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Bone & Joint Open
Vol. 4, Issue 11 | Pages 873 - 880
17 Nov 2023
Swaby L Perry DC Walker K Hind D Mills A Jayasuriya R Totton N Desoysa L Chatters R Young B Sherratt F Latimer N Keetharuth A Kenison L Walters S Gardner A Ahuja S Campbell L Greenwood S Cole A

Aims

Scoliosis is a lateral curvature of the spine with associated rotation, often causing distress due to appearance. For some curves, there is good evidence to support the use of a spinal brace, worn for 20 to 24 hours a day to minimize the curve, making it as straight as possible during growth, preventing progression. Compliance can be poor due to appearance and comfort. A night-time brace, worn for eight to 12 hours, can achieve higher levels of curve correction while patients are supine, and could be preferable for patients, but evidence of efficacy is limited. This is the protocol for a randomized controlled trial of ‘full-time bracing’ versus ‘night-time bracing’ in adolescent idiopathic scoliosis (AIS).

Methods

UK paediatric spine clinics will recruit 780 participants aged ten to 15 years-old with AIS, Risser stage 0, 1, or 2, and curve size (Cobb angle) 20° to 40° with apex at or below T7. Patients are randomly allocated 1:1, to either full-time or night-time bracing. A qualitative sub-study will explore communication and experiences of families in terms of bracing and research. Patient and Public Involvement & Engagement informed study design and will assist with aspects of trial delivery and dissemination.


Bone & Joint Open
Vol. 4, Issue 8 | Pages 573 - 579
8 Aug 2023
Beresford-Cleary NJA Silman A Thakar C Gardner A Harding I Cooper C Cook J Rothenfluh DA

Aims

Symptomatic spinal stenosis is a very common problem, and decompression surgery has been shown to be superior to nonoperative treatment in selected patient groups. However, performing an instrumented fusion in addition to decompression may avoid revision and improve outcomes. The aim of the SpInOuT feasibility study was to establish whether a definitive randomized controlled trial (RCT) that accounted for the spectrum of pathology contributing to spinal stenosis, including pelvic incidence-lumbar lordosis (PI-LL) mismatch and mobile spondylolisthesis, could be conducted.

Methods

As part of the SpInOuT-F study, a pilot randomized trial was carried out across five NHS hospitals. Patients were randomized to either spinal decompression alone or spinal decompression plus instrumented fusion. Patient-reported outcome measures were collected at baseline and three months. The intended sample size was 60 patients.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_8 | Pages 6 - 6
1 Aug 2022
Bada E Dwarakanath L Sewell M Mehta J Jones M Spilsbury J McKay G Newton-Ede M Gardner A Marks D
Full Access

Children undergoing posterior spinal fusion (PSF) for neuromuscular and syndromic scoliosis were admitted to the paediatric intensive care (PIC) until about 6 years ago, at which time we created a new unit, a hospital floor-based spinal high-dependency unit-plus (SHDU-plus), in response to frequent bed-shortage cancellations. This study compares postoperative management on PIC with HDU-plus for these non-hospital floor suitable children with syndromic and neuromuscular scoliosis undergoing PSF.

Retrospective review of 100 consecutive children with syndromic and neuromuscular scoliosis undergoing PSF between June 2016 and January 2022. Inclusion criteria were: 1) diagnosis of syndromic or neuromuscular scoliosis, 2) underwent PSF, 3) not suitable for immediate postoperative hospital floor-based care. Exclusion criteria were children with significant cardio-respiratory co-morbidity requiring PIC postoperatively.

55 patients were managed postoperatively on PIC and 45 on SHDU-plus. No significant difference between groups was found with respect to age, weight, ASA grade, preoperative Cobb angles, operative duration, number of levels fused and estimated blood loss. 4 patients in the PIC group and 1 in the SHDU-plus group were readmitted back to PIC or HDU following step-down to the hospital floor. Average length of stay was 2 days on PIC and 1 day on SHDU-plus. Average total length of hospital stay was 16.5 days in the PIC group and 10.5 days in the HDU-plus group. 19 (35%) patients developed complications in the PIC group, compared to 18 (40%) in SHDU-plus. Mean specialist unit charge per day was less on SHDU-plus compared with PIC. There were no bed-shortage cancellations in the SHDU-plus group, compared to 11 in the PIC group.

For children with neuromuscular or syndromic scoliosis undergoing PSF and deemed not suitable for post-operative care on the hospital floor, creation of a SHDU-plus was associated with fewer readmissions back to PIC or HDU, shorter hospital stays, an equivalent complication rate, significant cost-saving and fewer cancellations. Level of Evidence: Therapeutic Level III.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_8 | Pages 3 - 3
1 Aug 2022
Tailor P Sewell M Jones M Spilsbury J Marks D Gardner A Mehta J
Full Access

The lordosis distribution index (LDI) describes distribution of lumbar lordosis, measured as the % of lower lumbar lordosis (L4-S1) compared to global lordosis (L1-S1) with normal value 50–50%. Maldistributed LDI is associated with higher revision in short lumbar fusions, 4 vertebrae1. We hypothesise maldistributed LDI is also associated with mechanical failure in longer fusions.

