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Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 78 - 78
1 Jan 2011
Joseph JJ Pillai A Ritchie D McDuff E Mahendra A
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Introduction: Bizarre parosteal osteochondromatous proliferation(BPOP) is a benign lesion of bone originally described by Nora et al in 1983. To date there are no UK-based case series in the literature. Here we present the Scottish Bone Tumour Registry(SBTR) experience of this rare lesion.

Method: A retrospective analysis of SBTR records was performed.

Histological specimens were re-examined by a consultant musculoskeletal oncology pathologist. Radiographs were re-reported by a consultant musculoskeletal radiologist.

Results: From 1983–2009, 13 cases were identified; 6 male, 7 female. Age ranged from 13–65.

All patients presented with localised swelling. Pain was present in 5 and trauma in 2.

9 lesions affected the hand, 3 the foot, and 1 the tibial tuberosity.

12 lesions were excised and 1 curetted. There were 7 recurrences of which 6 were excised. 1 patients’ recurrence was not treated. 1 lesion recurred a second time. This was excised. There were no metastases.

Radiographs typically showed densely mineralised lesions contiguous with an uninvolved cortex. Cortical breakthrough was present in 1 case and scalloping in another.

Histology characteristically showed: hypercellular cartilage with pleomorphism and alcification/ossification without atypia; bone undergoing maturation; and a spindle-cell stroma.

Discussion: SBTR records indicate that BPOP is a rare lesion with no sex predilection that affects patients over a wide age range.

Minor antecedent trauma was present in only 2 cases. In agreement with Nora et al. we feel that trauma is unlikely to represent an aetiological factor.

Recurrence was over 50% in this series. Although this is similar to that found in other reports, it may indicate that more extensive resection is required for this aggressive lesion.

Finally, although radiological/histological findings are often bizarre there have been no reported metastases and so it is important that BPOP is not mistaken for, or treated as, a malignant process such as chondrosarcoma.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 336 - 336
1 May 2010
Pillai A Nunag P Diane B
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Background: Selective ultrasound screening of neonatal hips with risk factors has been undertaken in Lanarkshire from 2001. Referral reasons included family history, breech, clicky hip and instability. Patients are examined by an orthopaedic surgeon with a special interest and scanned by static Graf technique. Our experience with selective screening and its effect on late DDH is presented.

Methods: All ultrasound screening data was collected prospectively and entered into a database. Late presenters were identified at the tertiary centre by case note and X ray review. Population data was obtained from the Scottish registry.

Results: Between 2001–2005, there were 30,824 live-births. 405 babies (910 hips) were identified as being at risk. 5(1.2%) were identified as Graf III/IV. Three responded to splinting, 1 required closed reduction and 1 open reduction. 11 who had initially normal scans were noted to have abnormal acetabular index (> 30) at 6 months. 2 required open reduction, 1 closed reduction and the rest eventually normalised with follow up. True late presentation was identified (> 3 months) in 11 children. Mean age at diagnosis was 14.7m (4–29 mts). 7(64%) did not have any identifiable risk factors. 4 had risk factors, but had escaped screening. 8 underwent open and 3 closed reduction. 7 derotation osteotomies and 1 pelvic osteotomy were additionally performed.

Discussion: The identifiable incidence of DDH in Lanarkshire is 0.87/1000. The incidence of true late presenting DDH in the same population was 0.35/1000. If all hips with risk factors had been successfully screened it would reduce to 0.22/1000. Selective screenings can minimise the incidence of late presenting DDH if rigorously implemented. Majority of late presenters do not have risk factors and are likely to escape detection with a selective screening programme. This suggests a different natural history in late presenting cases.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 59 - 59
1 Mar 2009
Pillai A Bramley D
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Background: DDH represents a spectrum of anatomical abnormalities in which the femoral head and the acetabulum are either in improper alignment or grow abnormally. Although screening leads to earlier identification, 60–80% of abnormal hips of newborns identified by physical examination resolve spontaneously by 2–8 weeks and 90% of the hips of newborns with mild dysplasia identified by ultrasound resolve spontaneously between 6 weeks and 6 months.

Aims: To assesses accuracy of ultrasound screening of neonatal hip by the static technique of Graf. We attempt to answer the question whether routine radiological follow up of these children are indicated.

Methods: Since 2001, we have performed selective ultrasound screening of over 600 neonates (1200 hips). The reasons for referral included, breech presentation, clicky hip, unstable hip, dislocation, foot deformity and family history of DDH. Clinical examination, followed by serial ultrasound examinations at presentation, 6 weeks and 3 months of age were carried out. A radiological examination and measurement of the acetabular index was performed at 6 months of age. Hips were classified according to the 4 Graf types. We compared the ultrasound findings with the acetabular index (AI) for individual patients.

