To make an inoculum for induction of Implant-Associated Osteomyelitis (IAO) in pigs based on bacterial aggregates resembling those found on the human skin, i.e. aggregates of 5–15 µm with low metabolic activity. The aggregates were evaluated and compared to a standard planktonic bacterial inoculum. The porcine Aim
Method
The primary aim of this study was to examine whether the use of iodine impregnated incision drape (IIID) decreased the risk of periprosthetic joint infections (PJIs). The secondary aim was to investigate whether intraoperative contamination could predict postoperative infection. PJI is a devastating incident for the patients and in a population that is getting older and the incidence of arthroplasty surgery is rising it is vital to keep the infection rate as low as possible. Despite prophylactic measures as pre-operative decontamination, antisepsis and prophylactic antibiotics the infection rate has been constant at 1–2%. We performed a transregional, prospective, randomized two arm study (IIID vs control group) of 1187 patients undergoing primary knee arthroplasty surgery. A database with patient demographics and surgical observations was established with the purpose of following the patients for ten years. Patients, who developed an infection within the first year of surgery were analyzed for correlation with the intraoperative bacterial findings and the use of IIID.Aim
Method
The Oxford hip score (OHS) is a 12-item questionnaire designed
and developed to assess function and pain from the perspective of
patients who are undergoing total hip replacement (THR). The OHS
has been shown to be consistent, reliable, valid and sensitive to
clinical change following THR. It has been translated into different
languages, but no adequately translated, adapted and validated Danish
language version exists. The OHS was translated and cross-culturally adapted into Danish
from the original English version, using methods based on best-practice
guidelines. The translation was tested for psychometric quality
in patients drawn from a cohort from the Danish Hip Arthroplasty
Register (DHR).Objectives
Methods
Osteoarthrosis (OA) stands alongside cancer and heart disease as one of the major causes of suffering and disability amongst the elderly. Changes related to OA occur in all elements of the joint, and there are indications that sub-chondral cancellous bone plays a primary role in the cartilage degeneration in OA. Most previous investigations have been focused on moderate and late OA, whereas little is known about the changes in cancellous bone microstructure in human early OA. This study quantified cancellous bone microstructure in early-stage OA using three-dimensional (3D) methods. Subchondral cancellous bone specimens, produced from 10 human post-mortem early-stage osteoarthrotic (OA) proximal tibiae and 10 normal age- and gender-matched proximal tibiae, were allocated to 4 groups: medial OA, lateral control, normal medial control, and normal lateral control. OA initiates mostly at the medial condyle, and histological analysis was done to confirm this change. The cylindrical specimens were micro-computed tomography (micro-CT) scanned. From accurate 3D data sets, structural parameters were determined by means of true, unbiased and assumption-free 3D methods. The data were assessed statistically, and a p<
0.05 was considered significant. Our data supported the hypothesis that significant microstructural changes – other than density changes – occur in early-stage OA cancellous bone. OA cancellous bone is markedly plate-like, less anisotropic, less interconnected, but lower in mechanical properties which suggests a disorganisation in the microstructure as OA initiation. Structure model type best explains the mechanical properties for the OA and the normal controls. However, the determination coefficients (R2) for the OA group are largely reduced. These results indicate significant property and quality deterioration in early-stage OA subchondral cancellous bone.
