with lesions of the labrum and acetabular cartilage were observed. These findings could be helpful when undertaking conservative surgery for osteonecrosis, since the recognition of early radiologically undetectable acetabular lesions may require modification of the surgical technique.


The Journal of Bone & Joint Surgery British Volume
Vol. 83-B, Issue 2 | Pages 171 - 176
1 Mar 2001
Ito K Minka-II M Leunig M Werlen S Ganz R

We have observed damage to the labrum as a result of repetitive acetabular impingement in non-dysplastic hips, in which the femoral neck appears to abut against the acetabular labrum and a non-spherical femoral head to press against the labrum and adjacent cartilage. In both mechanisms anatomical variations of the proximal femur may be a factor. We have measured the orientation of the femoral neck and the offset of the head at various circumferential positions, using MRI data from volunteers with no osteoarthritic changes on standard radiographs. Compared with the control subjects, paired for gender and age, patients showed a significant reduction in mean femoral anteversion and mean head-neck offset on the anterior aspect of the neck. This was consistent with the site of symptomatic impingement in flexion and internal rotation, and with lesions of the adjacent rim. Furthermore, when stratified for gender and age, and compared with the control group, the mean femoral head-neck offset was significantly reduced in the lateral-to-anterior aspect of the neck for young men, and in the anterolateral-to-anterior aspect of the neck for older women. For patients suspected of having impingement of the rim, anatomical variations in the proximal femur should be considered as a possible cause.


The Journal of Bone & Joint Surgery British Volume
Vol. 81-B, Issue 5 | Pages 915 - 920
1 Sep 1999
Sckell A Leunig M Fraitzl CR Ganz R Ballmer FT

Free patellar tendon grafts used for the intra-articular replacement of ruptured anterior cruciate ligaments (ACL) lack perfusion at the time of implantation. The central core of the graft undergoes a process of ischaemic necrosis which may result in failure. Early reperfusion of the graft may diminish the extent of this process.

We assessed the role of peritendinous connective tissue in the revascularisation of the patellar tendon graft from the day of implantation up to 24 days in a murine model using intravital microscopy. The peritendinous connective-tissue envelope of the graft was either completely removed, partially removed or not stripped before implantation into dorsal skinfold chambers of recipient mice.

Initial revascularisation of the grafts with preserved peritendinous connective tissues began after two days. The process was delayed by five to six times in completely stripped patellar tendons (p < 0.05). Only grafts with preserved connective tissues showed high viability whereas those which were completely stripped appeared to be subvital.

The presence of peritendinous connective tissues accelerates the revascularisation of free patellar tendon grafts.


The Journal of Bone & Joint Surgery British Volume
Vol. 79-B, Issue 2 | Pages 341 - 341
1 Mar 1997
LEUNIG M HERTEL R


The Journal of Bone & Joint Surgery British Volume
Vol. 79-B, Issue 2 | Pages 341 - 341
1 Mar 1997
LEUNIG M HERTEL R


The Journal of Bone & Joint Surgery British Volume
Vol. 79-B, Issue 2 | Pages 230 - 234
1 Mar 1997
Leunig M Werlen S Ungersböck A Ito K Ganz R

Since January 1993 we have carried out MR arthrography on 23 patients with clinical symptoms and signs of abnormality of the acetabular labrum. Most of the patients were young adults. Such symptoms are known precursors of osteoarthritis, and therefore early and accurate evaluation is required.

We assessed the value of MR arthrography of the hip as a minimally-invasive diagnostic technique, in a prospective study and compared the findings with those at subsequent operations. All the patients complained of groin pain; 22 had a positive acetabular impingement test and 15 had radiological evidence of hip dysplasia.

In 21 of the patients, MR arthrography suggested either degeneration or a tear of the labrum or both. These findings were confirmed at operation in 18 patients, but there was no abnormality of the labrum in the other three. In two of the patients, MR arthrography erroneously suggested an intact labrum. Both MR arthrography and intraoperative inspection located lesions of the superior labrum most often, and these appeared slightly larger on arthrography than at operation.

We consider that MR arthrography is a promising diagnostic technique for the evaluation of abnormalities of the acetabular labrum.


The Journal of Bone & Joint Surgery British Volume
Vol. 78-B, Issue 4 | Pages 584 - 587
1 Jul 1996
Leunig M Hertel R

We present three young men who sustained closed diaphyseal fracture of the tibia and later developed severe osteocutaneous necrosis induced by heat during intramedullary reaming. They all had a narrow medullary cavity and in all a tourniquet had been used. Each developed a pretibial cutaneous blister soon after operation. In the following month severe osteomyelitis ensued, requiring segmental resection and osteocutaneous reconstruction.