Results: All children were followed up prospectively from presentation to discharge. For neonates without any family history of DDH and normal clinical examination (symmetrical skin creases, equal limb lengths, unrestricted abduction and no instability demonstrated on the Ortolani and Barlow manoeuvres) the ultrasound classification according to Graf co-related with the acetabular index on 6 month radiographs. 100% of hips with normal scan (Graf I) both at 6 weeks and at 3 months of age had a normal AI.

Discussion: The static technique of Graf is an accurate and reliable method of assessment of neonatal hips. In children with normal clinical examination, and no family history of dysplasia, scan findings are a good predictor of the AI. Routine radiological follow up in such patients is not necessary.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 134 - 134
1 Mar 2009
Malal JG Pillai A Nimon G
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Background: Hip fracture is a serious injury mainly affecting the elderly population. The injury has a high mortality of 30% at 1 year and also has a major impact on the quality of life of the survivors. The Scottish Hip Fracture Audit has identified significant difference in the level of care provided in hip fractures between different hospitals and regions. The study aims to assess the impact of the experience of the operating surgeon on the long term outcome of hip fractures taking a cemented bipolar hip arthroplasty as an index procedure.

Materials and Methods: All patients who had the index procedure carried out over an eight year period at the Dumfries and Galloway Royal Infirmary were included in the study. Their preoperative mobility and health status along with the experience of the surgeon performing the procedure were determined. The outcome assessment was carried out using a modified Harris hip score.

Results: 46 patients were followed up at a mean of 45 months (range 16 to 109). One patient required a revision for aseptic loosening. Of the remaining, 18 procedures were carried out by consultant surgeons and 27 by trainees unsupervised. There was no statistical difference in the age, sex, ASA grade, preoperative mobility level or duration of follow up between the two groups of patients. The mean hip score at the time of follow up for the consultant group was 67.2 and 52.6 for the trainee group. This was statistically significant with a P value < 0.05.

Conclusion: The proportion of hip fracture surgeries done by, or under the direct supervision of a consultant orthopaedic surgeon vary widely between various Scottish hospitals (20% to 90%). The significant difference in long term out come of the procedure based on the surgeon’s experience calls for greater supervision and training of juniors.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 36 - 36
1 Mar 2009
Pillai A Nimon G Dreghorn C
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Background: After Jules-Emile Pean and Neer, unconstrained prosthetic arthroplasty of the shoulder is widely used for glenohumeral osteoarthritis (OA), rheumatoid arthritis (RA) and trauma. While the debate continues over whether humeral head replacement (HHR) or total shoulder arthroplasty (TSR) is better for OA and RA, hemiarthroplasty is preferred in the trauma situation.

Aims: A retrospective review (1993–2000) of 54 patients with the DePuy Global second generation modular shoulder hemiarthroplasty is presented. We highlight the various complications encountered in the longer term and attempt to use our experience to rationalize treatment choice.

Methods: 49 shoulders in 41 patients were available for review. Case records and radiographs were reviewed and clinical assessment carried out. Functional assessment was done using the Constant (CM) and the American Shoulder and Elbow Society systems (ASES). Patients were also asked to complete a shoulder self assessment questionnaire (Insalata, Hospital for Special Surgery).

Results: The pre-op diagnosis was 20 RA, 12 OA, 11 trauma. The mean age was 63.4Yrs. The mean follow up was 6.8Yrs (4–11 Yrs). The mean Constant scores for the 3 groups were 48.1 RA, 46.3 OA, and 56.6 trauma. The mean ASES functional scores were 39.6 RA, 37.5 OA and 32.9 trauma. Active elevation in the RA group was a mean of 83.5°, and 69.5° for OA and 79° for the trauma group. 65% of the RA group was completely pain free compared to 50% and 54% in the OA and trauma groups respectively. Patient satisfaction was high in the RA and OA groups but poor in the trauma group. 90% of RA patients had evidence of superior migration of the prosthesis (ASM), with the majority of them developing cuff dysfunction. 36% of trauma patients had tuberosity escape/nonunion. 100% of OA patients developed late glenoid erosion. Presence of secondary glenoid arthrosis and ASM co-related with poor function (r =0.5, p< 0.05).

Discussion. Second generation prosthesis can prejudice the shoulder biomechanics. Over-tensioning the joint can lead to both glenoid wear and cuff rupture.

