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Bone & Joint Open
Vol. 4, Issue 2 | Pages 87 - 95
10 Feb 2023
Deshmukh SR Kirkham JJ Karantana A

Aims

The aim of this study was to develop a core outcome set of what to measure in all future clinical research on hand fractures and joint injuries in adults.

Methods

Phase 1 consisted of steps to identify potential outcome domains through systematic review of published studies, and exploration of the patient perspective through qualitative research, consisting of 25 semi-structured interviews and five focus groups. Phase 2 involved key stakeholder groups (patients, hand surgeons, and hand therapists) prioritizing the outcome domains via a three-round international Delphi survey, with a final consensus meeting to agree the final core outcome set.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_2 | Pages 92 - 92
1 Mar 2021
Taha R Davis T Montgomery A Karantana A
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Abstract

Objectives

1. To describe the epidemiology of metacarpal shaft fractures (MSF) in adults. 2. To evaluate the variation in practice and document complications following usual care. 3. To explore factors associated with treatment modality. 4. To document hospital resource use following MSF.

Methods

A multi-centre, retrospective, cross-sectional study of MSF at six centres. The healthcare records, operative notes and imaging of adults presenting within 10 days of a MSF, affecting the second to fifth metacarpal between 1st August 2016 to 31st July 2017, were reviewed. Total number of Emergency Department (ED) attendances were used to calculate prevalence. Data analyses are primarily descriptive with 95% confidence intervals to quantify uncertainty in estimates.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 314 - 314
1 Jul 2011
Karantana A Boulton C Shu KSS Moran C
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Methods: We examined prospectively collected data from 6782 consecutive hip fractures to identify 327 fractures in female patients aged 65 years and younger. We report on demographic characteristics, treatment and outcome. We compare this group with a cohort of 4810 consecutive hip fractures in older females.

Results: Not surprisingly, younger women had higher levels of mobility and independence than their older counterparts. However, over 20% mobilised with aids, needed help with activities of daily living and/or had significant co-morbidity. A significantly higher proportion of younger patients were smokers. This had a strong influence on the relative risk of “early” as opposed to “late” fracture (Hazard Ratio 4.7, p< 0.01). Mortality was 0.7% at 30 days and 4.2% at one year.

We calculated age-related incidence of hip fracture in the local population and noted the first significant increase at the interval between 40–44 and 45–49, rather than the age of 50, which is when the onset of screening of hip fracture patients for osteoporosis occurs in most health areas. Lag screw fixation was the most common method of operative fixation. General complication rates were low, as were reoperation rates for cemented prostheses. Intracapsular fractures are an interesting subgroup. When displaced, 39% (61/158) had lag screw fixation and 61% (97/158) were treated by arthroplasty. Kaplan-Meier implant survivorship of displaced intra-capsular fractures treated by reduction and lag screw fixation was 82% at two and 71% at five years.

Conclusion: Hip fractures in females to 65 years of age are sustained by a population at risk as a result of patho-physiology. Treatment in this age group, particularly of intracapsular fractures, remains a topic of debate. Understanding the characteristics of these patients, may lead to an improved opportunity, if not for prevention, at least for intervention.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 24 - 24
1 Jan 2011
Karantana A Suri M Howell C Pace A Dhar S
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This is a case series of 25 patients with Multiple Epiphyseal Dysplasia (MED), a genetically determined disorder characterised by abnormal ossification of multiple epiphyses. The Nottingham Skeletal Dysplasia Clinic has run since 1966. In 1994 it combined with the Clinical Genetics Service providing care to patients from throughout the region. We collected data on MED patients with follow up of 1 to 41 years (average 12 years) and described their presenting symptoms, genetic, clinical and radiographic features. We followed the natural history and vast array of treatments.