Retrospective review of 29 consecutive ASD patients, aged 55+, undergoing long lumbar fusion, 4 levels, with >3-years follow-up. LDI, pelvic incidence (PI) and sagittal vertical axis (SVA) were measured on pre- and post-op whole spine standing X-rays (Fig A and B). Patients were categorized according to their pelvic incidence (PI) and postoperative LDI: Normal (LDI 50 80), Hypolordotic (LDI < 50), or Hyperlordotic (LDI > 80) and assessed for failure rate compared to normal LDI and PI <60.

Mean follow-up 4.5 years. 19 patients had mechanical failures including junctional failure and metalware fracture. PI >60o was associated with higher mechanical failure rates (Chi^2 p<0.05). Hypolordotic LDI was associated with 82% mechanical failure (Chi^2 p<0.001), Hyperlordotic 88% mechanical failure (Chi^2 p<0.001) and Normal 8% mechanical failure (Table 1).

Maldistributed LDI, whether Hyperlordotic or Hypolordotic, correlated with 10× greater mechanical failure rate compared to Normal LDI in long fusions. LDI is a useful measurement that should be considered, especially in high PI patients.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_4 | Pages 23 - 23
1 Apr 2022
Macdonald H Gardner A Evans J Sayers A Whitehouse M
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Dual-mobility constructs (DMCs) are increasingly used for total hip replacement (THR) following hip fracture.

The aims of this study were to identify whether there was a difference in all-cause construct survival following THR with a DMC (DMC-THR) or with a conventional construct following hip fracture, and to identify the expected net all-cause construct survival for DMC-THR performed for hip fracture.

We performed a systematic review and meta-analysis of published studies (including joint registries) including DMC-THR for hip fracture which provided Kaplan-Meier (KM) survival estimates. The primary outcome was all-cause construct survival over time.

318 papers and 17 registry reports were identified. Three studies (two registry reports and one cohort study utilising joint registry data) met the inclusion criteria, including 8,834 DMC-THRs and 63,865 conventional THRs. Upon meta-analysis, DMC-THRs had lower all-cause construct survival. Five-year KM estimates (95% confidence intervals) were 95.3% (94.6–95.9%) for DMC-THR and 96.1% (95.9–96.3%) for conventional THR.

These results suggest there is a small absolute but not clinically significant all-cause implant survival difference between THR with DMC and conventional implants following hip fracture. Given the higher comparative cost of DMC, this analysis does not support its routine use.


The Bone & Joint Journal
Vol. 104-B, Issue 2 | Pages 257 - 264
1 Feb 2022
Tahir M Mehta D Sandhu C Jones M Gardner A Mehta JS

Aims

The aim of this study was to compare the clinical and radiological outcomes of patients with early-onset scoliosis (EOS), who had undergone spinal fusion after distraction-based spinal growth modulation using either traditional growing rods (TGRs) or magnetically controlled growing rods (MCGRs).

Methods

We undertook a retrospective review of skeletally mature patients who had undergone fusion for an EOS, which had been previously treated using either TGRs or MCGRs. Measured outcomes included sequential coronal T1 to S1 height and major curve (Cobb) angle on plain radiographs and any complications requiring unplanned surgery before final fusion.


The Bone & Joint Journal
Vol. 103-B, Issue 5 | Pages 971 - 975
1 May 2021
Hurley P Azzopardi C Botchu R Grainger M Gardner A

Aims

The aim of this study was to assess the reliability of using MRI scans to calculate the Spinal Instability Neoplastic Score (SINS) in patients with metastatic spinal cord compression (MSCC).

Methods

A total of 100 patients were retrospectively included in the study. The SINS score was calculated from each patient’s MRI and CT scans by two consultant musculoskeletal radiologists (reviewers 1 and 2) and one consultant spinal surgeon (reviewer 3). In order to avoid potential bias in the assessment, MRI scans were reviewed first. Bland-Altman analysis was used to identify the limits of agreement between the SINS scores from the MRI and CT scans for the three reviewers.


Bone & Joint Open
Vol. 2, Issue 3 | Pages 198 - 201
1 Mar 2021
Habeebullah A Rajgor HD Gardner A Jones M

Aims

The British Spine Registry (BSR) was introduced in May 2012 to be used as a web-based database for spinal surgeries carried out across the UK. Use of this database has been encouraged but not compulsory, which has led to a variable level of engagement in the UK. In 2019 NHS England and NHS Improvement introduced a new Best Practice Tariff (BPT) to encourage input of spinal surgical data on the BSR. The aim of our study was to assess the impact of the spinal BPT on compliance with the recording of surgical data on the BSR.