In OA patients, satisfaction was highest, but function was poor. Patients with out cuff tear pre-operatively did not develop it later. They may thus benefit from a TSR compared to HHR. RA patients had the least pain, best function and high satisfaction. Most had evidence of either primary or secondary cuff dysfunction. In them patients HHR may be the preferred option. Trauma patients did poorly in all respects. More anatomical reconstruction and greater emphasis on salvage of the humeral head is required in this group.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 215 - 215
1 Jul 2008
Pillai A Shenoy R Reid R Tansey P
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Introduction: Frozen shoulder is a general term denoting all causes of motion loss in the shoulder. As the syndrome is very common, many patients do not undergo detailed imaging studies before treatment.

Objectives: A series of 15 patients with primary neoplasms of the shoulder girdle mimicking frozen shoulder syndrome is presented.

Results: There were 6 male and 9 female patients. The common presentation was pain and stiffness of the shoulder joint. Mean age at diagnosis was 46.63Yrs (range 23 “ 71 Yrs). 73% were less than 50 Yrs of age. Only 2 gave history of trauma. Most received local steroids and physiotherapy before diagnosis. There were 10(66.6%) proximal humeral lesions and 5(33.3%) scapular lesions. Humeral lesions included chondrosarcoma (2), Ewing’s (2), lymphoma (2), chondroma (2) and osteoblastoma (1). Scapular lesions included chondrosarcoma (3), lymphoma (1) and fibromatosis (1). Scapular tumors involved older individuals. The mean delay in diagnosis after onset of symptoms was 15.8 mts (range 2 weeks- 48 months). All patients had X rays and CT / MRI. Treatment included a combination of surgery, chemotherapy and radiation. 3 patients with humeral lesions died at a mean of 20.6 mts, and 3 patients with scapular lesions died at a mean of 4.3 mts after diagnosis. The common cause of death was pulmonary metastasis.

Discussion: Many so called frozen shoulders are joints inhibited by pain rather than by true contracture. The commonest lesion to mimic a frozen shoulder is a slow growing low/middle grade chondrosarcoma. Young patients presenting with persistent pain or night pain must be examined for this possibility. Consideration should be given for further investigation before instituting treatment. Delay in diagnosis adversely affects survival. Surgeons are reminded that although rare, a tumor should be suspected when clinical presentations are unusual.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 292 - 292
1 May 2006
Pillai A Shenoy R Ried R Tansey P
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Introduction: Frozen shoulder is a general term denoting all causes of motion loss in the shoulder. As the syndrome is very common, many patients do not undergo detailed imaging studies before treatment. Some patients are managed by their GPs for long periods before being referred to a hospital.

Objectives: A series of 15 patients with primary neoplasms of the shoulder girdle mimicking frozen shoulder syndrome is presented.

Methods: A retrospective review of the Scottish bone tumor registry.

Results: There were 6 male and 9 female patients. The common presentation was pain and stiffness of the shoulder joint. Mean age at diagnosis was 46.63Yrs (range 23 – 71 Yrs). 73% were less than 50 Yrs of age. Only 2 gave history of trauma. Most received local steroids and physiotherapy before diagnosis. There were 10(66.6%) proximal humeral lesions and 5(33.3%) scapular lesions. Humeral lesions included chondrosarcoma (2), Ewing’s (2), lymphoma (2), chondroma (2) and osteoblastoma (1). Scapular lesions included chondrosarcoma (3), lymphoma (1) and fibromatosis (1).Scapular tumors involved older individuals. The mean delay in diagnosis after onset of symptoms was 15.8 mts (range 2 weeks- 48 months). All patients had X rays and CT/MRI. Treatment included a combination of surgery, chemotherapy and radiation. 3 patients with humeral lesions died at a mean of 20.6 mts, and 3 patients with scapular lesions died at a mean of 4.3 mts after diagnosis. The common cause of death was pulmonary metastasis.

Discussion: Many so called frozen shoulders are joints inhibited by pain rather than by true contracture. The commonest lesion to mimic a frozen shoulder is a slow growing low/middle grade chondrosarcoma. Young patients presenting with persistent pain or night pain must be examined for this possibility. Consideration should be given for further investigation before instituting treatment. Delay in diagnosis adversely affects survival. Surgeons are reminded that although rare, a tumor should be suspected when clinical presentations are unusual.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 297 - 297
1 May 2006
Pillai A Shenoy R Ried R Tansey P
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Introduction Ewing’s sarcoma family of tumors was first described by James Ewing in 1921. It is a rare tumor and no one center can hope to accrue sufficient numbers over a reasonable period of time to accurately review them.

Objectives A retrospective analysis of all Ewing’s sarcomas of the upper limb from the Scottish Bone Tumor registry (1940–2000), is presented. Attempts have been made to elaborate on prognostic factors, and to document improvements in survival with trends in local therapy over the study period.

