Background: Hydroxyapatite (HA) coating is widely used for total hip arthroplasty as it has been suggested to improve implant ingrowth and long-term stability. However, the evidence behind the use of HA in femoral stems is ambiguous.

Methods: We investigated a non-cemented, tapered titanium femoral stem that was available either with or without HA coating. This stem had been used in 3,116 total hip arthroplasties (THAs) in 2,608 patients registered in the Swedish Hip Arthroplasty Register (1992–2007). Kaplan-Meier survival analysis and a Cox regression model including type of coating, age, sex, primary diagnosis, and the type of cup fixation were used to calculate adjusted risk ratios (RR) of the risk for revision for various reasons.

Results: 63.7% of the stems were coated with HA, 36.3% were uncoated. It was found that the investigated HA-coated stem had an excellent 10-year survivorship of 97.7% (95% CI 96.5–98.9), and that the stem without HA coating had a 10-year survivorship of 97.6% (95% CI 96.2–99.0) when revision due to any reason was defined as the endpoint. There was no significant difference between these two groups (p> 0.05, log rank Mantel-Cox). A Cox regression model showed that the presence of HA coating did not significantly influence the risk of stem revision due to any reason (RR 1.3; 95% CI 0.7–2.4), or due to aseptic loosening (RR 1.0; 95% CI 0.3–3.4). The risk for revision due to infection, dislocation, or fracture was also not affected by the presence of HA coating.

Interpretation: Our results show HA coating of this non-cemented tapered stem with excellent 10-year survivorship does not affect the risk for revision. The assumed beneficial effect of HA coating of femoral stems in total hip arthroplasty is thus questionable.

Introduction: There is an increasing interest in surface replacement arthroplasty (SRA) as an alternative to conventional THA (cTHA) in young and active patients. However, there has been considerable variability in reported outcomes. National joint registry reports have shown increased revision rates compared to cTHA. We analysed outcome measured as non-septic revision rate within two years for SRA in the NARA data base (Nordic Arthroplasty Register Association).

Materials and Methods: 1638 SRA and 163802 cTHA with age up to 73 years and a non-fracture diagnosis, operated from 1995 to 2007, were compared using Cox multiple regression including age, gender, diagnosis, nation and prosthesis type with cTHA divided into cemented, uncemented, hybrid and reversed hybrid fixation. Men below 50 years of age (460 SRA and 7185 cTHA) were analysed as a subset. The SRA cohort with a mean follow-up 1,8 years was also analysed with the same method including age, gender, diagnosis, number of performed SRA per hospital and the four most commonly used prosthesis designs. In an additional analysis femoral head diameter was added, reducing the number of cases to 1552. results are presented as relative risk (RR) with 95 % confidence interval(CI).

Results: SRA had a more than twofold increased revision risk compared to cTHA, RR=2,50 (1,67–3,70), which increased to 3,63 (2,42–5,44) when compared with all cemented THA. In the subpopulation of men below 50 years of age, there was no difference between SRA and any of the cTHA cathegories. Within the SRA group RR was reduced by male gender, RR=0,46 (0,25–0,86), in hospital performing > 70 SRA (RR=0,26, 0,11–0,60) and with use of BHR (Birmingham Hip Resurfacing) compared to all other designs (RR=0,27, 0,12–0,61). The size of the femoral head diameter had no significant influence on the early revision rate.

Discussion and Conclusion: Surface replacement arthroplasty has an increased risk of early revision compared to conventional and cemented THA except for men below 50 years of age. There is a learning curve on the hospital level. Cases with secondary osteoarthritis were comparatively few and were mainly caused by pediatric hip disease. SRA might become an alternative for young men, but our follow up is too short to determine if this indication remains in the longer perspective.

