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Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 274 - 275
1 Jul 2011
Blake SM Gie GA Williams D Hubble M Timperley AJ
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Purpose: Removal of all foreign material is the normal practice at the time of revision arthroplasty for sepsis. However, removal of well-fixed bone cement is time consuming, can result in significant bone stock loss and increases the risk of femoral shaft perforation or fracture. We have performed two-stage revision for infection in a series of cases in which we have left oseeointegrated femoral cement at the first stage and we present the results of this technique.

Method: All patients underwent two-stage revision for infection. At the first stage the prostheses and acetabu-lar cement were removed but when the femoral cement mantle demonstrated good osseo-integration it was left in-situ. Following Girdlestone excision arthroplasty (GEA), patients received local antibiotics delivered by cement spacers, as well as systemic antibiotics. At the second stage the existing cement mantle was reamed, washed and dried and then a femoral component was cemented into the old mantle.

Results: Sixteen patients (M:F 5:11) had at least three years follow up (mean 80 months, range 43 to 91). One patient died of an unrelated cause at 53 months. Recurrence of infection was not suspected in this case. The mean time to first stage revision was 57 months (3 to 155). The mean time between first and second stages was 9 months (1 to 35). Organisms were identified in 14 (87.5%) cases (5 Staphylococcus Aureas, 4 Group B Streptococcus, 2 Coagulase negative Staphylococcus, 2 Enterococcus Faecalis, 1 Escheria Coli). At second stage, five (31.2%) acetabuli were uncemented and 11 (68.8%) were cemented. There were two complications; one patient dislocated 41 days post-operatively and a second patient required an acetabular revision at 44 days for sudden loss of fixation. No evidence of infection was found at re-revision. One patient has been revised for recurrent infection. Currently no patients are suspected of having a recurrence of infection.

Conclusion: Retention of a well-fixed femoral cement mantle during two-stage revision for infection and subsequent in-cement reconstruction is safe with a cure rate of 93%. Advantages include a shorter operating time, reduced loss of bone stock, improved component fixation and a technically easier second stage procedure.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 393 - 393
1 Jul 2010
Veitch SW Howell JR Hubble MJ Gie GA Timperley J
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The review of the first 325 Exeter Universal hips reported good long term survivorship despite the majority of cups being metal backed. We have reviewed the long term performance of the concentric all-polyethylene Exeter cups used with the Universal Exeter stem.

Clinical and radiographic outcomes of 263 consecutive primary hip arthroplasties in 242 patients with mean age 66 years (range, 18 to 89) were reviewed. 118 cases subsequently died none of whom underwent a revision. Eighteen hips have been revised; thirteen for aseptic cup loosening, three for recurrent dislocation and two for deep infection. Three patients (four hips) were lost to follow-up. The minimum follow-up of the remaining 123 hips was 10 years (mean 13.3 years, range 10–17). Radiographs demonstrated 6 (6%) of the remaining acetabular prostheses were loose. The Kaplan Meier survivorship at 14.5 years with endpoint revision for all causes is 91.5% (95% CI 86.6 to 96.2%). With endpoint revision for aseptic cup loosening, survivorship is 93.3% (CI 88.8 to 97.8%).

This series included a number of complex cases requiring bone blocks and/or chip autograft for acetabular deficiencies. The concentric all polythene Exeter cup and Exeter stem has excellent long term results particularly when factoring in the complexity of cases in this series.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 534 - 534
1 Aug 2008
Bailie AG Howell JR Hubble MJ Timperley AJ Gie GA
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Introduction: Recurrent dislocation can be a significant problem after total hip replacement. The use of a constrained tripolar liner is an option in the surgical treatment of dislocation or instability.

Methods: A retrospective review was carried out of patients identified from a prospective database. All patients had a constrained liner cemented onto a satisfactory pre-existing cement mantle, cemented into a reconstruction ring, or cemented into a well fixed cementless shell. The Osteonics Tripolar Liner was used in all cases; the outer aspect of the liner was prepared with a burr to create grooves and thus improve cement interlock. Data collected included demographics, reason for revision, re-revision rate, outcome and survival.