Results The registry included 23 patients with Ewing’s sarcoma of the upper limb bones. Age at diagnosis ranged from 7–58 Yrs (mean −21.6 Yrs). 48% of lesions occurred in the second decade and 26 % in the third decade. Male: Female ratio was 2.8: 1. The commonest site involved was the proximal humerus (30%), followed by scapula (21%), radius (17%) and hand bones (13%).Resectable lesions underwent excision and adjuvant radio/chemo therapy. Cumulative 5 year survival for the series was 52%. Forearm and hand lesions which achieved complete excision had best results (75% five year survival). Proximal humeral lesions had 57 % survival. Scapular lesions had the worst prognosis (20% survival). Death was usually due to metastatic disease (diagnosed mean 12mts after initial presentation). Lesions presenting with pathological fractures, or having metastasis at diagnosis had extremely poor survival. There was an increasing use of surgery, and changes to chemotherapy (Euro-Ewing protocol) during the latter part of the study period. There were no toxic deaths reported.

Discussion Ewing’s sarcoma is a rare lesion. Any of the upper limb bones can be involved. Majority of lesions occur within the first 3 decades of life (87%). Survival is highly dependent on initial presentation. The key prognostic factor is the presence of detectable metastasis at diagnosis. Increased use of surgery and newer chemotherapeutic agents have decreased the local relapse rate over the period of study.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 297 - 297
1 May 2006
Shenoy R Pillai A Ried R Tansey P
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Background Osteosarcoma is the most common bone sarcoma, and the 3rd most common malignancy in children and adolescents. It accounts for 20% of primary malignant bone tumors.

Methods A retrospective review of osteosarcomas from the Scottish National Bone Tumor Registry (1940–2000) involving the upperlimb bones is presented. Patient demography, type and location of lesions, treatment options, recurrence and survival rates, and metastasis have been analysed.

Results 75 cases were identified from the registry. Sex incidence showed a slight male preponderance with male: female ratio 1.14: 1.Age at presentation ranged from 4–88 Yrs (mean 28.44 Yrs). 46.7% sarcomas occurred in the second decade (11–20 Yrs). The humerus was the bone most frequently involved (78.6% of lesions), and the proximal humerus the commonest site (60%). The scapula was involved in 9.3% and the forearm in 8%.A rare solitary lesion of the clavicle was encountered.17% presented with pathological fractures at diagnosis. Patients typically present with dull aching pain of weeks to months. All patients underwent radiological studies and diagnostic biopsy. Treatment modalities included amputation, limb-sparing surgery, adjuvant/neoadjuvant chemotherapy and radiotherapy. The cumulative 5 year survival for the series was 32%.Death was usually due to pulmonary and skeletal metastasis, and the mean survival in such patients was 21.5 mts. Patients presenting with metastatic pulmonary disease had poor prognosis. Limb-sparing surgery with wide margins does not compromise survival. Results with custom endoprosthesis are encouraging.

Discussion Osteosarcomas require a multidisciplinary approach to diagnosis and treatment to optimise survival. During the first half of the study period amputation was the mainstay of treatment with high incidence of mortality due to metastatic disease. Recent advances in neoadjuvant/adjuvant chemotherapy have improved the ability to perform limb –sparing resections, and disease free and overall survival rates have improved. Regular, long follow-up is indicated in these patients.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 297 - 298
1 May 2006
Shenoy R Pillai A Ried R Tansey P
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Background: Tumors and tumor-like lesions of the clavicle are uncommon and often present with a diagnostic problem. Although almost every type of tumor has been reported from this location the true incidence of primary tumors is 0.5–1%.

Materials and Methods: A retrospective review of the Scottish Bone Tumor Registry (1940–2000). All histologically confirmed lesions with minimum 5 year follow-up are included.

Results: 32 lesions were identified from the registry. The age at presentation varied from 4 years to 84 years. There were 7 myelomas, 10 lymphomas, 2 Ewing sarcomas,1 osteosarcoma, 1 chondrosarcoma, 1 Giant Cell tumor, 1 Aneurismal bone cyst, 1 chondroma, 1 unicameral bone cysts, 1 non-ossifying fibroma, and 6 eosinophilic granulomas. 3 cases presented with pathological fractures. Majority lesions involved the medial third. Malignant lesion underwent excision and adjuvant chemo-radiotherapy. The cumulative 5 year survival was 80% when adequate surgical margins were achieved. Death was usually due to soft tissue and skeletal metastasis. Benign lesions were treated with curettage and bone grafting or by partial excision of the clavicle. 3 cases of eosinophilic granulomas and the solitary chondroma required no further treatment after biopsy.