Methods

A retrospective review of data was performed at a tertiary spinal centre between 2018 to 2020. Data were collated from electronic patient records, theatre operating lists, and trust-specific BSR data. Information from the BSR included operative procedures (mandatory), patient consent, email addresses, and demographic details. We also identified Healthcare Resource Groups (HRGs) which qualified for BPT.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_2 | Pages 13 - 13
1 Feb 2015
Rogers D Gardner A MacLean S Brown G Darling A
Full Access

Objectives

This paper describes the outcomes obtained from a 12 hour group based multidisciplinary functional restoration programme for patients with persistent low back pain who presented with psychosocial obstacles to recovery. The programme was designed to address modifiable psychosocial obstacles to recovery over a four week period, reduce pain related disability, improve pain self-efficacy and reduce patients' reliance on analgesic medication.

Design

A single group retrospective analysis.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_15 | Pages 1 - 1
1 Oct 2014
Ede MPN Kularatane U Douis H Gardner A James S Marks D Mehta J Spilsbury J
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Neural axis anomalies in idiopathic scoliosis (AIS) are well documented, with prevalence of 7% in adolescents; 20% in early-onset and up to 40% in congenital, the case for pre-operative MRI of brainstem to sacrum is well made in these groups. SK is rarer than AIS and the prevalence of anomalies is not defined. The case for routine MRI scan is unclear. A recent report concluded that routine MRI was not indicated, although this was based on only 23 MRI scans in 85 patients. At our institution all patients are undergo whole spine MRI following a diagnosis of SK. We aimed to assess the incidence of significant neural anomalies in Scheuermann's Kyphosis.

Using a keyword search for “Scheuermann”, we reviewed all SK patients' MRI reports over the past 6 years.

117 MRI scans were identified. 13 patients did not fulfil the radiological criteria for SK and thus 104 (73M: 31F) scans were reviewed. 14 (13%) of 104 scans showed unexpected Significant abnormal findings. There were 8 (8%) with neural axis anomalies: 4 syrinxes; 1 cord anomaly; 2 cerebellar descents and 1 cerebellar tumour. All these patients had normal neurological examination except one with examination consistent with a known diagnosis of Parkinson's. A further 6 patients had non-neural anomalies.

The presence of neural axis anomalies may influence the management of a patient with SK. Neurological compromise during correction is higher in patients with neural axis anomalies and this risk can often be partially mitigated by a preceding neurosurgical procedure (such as foramen magnum decompression or shunt). Furthermore it is well described that these anomalies often occur in patients who demonstrate a normal neurological examination. This study confirms this. Given that MRI is widely available and considering the devastating life implications of neurological injury, we advise pre-operative MRI scan in all SK patents.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_15 | Pages 16 - 16
1 Oct 2014
Ede MPN Kularatane U Douis H Gardner A James S Marks D Mehta J Spilsbury J
Full Access

We describe the prevalence of spondylolisthesis in Scheuermann's Kyphosis (SK) from retrospective review of 104 SK patients over 6 years.

All patients referred to our institution for symptomatic SK undergo MRI scan from hindbrain to sacrum. Our MRI database was reviewed for all SK patients. All scans with spondylolisthesis were re-analysed.

117 scans were identified, 13 patients did not fulfil the MRI criteria for SK and thus 104 (74M: 31F) scans of SK are reported. There were 5 spondylolisthesis (1 cervical and 4 lumbosacral). Of the 4 lumbosacral there were 2 Meyerding grade-1; 1 grade-2 and 1 grade-5 spondyloptosis). An overall rate of 5% for listhesis was therefore found.

The prevalence of spondylolisthesis is around 3% in the general population based on a CT study of 510 patients (Belfi 2006) and Fredrickson's (1984 and 2003) prospective study of 500 children. We describe the prevalence in SK patients being higher at 5%. This may be related to the adaptive change of increased lumbar lordosis in SK, certainly it supports the previous description higher rates of spondylolysis in SK.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_6 | Pages 1 - 1
1 Apr 2014
Price A Gardner A Baker D Berryman F Pynsent P
Full Access

Aim:

AIS causes a loss of trunk height. This paper documents this loss against sitting height standards and assesses formulae for adjusting height loss back to the standard.

Methods:

A total of 334 patients (84% female) with AIS and no other known systemic disease had sitting height measured. This was compared to standards of sitting height with age and the ratio of height to sitting height with age (HSH).

The corrected height was calculated using published formulae and replotted against these standards.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 318 - 318
1 Dec 2013
Gardner A Angibaud L Stroud N
Full Access

Introduction

Ideally, a patient receiving a unicondylar knee replacement will have fully functional anterior and posterior cruciate ligaments. When at least one of the cruciate ligaments is not fully functional, femoral and tibial implant contact position can potentially increase along the anterior-posterior (AP) axis. Where unicondylar implant wear testing typically uses AP resistance assuming fully functional cruciate ligaments, the authors used reduced AP resistance intended to simulate deficient cruciate ligaments.