From the genetic point of view, 90% of patients counselled had typical AD-MED and 10% syndromic MED. Seven families opted to have testing. There were MATN3 mutations in 10% of the cohort, with marked intra-familial variability of phenotype. The average age at presentation was thirteen, with 80% of patients presenting before their sixteenth birthday. A third was seen because of a known family history of MED. Newly diagnosed index patients tended to present later. The most commonly affected joint at presentation was the hip and the most common knee deformity genu valgum. Symptoms progressed with time and joints not clinically affected at presentation became symptomatic later. Sixty percent of patients had further joint involvement within 10 years of diagnosis. Treatment ranged from orthotics to arthroplasty. Half of patients required surgical intervention at least once. Six patients underwent hip arthroplasty at an average age of 37.

MED is a rare diagnosis but has significant impact on the quality of life of those diagnosed, who require the support of a multidisciplinary team from an early age. This is not only to help manage symptoms and preserve function, but also to counsel on the progressive nature and the genetic aspects of the disorder.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 284 - 285
1 May 2010
Karantana A Hobson S Dhar S
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Introduction: Few intermediate term studies have presented data on modern total ankle replacement designs. This independent, prospective study provides clinical and radiographic results for 50 Scandinavian Total Ankle Replacements with at least 5 years follow up.

Methods: 50 consecutive STAR total ankle replacements were performed in 46 patients, aged 33–79 (mean 63) between 1999 and 2002 by a single surgeon. These were prospectively followed up on annually for a mean of 6 years (5–8 years).

Results: 34 replacements were performed for osteoarthritis, the remainder for inflammatory arthropathy. 13 ankles had a preoperative varus or valgus deformity of more than 10 degrees. There were 3 deaths, therefore 47 ankles reviewed.

5 revisions were performed; 2 for stiffness (1 tibial component, 1 insert), 2 for stress fractures (tibial component only) and 1 insert fracture. 3 of these cases required further surgery following their first revision (1 fusion for deep infection, 1 insert exchange for edge loading and one arthoscopic debridement plus calcaneal osteotomy for painful varus deformity).

There were no primary revisions for aseptic loosening or deep infection. 3 radiographs demonstrated non-progressive lucent lines behind the tibial component.

Further surgery was required in 8 other ankles (6 calcaneal osteotomies and 2 arthroscopic debridements). Complete correction of pre-operative deformity was ultimately achieved in all but 4 ankles.

The mean postoperative American Orthopaedic Foot and Ankle Society Score was 77.

Discussion: At a minimum follow up of 5 years after Scandinavian Total Ankle Replacement, all but one of our ankles have well functioning prostheses in situ. However, 13/47 ankles required further surgery of some kind, including 5 component revisions (90% survival).

Conclusion: Total ankle arthroplasty is a reliable procedure for ankle arthrosis at intermediate term follow up. It provides good functional results and symptomatic benefit, although additional operative procedures may be required.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 36 - 36
1 Mar 2006
Karantana A Downs-Wheeler M Pearce C Johnson A Bannister G
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The purpose of the study was to objectively compare the effects of the scaphoid and Colles’ type casts on hand function. Currently there is no such published study.

Both casts are commonly used to immobilise suspected and radiologically proven undisplaced scaphoid fractures. There is no difference in non-union rates. The scaphoid incorporates the thumb in palmar abduction, whereas the Colles’ type cast leaves the thumb free. Although necessary for bone healing, immobilisation disrupts function and may require intensive corrective physiotherapy. Unnecessary immobilisation of uninvolved joints should be avoided when use does not compromise fracture stability.

We compared the effect of the two casts on hand function in 20 healthy right hand dominant volunteers using the Jebsen-Taylor Hand Function Test, which uses seven subtests designed to test tasks representative of everyday functional activities. Data were obtained through a mixed between and within subject design.

Using the Jebsen-Taylor Hand Function Test, median overall scoring in the Colles’ type cast was 2.5 times that obtained in the scaphoid. In timing individual subtests, the analyses show significant differences (p< 0001) between the presence and absence of a cast. When comparing the two cast types, mean times for all subtests are less in the Colles’ than in the scaphoid, with the difference reaching statistical significance in five out of seven subtests.

Having either type of cast significantly impairs handling and finger dexterity, and so affects activities of daily living. A scaphoid, however, is much more limiting than a Colles’ type cast. This makes it clearly more inconvenient for the patient with socioeconomic implications and occasionally issues of compliance during a long period of immobilisation.