Discussion: Metastatic tumors are more common than primary tumors in this region. Among primary lesions, malignant tumors are more common than benign. All ages can be affected. The subcutaneous location of the clavicle usually aids in early diagnosis. Anatomically, the medial third was the commonest site involved. Prognosis is good if adequate surgical margins can be achieved and if there is no distal spread. Partial or total claviclectomy usually results in good functional outcomes.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 298 - 298
1 May 2006
Shenoy R Pillai A Ried R Tansey P
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Background: Chondrosarcoma is the second most frequent primary malignant tumor of bone. The biologic evolution of these tumors is slow, requiring long follow up for meaningful survival analysis.

Methods: The clinicopathologic profiles of 84 (41 male, 45 female/M: F, 1:1.09) chondrosarcomas of the upper limb from the Scottish Bone Tumor Registry (1940–2000) are presented.

Results: The mean age at presentation was 54.8Yrs (range 12–85yrs).The proximal humerus was the most frequent anatomical site (30.2%).21% lesions involved the scapula, and 34% small bones of the hand. Local pain was the most frequently reported initial symptom. All patients were followed up for a minimum 60 mts. Radiographically; chondrosarcomas had a characteristic appearance of bone expansion and cortical thickening. The cumulative 5 year survival was 82.5%. Local recurrence developed in19.7 % (mean 40 mts after initial presentation), and distal metastasis in 16.2%.Hand tumors rarely had metastasis. Tumor breach at time of surgery increased risk of local recurrence. Histological grade was an important factor in predictor of local recurrence and metastasis.

Discussion: Chondrosarcomas are highly diverse tumors ranging from slow growing non- metastasizing lesions to highly aggressive metastasizing sarcomas. With adequate initial surgical intervention, chondrosarcoma is primarily a local disease with a low metastatic rate. Hand lesions have best prognosis.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 298 - 298
1 May 2006
Pillai A Shenoy R Ried R Tansey P
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Introduction: Types of cancer occurring in children are very different from those occurring in adults. Reliable data on incidence and mortality of childhood cancers is sparse.

Methods: A review of all primary malignant bone tumors in children (0–14 Yrs) from the Scottish National Bone Tumor Registry (1940–2000) is presented. Epidemiology, clinical presentation, pathology, radiological characteristics, treatment options, recurrence rates, geographic distribution and incidence are discussed.

Results: Excluding myelomas and lymphomas, 154 patients were identified. 122 (80.2%) lesions were benign, and 30 (19.7%) malignant. There were 20 osteosarcomas (66%), 8 Ewing’s sarcomas (26%), 1 chondrosarcoma and 1 fibrosarcoma.

Osteosarcoma – Age at presentation ranged from 4–14 Yrs (mean 10.3Yrs). 70 % involved 10–14 Yrs. Male: Female incidence was 1.5:1. 75% of lesions involved the proximal humerus.15 % presented with pathological fractures. The mean cumulative 5 year survival was 20%. Death was usually due to pulmonary metastasis.65% had pulmonary metastasis at a mean 6.3 mts after diagnosis. Mean survival in these patients was 14mts. Survival was superior with adjuvant chemotherapy and wide excision.

Ewing’s Sarcomas- Age at presentation ranged from 7–14 (mean 11.2Yrs).71.4% involved 10–14Yrs. Male: Female was 1.6:1. 62.5% lesions involved the humerus and 25 % the radius and 12.5% the scapula. The mean cumulative 5 year survival was 37.5%.Death was due to pulmonary or skeletal metastasis (mean 21.5mts). All patients had radiotherapy and chemotherapy.

Chondrosarcoma- A rare low-grade chondrosarcoma of the proximal humerus was encountered. Excision and grafting yielded good results.

Discussion: Majority of bone lesions in this age group are benign. Osteosarcomas and Ewing’s sarcomas predominate among the malignant (93%).The peak incidence occurs with adolescent growth spurt. Mean age is lower for osteosarcomas, and the sex incidence for both show male preponderance. Survival rates for Ewing’s was higher than for osteosarcomas. Pulmonary involvement at presentation had worst prognosis.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 290 - 290
1 May 2006
Pillai A Shenoy R Ried R Tansey P
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Background: The late effect of ionizing radiation on the development of sarcomas within the field of radiation is referred to as Post Irradiation Sarcoma (PRS).

Methods: A retrospective study from the Scottish Bone Tumor Registry (1940–2000) of PRS of the upper limb. The diagnostic criterion of Cahan was strictly followed and all patients followed up for 5 years.