Methods

Optetrak Logic® Uni (Exactech Inc, Gainesville, FL USA) unicondylar test specimens featuring an all-UHMWPE tibial component and a cobalt chromium femoral component were used in this study. The system has a semi-constrained articular geometry. Testing was conducted at an independent testing facility (EndoLab GMBH, Thansau, Rosenheim, Germany). A four-station knee simulator was used (EndoLab knee simulator) with two unicondylar knee implants per station, giving a total of eight test specimens. Two different tibial fixation designs (keeled and peg) with identical articulating surfaces were tested. Tibial test specimens were 6 mm in thickness. Unloaded soak controls were stored in distilled water at 37°C. The test was conducted according to ISO 14243–1: 2009 [1]. Test specimens were immersed in calf serum (PAA GmBH, Cölbe, LOT B00111-5126) with a protein content of 20 g/l. Custom polyurethane molds allowed for individual component measurement. Per the ISO 14243-1, a 7% medial offset was incorporated into the set-up. The unicondylar knee implants were set at neutral position in extension. Tibial rotational restraint was 0.36 Nm/° and zero when the test specimen was within ± 6° of the reference position. This test was conducted with an AP resistance of 9.3N/mm to maximize AP displacement and simulate deficient cruciate ligaments. Typical unicondylar knee wear testing is conducted with an AP resistance of 44N/mm, which assumes functional cruciate ligaments.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXVII | Pages 22 - 22
1 Jun 2012
Kotecha A Berryman F Baker D Pynsent P Gardner A Marks D Spilsbury J
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Introduction

Monitoring of scoliosis is traditionally done with radiographs, which can be associated with an increased risk of cancer secondary to multiple exposures over many years. This study investigated whether the findings from surface topography can be used to monitor scoliosis curves and how much this method affects outcome scores in patients with scoliosis. This study therefore had two subsets: (1) to investigate whether lateral asymmetry (LA) from ISIS2 surface topography can predict radiographic Cobb angle, providing an alternative non-invasive means of monitoring patients with scoliosis (LA and Cobb subset); and (2) to establish the relationships between the magnitude of the deformity in scoliosis, measured by Cobb angle on radiograph and volumetric asymmetry (VA) with the ISIS2 surface topography, and the patient perception of self-image and mental health, measured with SRS-22 scores (Cobb, VA, and SRS subset).

Methods

In the LA and Cobb subset, 72 untreated patients with scoliosis (77 curves) with a Cobb angle of 55° or less were included in the study. They had clinical assessment, Cobb angle measurement taken from a standard radiograph, and surface topography done on the same day. A comparison of Cobb angle and LA was done. In the Cobb, VA, and SRS subset, 89 untreated patients with scoliosis were included in the study. They had clinical assessment, Cobb angle measurement of radiograph, and surface topography done on the same day along with SRS-22 questionnaires. A comparison correlation of SRS scores for function, pain, self-image, and mental health against Cobb angle and VA was undertaken. All statistical analysis was done with software R.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XX | Pages 1 - 1
1 May 2012
Kotecha AK Berryman F Baker D Pynsent P Gardner A Marks D Spilsbury J
Full Access

Purpose of the study

To establish the relation between the magnitude of the deformity in scoliosis, measured by cobb angle on radiograph & Volumetric asymmetry with the ISIS2 surface topography, and the patient perception of self image and mental health, measured with SRS-22 scores.

Methodology

A total of 89 untreated patients with scoliosis were included in the study. They had clinical assessment, cobb angle measurement of radiograph and surface topography performed on the same day along with SRS-22 questionnaires. The cobb angle was measured by single surgeon using a digital PACS system, who was unaware of the volumetric asymmetry score. Volumetric asymmetry was measured by ISIS2 surface topography performed by a research nurse who was unaware of the cobb angle. Volumetric asymmetry was calculated using standard ISIS2 software. A comparison correlation of SRS scores for function, pain, self image and mental health against cobb angle and volumetric asymmetry was undertaken by clinical scientist. Scores for patient satisfaction to treatment was excluded as these were untreated patients. Statistical analysis was performed using cor. test on software R


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XX | Pages 2 - 2
1 May 2012
Kotecha AK Berryman F Baker D Pynsent P Gardner A Marks D Spilsbury J
Full Access

Purpose of the study

Monitoring of scoliosis is traditionally done with radiographs which can be associated with an increased risk of cancer secondary to multiple exposures over many years. This study investigates whether lateral asymmetry (LA) from ISIS2 surface topography can predict radiographic cobb angle, to provide an alternative non- invasive means of monitoring scoliosis patients.

Methods

A total of 72 untreated patients with scoliosis (77 curves) with a Cobb angle of 55 degrees or less were included in the study. They had clinical assessment, cobb angle measurement taken from a standard radiograph and surface topography done on the same day. The cobb angle were measured by single surgeon using digital PACS system. The surgeon was unaware of the LA score. Lateral asymmetry was measured using ISIS2 surface topography done by a research nurse who was also unaware of the cobb angle as previously described. Lateral asymmetry was calculated using the standard ISIS2 software. A comparison of cobb angle and LA was performed.

Linear regression analysis was performed to define an equation predicting Cobb from LA. The predicted Cobb angles were then compared with the measured radiographic Cobb angles using Bland-Altman analysis. All statistical analysis was carried out using R.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_X | Pages 29 - 29
1 Apr 2012
Gardner A Spilsbury J Marks D Thompson A Miller P Tatman A
Full Access

Reviewing our experience of scoliosis in children with a Cavopulmonary Shunt or Fontan circulation and the cardiovascular challenges that this presents.