Results: There were 58 cases identified where a cemented constrained liner was inserted at revision hip surgery. Average age at time of surgery was 77years (range 40–94). There were 9 patients who died with less than 2 years follow-up; they were excluded, leaving a study group of 49 cases. No cases were lost to follow-up. Average duration of follow-up was 46months (range 24–76). There have been 4 infections, one of which required removal of prostheses and a 2-stage revision. There was one case of fall post-operatively and fracture of the contra-lateral femoral neck. There have been 4 implant failures requiring re-revision. All failures were due to disarticulation of the liner, 2 of which occurred in the same patient on separate occasions. There have been no revisions for loosening, and there have been no cases of failure at the bone-cement interface or at the cement-cement interface with the cement-in-cement technique. Overall survival of the cemented constrained liner was 90% at average 3.8years.

Conclusion: This study demonstrates that cementing a constrained liner into the acetabulum is a viable option in revision hip surgery, particularly in the management of instability.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 239 - 239
1 May 2006
Duncan WW Hubble MJW Timperley AJ Gie GA
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Retention of well fixed bone cement at the time of a revision THA is an attractive proposition, as its removal can be difficult, time consuming and may result in extensive bone stock loss or fracture. Previously reported poor results of cemented revision THA, however, have tended to discourage Surgeons from performing ‘cement in cement’ revisions, and this technique is not in widespread use.

Since 1989 in Exeter, we have performed a ‘cement within cement’ femoral stem revision on 354 occasions. An Exeter polished tapered stem has been cemented into the existing cement mantle on each occasion.

Clinical and radiological follow up of 5 years or longer is available for 156 cases. On no occasion has a cement in cement femoral stem had to be re-revised during this time for subsequent aseptic loosening.

This has encouraged the refinement of this technique, including the development of a new short stem designed specifically for cement within cement revisions. This stem is designed to fit into an existing well fixed cement mantle of most designs of cemented femoral components or hemi-arthroplasties, with only limited preparation of the proximal mantle required. The new stem greatly simplifies cement in cement revision and minimises the risk of distal shaft perforation or fracture, which is otherwise a potential hazard when reaming out distal cement to accommodate a longer prosthesis.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 43 - 43
1 Mar 2005
Rigby MC Kenny P Sharp R Timperley AJ Gie GA
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Acetabular component loosening and pelvic osteolysis continue to be a significant clinical challenge in revision hip arthroplasty. We present results of 339 cases of acetabular reconstruction with impacted allograft.

All patients who under went acetabular reconstruction with impaction allograft between July 1995 and July 1999 were included. Clinical and radiographic data was collected prospectively.

There were 339 patients identified. Average age was 71 years. The majority were first time revisions (201) but the group includes 2nd, 3rd and 4th revisions with 34 two-stage revisions and 44 primary arthroplasties.

There were multiple surgeons with 2/3 being consultants and 1/3 fellows. Pre and post-operative clinical assessment included Oxford and Harris hip scores, and a modified Charnley score for pain, function and range of movement.

Pre-operative radiographs were classified with the Paprosky classification. Follow up radiographs were assessed for graft thickness, component migration, graft reabsorption and lucent lines.

There were 10 grade I, 205 grade II, and 103 grade III defects with 3 pelvic discontinuities. Reconstruction methods included impaction only, rim and/or medial mesh, KP plate fixation and reinforcement cages.

Follow up average was 6.1 years (4.3 – 8.4) and no patient was lost. Infection was identified in 13 patients (5 recurrent 89% eradication and 8 new 2.6%). There were 6 nerve injuries, 2 remain unresolved and 13 patients dislocated (3.8%). There have been 46 deaths in the group with 3 being peri-operative.

There have been 18 re-operations for aseptic loosening. 7 KP plates fractured, 1 cage migrated and 10 rim meshes failed.

Factors associated with aseptic loosening include use of a large rim mesh particularly with an allograft thickness of > 2cm.

We conclude that impaction allografting is a reliable method for acetabular reconstruction. Careful consideration should be given when allograft thickness will be > 2cm and a large rim mesh is required.