Results: 11 female patients with previous history of radiotherapy (XRT) for carcinoma breast were identified as having PRS. The mean age at diagnosis was 68.7 years (51–80y). The latent period between irradiation and diagnosis ranged from 8 to 36 years (mean 15.6 y). All lesions occurred on the same side as breast malignancy. 6 lesions involved the proximal humerus and 5 the scapula. Histologically there were 7 osteosarcomas (65%), 1 chondrosarcoma, 1 spindlecell sarcoma and 2 dedifferentiated sarcomas. 2 humeral lesions underwent forequarter amputation, 2 excisions and endoprosthesis and 2 chemotherapy. Cumulative 5 year survival for humeral lesions was 33%. Survival was better with patients who achieved complete surgical margins. Majority of scapular lesions presented with either pulmonary/chest wall secondaries and were unresectable. Cumulative survival was poor ranging from 1 to 12 months (mean 6.2 months). De-differentiated lesions had the worst prognosis. Both orthovoltage and megavoltage XRT were implicated. It was not possible to analyze the relationship between total irradiation dose, individual fraction dose and incidence of PRS.

Discussion: PRS is an uncommon tumor with an incidence less than 1%, for patients who survive 5 years after XRT. Delay in diagnosis, aggressive nature, truncal location making extirpative surgery difficult and elderly patients all make the prognosis worse than that of primary sarcomas. As treatment of carcinoma of the breast evolves towards greater breast conservation it will be important to monitor the frequency of this complication more closely.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 297 - 297
1 May 2006
Pillai A Shenoy R Ried R Tansey P
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Background: Bizarre parosteal osteochondromatous proliferation [Nora’s lesion] is a rare tumourous lesion with aggressive growth that affects primarily the small tubular bones of extremities and often recurs after excision. It is often confused with chondrosarcomas, parosteal osteosarcomas and florid reactive periostitis.

Materials and Methods: The clinical and pathological findings in eight cases of Nora’s lesion from the Scottish bone tumour registry are presented.

Results: There were eight lesions reported in the registry. (5 female & 3 male). Anatomically there was 1 metacarpal lesion, 2 proximal phalanx lesions, 3 middle phalanx lesions and 2 distal phalanx lesions. Age at presentation ranged from 25 – 65 years (mean 41y). The common mode of presentation was pain and swelling for a period of 6 months to 2 years. There was no history of trauma. Two patients were initially misdiagnosed, one as synovial chondromatosis and the other as an osteochondroma. Treatment was in the form of an excision biopsy. The recurrence rate after excision was 62.5%. 60 % of recurrences occurred within 12 mts of excision. One phalangeal lesion recurred twice after excision. There was no distal metastasis.

Discussion: Bizarre parosteal osteochondromatous proliferation is histologically composed of bony, chondroid and fibrous proliferation, with a high cellular density and bizarre chondrocytes but is devoid of cellular atypia or necrosis. It is a rare pseudotumorous lesion, with typical clinical, radiographic and histopathology findings similar to those of other benign and malignant tumours. The rarity of this lesion and the high local recurrence rate necessitate an accurate histological diagnosis and complete excision.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 298 - 298
1 May 2006
Shenoy R Pillai A Ried R Tansey P
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Introduction: Musculoskeletal tumours and lesions resembling tumours present exceptionally difficult diagnostic and treatment problems in children. Presenting symptoms are usually a poor guide to diagnosis, and are often misleading.

Methods: A review of benign bone lesions of the upper limb in the peadiatric age group (0–14 yrs) from the Scottish Bone Tumour Registry is presented.

Results: Excluding myelomas and lymphomas, the registry included 154 lesions. 122 (80.2%) were benign including, 25 unicameral bone cysts, 22 aneurysmal bone cysts, 31 chondromas, 15 osteochondromas, 12 diaphyseal aclasis, 7 osteoidosteomas, 2 chondroblastomas, 2 nonossifying fibromas, and 1 each of giant cell tumour, eosinophilic granuloma and chondromyxoid fibroma.

Unicameral cysts- Age at presentation ranged from 3–14 yrs (mean 9.4).Male: Female incidence was 7.3:1. 92% involved the proximal humerus. 88 % presented with fracture. Recurrence rate after curettage was 20% at a mean of 10.8 mts.

Aneurysmal cysts – Age at presentation ranged from 5–14 yrs (mean 9.3). 55% involved the proximal humerus, and 20% hand bones. 45% presented with fracture. Recurrance rate after curettage was 31.8% at a mean of 15.1mts.

Chondromas- Age at presentation ranged from 3–14 yrs (mean 10.4).20 lesions were solitary and 11 multiple. Among solitary lesions, 16 were central (75% hand) and 4 parosteal.

Osteochondromas- Age at presentation ranged from 1–14 yrs (mean 10.1).Male: female ratio was 2.75:1. 53.3% involved the proximal humerus.