A notes and x ray review was performed. Special attention was paid to the changes in cardiovascular status whilst prone. The review was from first presentation to latest follow up.

There were 6 patients who underwent 7 major procedures between 2001 and 2009. All had cardiac procedures in early life. Both definitive fusion and growing instrumentation was used. All procedures were successful. Growing instrumentation allowed earlier primary surgery before completion of the Fontan circulation. All have been subsequently lengthened in a lateral position. The mean follow up is 56 months. There was one death 40 months following last surgery, cause unrelated to spinal surgery.

In the older patients with a completed Fontan significant blood loss was seen, due to the raised venous pressure required to run the Fontan, and occult hypotension seen as a climbing difference between Pulmonary Artery Wedge Pressure and Central Venous Pressure were common when prone.

We recommend early intervention, using instrumentation without fusion to correct the deformity over time and allow intervention prior to completing the Fontan circulation. As haemodynamic instability increases with increasing time in the prone position, surgery should be expedited rapidly.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_X | Pages 103 - 103
1 Apr 2012
Choudhury M Siddique I Gardner A Spilsbury J Marks D
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Spinal Deformity Service, Royal Orthopaedic Hospital, Birmingham, UK

To describe the technique of nonfusion annulotomy and nuclectomy with posterior growing rod instrumentation for the treatment of non-congenital early onset scoliosis

To present our results of the application of this technique in a consecutive series of nine patients with mean follow up of 76 months (range 16 to 123 months)

We undertook retrospective observational casenote and radiograph study of patients with noncongenital early onset scoliosis having annulotomy and nuclectomy at the apex of their respective curves with standard posterior growing rod instrumentation between 1998 and 2009.

10 patients were identified with one excluded due to short follow up period. Of the nine patients included mean follow up was 76 months. Mean age at primary surgery was 71.7 months (range 29- 97 months)

We measured pre and post operative Cobb angle, T1-S1 height change and change in height over the apical segments.

Mean pre op cobb angle was 74° (range 62- 81°). Mean post op cobb angle was 38°. Three patients have completed their treatment programme with a mean number of 9 lengthenings achieved. Six patients are still undergoing lengthenings. CT demonstrates that the annulotmized segment does not fuse at a mean 3.5 years postoperatively. All patients demonstrated growth over total spinal height and also over apical segments which had undergone annultomy/ nuclectomy. We also report complications.

We have demonstrated that anterior annulotomy and nuclectomy with posterior growing rod construct does allow for spinal growth over released segments without autofusion.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 425 - 425
1 Jul 2010
Loughenbury P Brooke B Gardner A Berry L Rao A Dunsmuir R Millner P
Full Access

Purpose of the study: To investigate whether autologous blood transfusion (ABT) drains and peri-operative cell salvage reduce allogeneic transfusion requirements for scoliosis surgery in our unit.

Methods: Prospective data collection on transfusion requirements of patients undergoing scoliosis surgery between January 2006 and February 2008. Cases were split into three groups, representing recent stepwise changes in transfusion practice. Group A received ‘traditional treatment’ of allogeneic red cell transfusion (ARCT) in response to intra- or post-operative anaemia (Hb< 8g/dL or symptomatic anaemia). Group B received peri-operative cell salvage in addition to ‘traditional treatment’. In group C, ABT wound drains were used alongside peri-operative cell salvage and ‘traditional treatment’.

Results: ARCT was required for 23 of the 35 procedures (66%) in group A, 22 of 37 (59%) in group B and 10 of 20 (50%) in group C. Where patients required ARCT, those in group C received fewer units (mean 2.6) than group B (mean 3.1) and group A (mean 3.7). There was no difference in mean preoperative haemoglobin levels (A – 13.56g/dL SD 1.36; B – 13.35g/dL SD 1.46; C – 13.94g/dL SD 1.25). Mean length of inpatient stay was lowest in group C (9.11 days), and lower in group B (12.02) than group A (13.75).

Conclusion: Use of ABT drains and peri-operative cell salvage lead to reduced allogeneic transfusion needs for scoliosis surgery in our unit. Lowest transfusion rates were seen when both were used together, leading to a 16% reduction in the need for ARCT.

Ethics approval: None

Interest Statement: None


The Journal of Bone & Joint Surgery British Volume
Vol. 91-B, Issue 9 | Pages 1252 - 1255
1 Sep 2009
Gardner A Millner P Liddington M Towns G

The spinal manifestations of neurofibromatosis include cervicothoracic kyphosis, in which scalloping of the vertebral body and erosion of the pedicles may render conventional techniques of fixation impossible. We describe a case of cervicothoracic kyphosis managed operatively with a vascularised fibular graft anteriorly across the apex of the kyphus, followed by a long posterior construct using translaminar screws, which allow segmental fixation in vertebral bodies where placement of the pedicle screws was impracticable.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 490 - 490
1 Sep 2009
Gardner A Haden N Millner P Rao A Dunsmuir R Dickson R
Full Access

Abstract: It is known that the treatment of intra or extraspinal paediatric tumours with surgery and radiotherapy or radiotherapy alone can lead to the onset of progressive spinal deformity the management of which can be extremely challenging. We review our series of patients who have developed a spinal deformity in these circumstances.

