For patients where curative surgery was an option, primary wide local excision (15 patients) or primary amputation (2 patients) was performed. The remaining 2 patients presented with unresectable disease due to the location and localised spread; an embolisation was performed for palliation in both cases. Revision surgery was needed in 9 patients for either a positive resection margin confirmed by histology, or a recurrence; these included 3 secondary amputations. A histologically proven recurrence occurred in 6 patients after an average of 15.8 (4 to 41) months. Local adjuvant radiotherapy was administered to 7 patients and a combination of radio–and chemotherapy was used in 2 patients for metastases. Mortality was 53% (9 patients) by the end of 36 months follow-up period.
Presented with anterior knee pain. Examination revealed supra-patellar fullness and tenderness. MRI scan showed a suspicious soft tissue tumour. Histology confirmed PVNS after excision biopsy. Presented with medial knee pain, most pronounced after exercise. McMurray test was positive for a meniscal tear. MRI confirmed meniscal tear and additional localised PVNS. The patient underwent repair of the meniscal injury but continued to complain of pain. Following excision of PVNS there was marked improvement in the patients’ symptoms. Presented as massive soft tissue swelling of the right knee. Past medical history included a diagnosis of tuberculosis and fibrosarcoma on the knee. She was referred to our centre following two diagnoses, three surgeries and a supracondylar femoral fracture. The patient was previously advised an above knee amputation which she refused. A repeat biopsy with immunohistochemistry studies at our unit confirmed the diagnosis of a PVNS. Patient is awaiting a total knee replacement with subtotal synovectomy. Presented with swollen right knee, pain and restriction of movement. MRI scan suggested a diagnosis of PVNS. The patient underwent subtotal synovectomy and histology confirmed this to be PVNS. Subsequently the patient had two recurrences, the first at 2 years and later at 4 years from initial surgery. Repeat MRI scan showed extensive third recurrence. The patient is awaiting a further open synovectomy, followed by low dose radiotherapy.
As a result of the increased popularity of metal-on-metal bearings for total hip arthroplasty, concerns have been expressed about patient exposure to increased serum metal ion levels. We therefore performed a retrospective review of patients with metal-on-metal, uncemented Ring total hip replacements with a minimum follow up of thirty years. After allowing for prosthesis revision and patient mortality, 6 hips in 5 patients were reviewed and serum ion levels measured. Similar cohorts of patients with other combinations of bearings were compared with an age-matched osteoarthritic control group. Serum cobalt and chromium levels in the metal-on-metal hip arthroplasty group were significantly higher than in all other groups and approximately five and three times greater respectively than in the group with no implants. Unlike the stainless steel-on-plastic group, the cobalt/chrome-on-plastic group showed significantly raised serum cobalt levels compared with the control group. It is of interest that patients who have had their metal-on-metal hip replacements revised to metal-on-plastic, have metal ion levels that are not statistically different to those of the osteoarthritic control group. Though we acknowledge the small numbers of patients studied, no identifiable harmful effects were found. We conclude that serum metal ions remain elevated throughout the life of the metal-on-metal articulation. Metal bearing hip arthroplasty is being used in ever younger patients and together with increased life expectancy we are exposing our patients to potentially harmful levels of metal ions throughout the life of the implant.
We examined the position of the superior gluteal nerve in forty-four cadaveric hips in relation to the greater trochanter and the acetabulum . We found that the nerve lay a mean of 4.8 centimetres from the greater trochanter with a range of two to nine centimetres and a mean of 3.2 centimetres from the acetabulum. The nerve was visibly damaged in three out of forty-four hips following direct lateral approach. Our study does not support the “safe zone” proximal to the greater trochanter and suggests the proximity of the nerve to the acetabulum as a potential cause of nerve injury. Abductor weakness following the direct lateral approach to the hip is well described and is associated with damage to the superior gluteal nerve on neurophysiological testing in from 23–26 %. A “safe zone” has been described of up to five centimeters proximal to the greater trochanter. We examined forty-four cadaveric hips exposed by the direct lateral approach by surgeons not directly involved with the study. We measured the position of the superior gluteal nerve in relation to the greater trochanter, the acetabulum and the margin of the skin incision. We examined the nerve for visible signs of damage. We found the position of the superior gluteal nerve to be a mean of 4.8 centimeters from the greater trochanter (range two to nine), 3.2 centimeters from the superior margin of the acetabulum (range one to eight), and 4.1 centimeters from the margin of the skin incision. There was visible damage to the nerve in three of forty-four cases. Neurophysiological studies show subclinical damage to the superior gluteal nerve in up to 77% of cases following direct lateral approach to the hip and in association with abductor weakness in 23–26%. Our study does not support the notion of a “safe zone” of five centimetres proximal to the greater trochanter, and with a mean of 4.8 centimetres the zone is unsafe more often than it is safe. The proximity of the superior gluteal nerve to the superior margin of the acetabulum suggests that it may be damaged by retractor placement at this site.
Metal-on-metal bearings for total hip replacement (THR) are becoming increasingly popular. Improved wear characteristics mean that these articulations are being inserted into younger patients in the form of THR and resurfacing procedures. This has led to concerns regarding potential carcinogenicity because of the increased exposure to metal ions that the procedure brings. We have studied the serum cobalt and chromium concentrations in patients who had primary, well-fixed Ring metal-on-metal THRs for more than 30 years. The levels of cobalt and chromium were elevated by five and three times, respectively compared with those in our reference groups. Metal-on-metal articulations appear to be the source of metal ions throughout the life of the prosthesis. In three patients who had undergone revision of a previous metal-on-metal THR to a metal-on-polyethylene replacement the levels of metal ions were within the normal range. The elevations of cobalt and chromium ions seen in our study were comparable with those in patients with modern metal-on-metal THRs.
Subluxation of the hip is common in patients with intermediate spinal muscular atrophy. This retrospective study aimed to investigate the influence of surgery on pain and function, as well as the natural history of subluxed hips which were treated conservatively. Thirty patients were assessed clinically and radiologically. Of the nine who underwent surgery only one reported satisfaction and four had recurrent subluxation. Of the 21 patients who had no surgery, 18 had subluxation at the latest follow-up, but only one reported pain in the hip. We conclude that surgery for subluxation of the hip in these patients is not justified.
Soft tissue tumours on the sole of the foot are rare and difficult to diagnose, we report a series of five patients who presented with a late diagnosis of a soft tissue tumour on the soles of their feet. We reviewed the notes of five patients who presented with lesions on the soles of their feet. There were 3 males and two females with an age range from 35yrs to 78 yrs. Our results showed that there was at least a one year delay in their diagnosis from their initial symptoms. They all sought medical treatment late, and were all originally diagnosed with benign lesions at their first presentation. All but one, were found to have malignant lesions on biopsy which required surgical excision. As a consequence of the delay in their presentation and diagnosis, there was also a delay in their treatment. Our conclusions are that tumours on the soles of the feet are difficult to diagnose and almost invariably present late.