Osteoid Osteoma- Age at presentation ranged from 5–13 yrs (mean 10.14). Male: female ratio was 1:6. 42% involved the hand.

Discussion: Benign tumours compose majority of bone neoplasms in this age group. Unicameral and aneurysmal cysts, along with enchondromas were most frequent. Although the age at presentation shows variations with tumour type, the incidence seems to peak at 9–10 Yrs. Careful analysis of the clinical presentation, radiological characteristics and histology are required to distinguish them from malignant lesions.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 297 - 297
1 May 2006
Pillai A Shenoy R Ried R Tansey P
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Background: Osteoid Osteomas were first described by Bergstrand (1930), and were later elaborated by Jaffe (1935). They account for 12% of all benign bone tumors. Approximately 6–8% of lesions occur in the hand, and can be extremely difficult to diagnose.

Aims: A retrospective review of osteoid osteomas from the Scottish Bone Tumor Registry is presented focusing on the unusual clinical features of lesions of the carpus and hand.

Results: 19 patients (8 male, 11 female) were identified from the registry. The mean age at presentation was 27.5 Yrs (10–56 Yrs). 78% of lesions occurred within 2nd–3rd decade of life. Pain over the involved area most noticeably at night, was the usual presentation. 21% gave history of associated trauma. Phalangeal lesions accounted for 68.4% tumors with the proximal phalanx predominating.4 lesions involved the distal phalanx. There were 3 metacarpal and 3 carpal lesions. Carpal bones involved included the Capitate (2), and the Trapezium (1). Clubbing was noticed in distal phalanx lesions. The mean time from presentation to diagnosis was 5.6 months. 9 patients were initially misdiagnosed as having either a traumatic or infective condition.3 patients required a bone scan for diagnosis. All patients underwent surgical excision, with 2 requiring bone grafting. Follow up ranged from 1–9 Yrs (mean 3Yrs). There were no instances of recurrence or spontaneous regression.

Discussion: Osteoid Osteoma is an infrequent tumor of the hand. Absence of typical pain pattern, unobtrusive radiographic features (absence of reactive bone, inapparent nidus), and variations in the histological picture make diagnosis in this region difficult. Lesions are easily misdiagnosed and successful treatment often delayed. Isotope bone scan is diagnostic and CT accurately visualizes the nidus. Awareness of these characteristics may aid early diagnosis. Surgical excision is usually curative and has excellent prognosis.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 79 - 79
1 Mar 2006
Pillai A Basapa P Hilmy O El-Hadidi M
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Background: Metal on metal resurfacing of the hip is an attractive conservative treatment option for the younger, active arthritic patient. It has the advantages of bone preservation and the longevity of metal bearing surfaces. Concerns remain over the performance of these implants due to historical failure of similar devices. The possible longer-term survival of these implants can only be justified if the early results are as successful as conventional hip replacement.

Patients & Methods: The clinical and radiological follow-up of our first 25 consecutive resurfacing patients is presented. The Birmingham Hip Resurfacing prosthesis (Midland Medical Technologies, Birmingham, UK) was used, and all procedures performed by the senior author (EHM). Clinical assessment was done using the modified Harris Hip Score, and functional outcomes measured using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC). Radiographs were examined for radioleucent lines, migration of components, osteolysis and heterotropic ossification.

Results: 28 primary hip resurfacings in 25 patients were reviewed. The mean follow up period was 18 mts (12– 36mts). The mean age of patients at time of operation was 51yrs (37–64 yrs). Main indication for surgery was Osteoarthrosis. The mean Harris Hip Score improved from 44 preoperative, to 94.5 postoperative. The mean preoperative WOMAC score was 30 and the mean postoperative score 88.The average duration of hospital stay was 5 days, and the average operative blood loss 3g %. All patients in paid employment returned to work at an average of 8 weeks postoperatively, and majority of patients are able to participate in sports and recreational activities. There were no cases of dislocations, femoral neck fractures, avascular necrosis or osteolysis.

Conclusion: Hip resurfacing using metal on metal hybrid fixed components, offers a viable treatment alternative in younger active patients. Early outcomes are at least comparable to total hip replacement in terms of pain relief and restoration of function.

Despite the lack of long-term data, the relative absence of complications and the potential benefits justify its continued use. We believe the future is very promising for this procedure.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 53 - 53
1 Mar 2006
Pillai A Sween M Wishaw W
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Background: Total Hip Replacements in younger active patients continues to pose a major challenge. Surface replacement techniques, designed to preserve bone stock do not yet have proven long term results. Early cemented designs in this population had high failure rates. Concept of fixation of total hip prosthesis by bony in-growth rather than by cement is an attempt to decrease the incidence of loosening. Ceramic joint surfaces produce minimal wear debris.