Methods: A review of all patients seen between 1996 and 2007 in the spinal department who have developed a significant spinal deformity following treatment for an intra or extra spinal tumour.

Results: 14 patients were identified. The age of presentation to the spinal service was between 2 years 6 months and 15 years 3 months. The underlying diagnoses were Wilms Tumour treated with surgery and radiotherapy in 3, 1 extraspinal sarcoma treated with surgical resection, radiotherapy and chemotherapy, 1 extraspinal neuro-blastoma treated with surgery, radiotherapy, chemotherapy and stem cell rescue and 9 intra spinal tumours (PNET, astrocytoma, ganglioneuroblastoma and der-moid) all managed with resection with or without radiotherapy. The spinal deformities that have developed were thoracic kyphoscoliosis, thoracolumbar kyphosis and lumber hyperlordosis. The spinal management of these deformities has been conservative in 12 with regular assessment to allow intervention if indicated. 2 patients have undergone surgery, a vascularised fibular strut graft and anterior instrumentation in 1 and a non vascularised rib graft in 1 for progressive deformity felt to lead to neurological dysfunction or lung hypoplasia. The cases managed operatively were complicated by poor posterior soft tissues following previous surgery and radiotherapy requiring an anterior approach. In all patients who were treated with radiotherapy platyspondyly was always seen in the vertebral bodies anteriorly and this corresponded to the apex of the deformity.

Conclusion: In all children who undergo spinal surgery and or radiotherapy for paediatric tumours there must be ongoing surveillance for the development of a spinal deformity. We feel that this is as much a result of anterior growth arrest secondary to radiotherapy as to posterior laminectomy for intra canal tumour excision. The surgical management of this problem is complex and may require innovative solutions.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 487 - 487
1 Sep 2009
Haden N Gardner A Millner P Rao A Dunsmuir R Dickson R
Full Access

Introduction: The natural history of scoliosis in the presence of a cord syrinx, either treated conservatively, or post surgically, is disputed. It is generally believed to be associated with a greater likelihood of rapid deformity progression pre-operatively and a much greater likelihood of intraoperative neural injury.

In this study we aimed to retrospectively assess the local experience by reviewing patients, treated over the last 10 years, in whom scoliosis has been established, by means of MR imaging, to be associated with a cord syrinx.

Methods: A retrospective cohort study was undertaken of paediatric patients attending the Leeds Spinal Unit between the years of 1997 and 2007. The entry criteria for this study were spinal deformity with MRI proven cord syrinx, in a patient without underlying tumour or other cord anomaly. Given the association with Chiari malformation this was a measured parameter rather than exclusion criteria. Other parameters assessed were mode of presentation, progression of scoliosis, details of the identified syrinx, chosen mode of treatment for the syrinx and the scoliosis (including conservative) and outcome measures (neurological function and sequelae, change in Cobb angle/deformity correction).

Results: A total of 46 patients were identified with scoliosis and an associated syrinx. The age range was from 3 to 18 years. Only 12 were male. The syrinx was associated with an Arnold Chiari malformation in 24% of patients, and located at the apex of, or local to, the maximum deformity in 73%.

The syrinx was treated surgically in 10 patients, with 80% of these achieving either deformity arrest, or no longer requiring surgical deformity correction. In the 2 patients from the same subset who did undergo deformity correction there was no neurological sequelae. Of the conservatively managed syrinxes, deformity correction with intraoperative cord monitoring was nevertheless undertaken in 31%, all without neurological sequelae. In just 4 patients (of 69%) who did not proceed to deformity correction, surgery was precluded by the inherent risks in the presence of an untreated syrinx.

Conclusion: This small series does not lend support to the literature and anecdotal evidence for significantly increased surgical risk in deformity correction without treatment for syrinx first. However, this may reflect the fact that all syrinxes likely to compromise the surgical procedure were assessed as such and treated first. In the cohort of patients whose syrinxes were treated conservatively, a significant proportion did not require subsequent deformity surgery. Identifying a syrinx by, the mandatory, MR imaging of a patient with a deformity before considering surgical correction, appears to identify a significant proportion of syrinxes which neither significantly accelerate the progression deformity, or which do not lead to poor outcome after deformity surgery.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 492 - 492
1 Aug 2008
Gardner A Hettinga D
Full Access

Many studies in UK and other countries over the past 15 years have shown a high one year prevalence of back pain in teenagers rising from around 12% at the age of 12 to adult levels in excess of 30% by the age of 19.

Around 8% of all adolescents are significantly affected by chronic or recurrent back or neck pain sufficient to compromise school attendance and/or sport. Girls report around 10% more disability than boys.

Adolescent back pain, especially when accompanied by MRI changes at the age of 15, is associated with continuing symptoms in adult life.

Associated risk factors are physical, environmental, psychosocial and genetic. Some of these can be rectified, others clearly cannot, but once identified, they can usually be managed satisfactorily to minimise disability.

Known physical factors include too little or occasionally too much exercise, also many schools do not have adequate lockers which necessitates carrying heavy loads of books, sports equipment, etc. often in inadequate bags. A maximum load of 15% of body weight is recommended.

Environmental factors include poorly designed lowest cost school furniture causing postural strain, which cannot be adjusted to take account of the half metre variation in height of 15 year olds. One size does not fit all. Much school furniture would be illegal in an office, School is the workplace of the child.

This paper reviews the recent literature which indicates that attention to these factors results in better school performance and less back pain but further research is required.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 153 - 153
1 Apr 2005
Datta A Gardner A Bell K
Full Access

Purpose of Study- To deliver high quality and high volume major joint replacement surgery through rigorous infection control and reduce both infective complications and late cancellations.

Deep infection complicating arthroplasty surgery carries a heavy fnancial and emotional burden on any orthopaedic service. The cost of hospital acquired infection is estimated at £1 billion per year 1 by the National Audit Office.

Healthcare associated infection is an area currently under great scrutiny. Each NHS trust will have an Inspector of Microbiology, who will ensure the co-ordination of information required to diagnose healthcare associated infection.

The Alexandra Hospital, Redditch has developed a dedicated elective orthopaedic ward free from multi resistant staphylococcus aureus (MRSA). that delivers high quality and high volume major joint replacement surgery through rigorous infection control.

Between October 2001 and December 2002, the Alexandra hospital had an infection rate of 0.21% for total knee replacements compared to the national rate of 2.1% p= 0.002 (CI 0.00005–0.01) The infection rate for total hip replacements was 1.31% compared to 3.8% nationwide. p = 0.01 (CI 0.004–0.03).

The total number of joint replacements performed per year increased from 256 in 2000 to 629 in 2002.

We have developed a safe, effective and efficient orthopaedic unit within the framework of an NHS trust for a relatively modest investment. We believe the practical changes that have been made within our department can be repeated in other units around the country with relative ease.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 194 - 194
1 Mar 2003
Gardner A
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Introduction: In 1998 the British Scoliosis Society was asked by the Board of Affiliated Societies to the BOA to provide information concerning the activity, numbers and training implications for specialists in our field. We had no systematic data so with the valuable assistance of the BOA a survey of spinal surgery activity was undertaken amongst 187 Orthopaedic Surgeons who had declared spinal surgery as a main interest in a previous BOA survey. One hundred and fifty questionnaires were returned (80.2%). This data was collated and analysed by the Statistical Department of the British Orthopaedic Association.

As a result of the information obtained a template for the organisation of management of spinal disorders in UK and its manpower implications was developed. This template was then circulated to the Presidents of all the British Spine Societies for consideration at their AGMs in 1999. There was widespread support. It is understood that the BOA have also discussed these proposals along with those from other affiliated societies and it is perhaps time for further action.

Methods and results: The results from the postal questionnaires were analysed along with information from other sources. Fifty-five surgeons were identified as being Specialist Spinal Surgeons (greater than 70% of their time), 120 Surgeons were designated Surgeons With An Interest (greater than 30% of their time), 25 Surgeons spent less than 30% of their time on spines. Sixty-two per cent (93 Surgeons) considered their facilities for spinal work were adequate, 34.7% (52) considered that they were inadequate and 3.3% (5) said that they were unacceptable. Forty-nine per cent (73) of those responding employed a triage system with 58.5% using a physiotherapist and 16.2% using a nurse. Five point nine per cent used a clinical assistant and 19.1% of triage was done by the Spinal Surgeon.

Regarding outpatient waiting times, 31% of Surgeons had a waiting time of three to six weeks for urgent appointments with 20% longer than six weeks. Sixty per cent had a waiting time of over six months for non urgent consultations. For urgent but not emergency surgery 70% had a waiting time of over three weeks and half of those were over six weeks. For non urgent spinal surgery 70% were waiting more than six months with 50% waiting more than nine months.

Conclusion: Our limited manpower and resources must be used with maximum efficiency while we wait for the inevitably slow build up to international best practice which is likely to take at least ten years with a fair wind.

The Template: 20 Regional Spine Centres each with at least five Specialist Spinal Surgoens (SSS) including one or two Neurosurgeons, total 100 Surgeons.

Sixty-five District Spine Centres (at least three per Region) with at least two Surgeons With An Interest (SWI) (Orthopaedic or Neuro), total 130 Surgeons. At present we have 55 SSS of whom 18 will be retired by 2005. We have around 120 SWI of whom only nine will be retired in 2005 taking retirement age at 65. We therefore have a shortfall of 63 SSS and perhaps 10 SWI a number of whom may wish to upgrade to SSS. According to Okafor and Sullivan (1998) the average European country of our size would have 150 SSS compared with our 55.