Objectives: A medium term follow-up of clinical and radiological results of the JRI Furlong hydroxyapatite coated prosthesis with ceramic bearing surfaces in young active patients.

Methods: A retrospective analysis of 43 JRI Furlong Hip Replacements (mean age 32 Yrs) in 33 patients is presented. The minimum follow-up was 60 months. Functional assessment was done using the Harris Hip Score. Radiolucency around the femoral stem according to Gruen (zone 1-7) and the acetabulum as described by Charnly and De Lee (zone 1–3) is documented. A fully coated femoral component along with the press –fit HA coated CSF cup with a 28mm ceramic insert was used. All cups were routinely augmented with screws.

Results: The mean Harris Hip score was 90 (46–96). 4 patients had a score less than 80. 84.2% were completely pain free. Acetabular radioleucencies were noted in 32 hips (72 %).28 cups had radiolucent lines (RLL) in zone 2, 2 cups in zone 1 and 1 cup in zone 3. In 10 patients (23%) the lucent area measured > 2mm at the cup bone interface. No hips had RLL in more than two zones. 4 stems had RLL > 2 mm involving the Gruen zone 7. 90 % showed a distinct osteoblastic reaction at the tip of the femoral component. There was no calcar resorption, endosteal cavitation or ectopic ossification. There were no instances of ceramic fractures and no hips were revised.

Discussion: The JRI Furlong hip gives good functional results in young patients in the medium term. Although of concern, there was no co-relation between the presence of acetabular RLL and functional outcome. The RLLs were not thought to be progressive. The RLLs can be explained by backside wear or by fretting of the screws by the ceramic liner. Long term follow up of the CSF cup will be required to determine if these radio-lucent lines are an early sign of failure at the interface or whether they simply represent stable in- growth of fibrous tissue in this highly stressed region.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 41 - 42
1 Mar 2006
Shenoy R Hegde G Young E Pillai A
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Background The clinical standards board in Scotland has recognized hip fractures as the most common injury in older people. Hip fracture care is now emerging as a case study for clinical governance in Scotland. Aims/Methods The results of a prospective audit of 1177 hip fractures admitted to Wishaw General Hospital over a 36 month period are presented. All aspects of care from admission to discharge are analyzed, and patients followed up for 4 months after discharge. Results Pre Fracture The most common age group of patients was 80–90 Yrs (40.9%). 10 % of patients were over 90 Yrs.80.3% were female. There was no significant difference in side involved (L 53.3%: R 46.7%).60.1% patients were admitted from own home.71 patients (6%) originated from other wards within the hospital.39.6% patients were found to be living alone. Only 25.9% patients walked alone out of doors before fracture, while 39.1% walked alone indoors but not out of doors.43.8% could walk with out aids. Surgery 52.9% underwent osteosynthesis with screws and plate.34.2% had hemiarthroplasty.3.4% had total hip replacement. 4.1% was treated conservatively.48.3% had general anaesthetic and 47.4% regional anaesthetic.93 % received thromboembolic prophylaxis, and 96% antibiotic prophylaxis. The post operative wound infection rate was 3.2%. 4.9% required a second surgical procedure within 4 months. These included 14 patients who had dislocated prosthesis reduction, 14 conversions to total hip replacement, 9 conversions of osteosynthesis to hemiarthroplasty and 5 refixations. Post Fracture (4 Months) 41.9 % returned to their own home, while 14.7 went into nursing homes.11% were able to walk out of doors alone, and 28% could walk in doors alone. Only 7% could mobilize without and aids, 19.2% used one aid and 30.2% required a walking frame.41.6 % had no hip pain, 18.2 % complained of slight or intermittent discomfort.

Conclusions Older patients (80 Yrs +) are at significant risk of sustaining hip fractures. The risks are greater in patients living alone and in females. Patients with significant co morbidity may have to be treated conservatively. There is a considerable risk of requiring a second surgery. Only about 69 % of patients living in their own homes are able to do the same after fracture. Only about 50 % of previously independent patients were able to regain the same level of mobility.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 11 | Pages 1531 - 1535
1 Nov 2005
Pillai A Atiya S Costigan PS

We have investigated the annual incidence of Perthes’ disease in Dumfries and Galloway (Southwest Scotland), in relation to the population density and socio-economic status. The incidence of Perthes’ disease in rural Scotland is comparable with that in urban areas (15.4 per 100 000). There was a direct association between the incidence of Perthes’ disease and deprivation scores, with the highest incidence in the most deprived areas. A higher incidence of Perthes’ disease was noted in areas with a lower population density compared with those with a higher density. We found no correlation between population density and deprivation scores for individual electoral wards within the region.