1.There is an urgent need for more Orthopaedic Surgeons and in particular Spinal Surgeons.

2.Surgeons need adequate facilities and infrastructure to allow them to work efficiently. Finance is required.

3. Until the training base for future Specialists involved in the management of spinal disorders is steadily expanded from bottom to top, little progress can be expected.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 194 - 194
1 Mar 2003
Conn K Sharp D Gardner A
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Introduction: In order to improve the provision of Spinal Surgery in the United Kingdom, the number of Specialist Spinal Surgeons and Surgeons with an Interest in Spinal Surgery needs to increase by 25% from the existing 175 surgeons. There is an expected shortage of Orthopaedic Specialist Registrars (SpRs) planning careers in Spinal Surgery not only to maintain the status quo, with one third of Specialist Spinal Surgeons due to retire in the next three years, but also to provide the needed expansion in numbers.

Methods and results: A postal survey of the 528 SpRs was performed with a response rate fo 71%. The critical question was the post accreditation intention as either a Specialist Spinal Surgeon (greater than 70% of elective work), as a Surgeon with an Interest in Spinal Surgery (more than 30% of elective work), a surgeon doing occasional Spinal Surgery (less than 30% of elective work) or one who avoids all Spinal Surgery. This attitude could then be taken into account when analysing the training provided and the perceptions of Spinal Surgery to identify factors which could be discouraging an interest in Spinal Surgery.

Sixty-nine per cent indicated that they intended to avoid all Spinal Surgery. Thirty-five (9%) intended becoming either Specialist Spinal Surgeons or Surgeons with a Spinal Interest but only nine (2%) are in their final two years of training. The declared intention to avoid Spinal Surgery increases from 54% in the first two years of training, to 70% in the middle two years, and to 75% in the final two years and post C.C.S.T. fellowships. There should be 24 newly accredited Specialist Spinal Surgeons based on a projection of the 4.3% response intending to become Specialist Spinal Surgeons. This leaves a shortfall of 34 Specialist Spinal Surgeons by 2005.

The survey has revealed three main features of Spinal Surgery which appear to have a negative effect on the attitude of the SpRs to Spinal Surgery and overwhelm the potentially attractive features. These are badly organised clinics; the perceived psychological complications of spinal patients; and a perceived inadequate exposure to Spinal Surgery during their training.

Conclusion: It is clear from the response of SpRs that there are important misconceptions concerning Spinal Surgery, together with the shortcomings of training and of the provision of services within the NHS. These have to be addressed urgently if the speciality is to become more attractive to them. Areas where positive action can be taken include the modification of training programmes so that all SpRs are exposed to Spinal Surgery in the formative first three years; properly structured spinal clinics; and above all the need for Spinal Surgeons to be encouraging and enthusiastic about a field of surgery which provides some of the exciting challenges in Orthopaedic Surgery.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 274 - 274
1 Nov 2002
Khan R. Crossman P MacDowell A Reddy N Gardner A Keene G
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Aim: To establish the surgical treatment of displaced intracapsular femoral neck fractures in hospitals across the United Kingdom.

Methods: The on-call registrars in all 223 hospitals receiving acute orthopaedic admissions in the UK, were interviewed by telephone. Their usual practices were recorded for two groups of patients, active and frail. The proportions of hospitals using the different surgical options were determined.

Results: Despite stereotyped clinical features, management varied between specialists within some hospitals: two or more different methods of treatment were in routine use for active patients in 22% of hospitals, and for frail patients in 27%. The management also varied between hospitals. Overall, for active patients, bipolar hemiarthroplasty was in use in 41%, internal fixation in 37%, unipolar hemiarthroplasty in 32% and total hip replacement in 16% of hospitals. For frail patients either Austin-Moore or Thompson prostheses or both were in use in 94% of hospitals. Where used, Austin-Moore prostheses were uncemented in 93% of hospitals, and Thompson prostheses cemented in 79%. Bipolar prostheses were in use in 8%, and the alternative of internal fixation undertaken for frail patients in 1% of hospitals.

Conclusions: The findings demonstrated a lack of consensus in several aspects of the treatment of displaced intracapsular fractures of the femoral neck, with implications for consideration of best practice, in the UK, and worldwide.


The Journal of Bone & Joint Surgery British Volume
Vol. 72-B, Issue 5 | Pages 810 - 815
1 Sep 1990
Gardner A Fox R Lawrence C Bunker T Ling R MacEachern A

Following the discovery of a powerful venous pump in the foot that is activated by weight-bearing independently of muscular action, a pneumatic impulse device was developed to actuate this pump artificially. In a multicentre international trial the device was shown to reduce post-traumatic and postoperative swelling; pain also was alleviated. Evidence is also presented that dangerously high compartment pressures may be reduced to acceptable levels and fasciotomy avoided. We present an explanation of the clinical effects of activation of the venous footpump, based on recent improved understanding of the physiology of the microcirculation. The hyperaemic response that follows the liberation of endothelial-derived relaxing factor (EDRF) by sudden changes of pressure after weight-bearing or impulse compression is particularly important.