Of 960 first-revision total hip replacements (THR) because of deep infection identified in the Swedish Hip Arthroplasty Registry, 16.9% were treated with a permanent implant extraction, while a staged or direct reconstruction revision protocol were employed in 56.2% and 26.9% respectively. The majority of the interventions were performed more than one year after index THR, and the dominating pathogen was coagulase negative staphylococci (CNS). We found a significant shift in types of bacteria over the years (Chi-square test, p smaller than 0.001): an increase in the CNS group and a decrease in Gram-negative aerobes. Patients treated with a permanent resection were generally older (p< 0.001), had more often a previous ipsilateral hip fracture (p< 0.001), and had more frequently Gram-negative infections (p=0.02). No systematic differences in patient characteristics or pathogens were detected between one-stage or two-stage procedures, of which the latter had a median re-implantation time of 2 (range: 0.2–62) months. Of 798 (one- or two-stage) revisions, 60 (7.5%) were revised again due to recurrent infection, with no difference between the two methods, and implying a 10-year survival of 90%; 95% confidence interval (CI95%) 88.2–93.0. Previous surgery for soft-tissue problems (RR 3.2 (CI95% 1.3–7.2)) predicted a worse outcome for one-stage procedures. The prognosis of two-staged revisions improved with increasing re-implantation interval (RR 0.8 (CI95% 0.7–1.0)) per month, and a 6 month interval carried the lowest risk of repeat revision due to infection; RR 0.1 (CI95% 0.0–0.9). Staged revisions in female patients (RR 2.3, (CI95% 0.9–5.7)) and with Staphylococcus aureus infections (RR 2.3 (CI95% 0.9–5.5)) predicted a worse outcome. Ten-year survival with repeat revision for aseptic loosening as end-point was 89% (95%CI 85.7–92.0), but decreased to 79% when all reasons for revision were taken into account (95%CI 75.0–82.3) mainly because of revision for peri-prosthetic fractures.

The results suggest that direct and staged revision protocols can have a good prognosis on a national level, but efforts must be made to counteract periprosthetic fractures and the high incidence of permanent implant extraction in elderly patients.

Background: Hemiarthroplasty of the hip is a common procedure, but information about implants and outcome is scarce. In Sweden the number of hemiarthroplasties has increased from 200 in 1998 to 4181 in 2007.

Material and Methods: Nationwide registration started in 2005. 100% of the hospitals participates, and 96% of the hemi-procedures are registrered. An analysis of 12 245 cases operated 2005–07 is presented.

Results: In the Register the mean age at surgery is 84 years (SD 7.0, 73% female). 93% are operated due to acute fracture and 6% due to failed internal fracture fixation. Cemented fixation has been used in 92% and a posterior approach in about half of the cases (52%). The Lubinus and Exeter stems are most common (41 and 23%). The Austin-Moore design has decreased from 9 to 2% during the study period.

3.2% of the patients (hips) have been reoperated, most commonly because of dislocation. Multiple reoperations are common. Male gender, secondary procedure and uncemented stem are associated with increased reoperation risk with 1.2, 1.7 and 1.8 times (1.2, CI: 1.0–1.6; 1.7, 1.3–2.3; 1.8 1.4–2.5). Use of uncemented fixation resulted in increased risk of reoperation, also with exclusion of uncemented Austin-Moore prostheses (1.8 times, 1.1–2.8).

In a separate analysis of the two most frequent designs, use of bipolar head increased the risk of revision twice (1.4–2.8) compared to unipolar head when adjusting for other risk factors. This may reflect that fitter and more active individuals get a bipolar prosthesis and are more prone to become revised should complications occur or a true increase of complications when using bipolar head. A further analysis is in progress.

Use of dorsal approach (1.6, 1.2–2.2), Austin-Moore (1.8, 1.1–3.1) and Thompson prostheses (1.8, 1.5–2.8) increased the risk of revision because of dislocation.

Summary: When treating fracture patients with hemi-arthroplasty we recommend that a well documented cemented implant with different off-set options should be used via an anterolateral approach. Use of bipolar heads may increase the risk of revision.

Introduction: Up to now comparisons and pooling of data between the Scandinavian arthroplasty registers have been restrained by use of separate and incompatible data systems.

Purpose: To create a common Scandinavian database for hip arthroplasties and to compare demographics and results between the Scandinavian countries.

Materials and methods: For this study we selected primary total hip prostheses (THR) from 1995–2006. A common code set was made, and after de-identification of the patients’ identity, including deletion of the national civil registration numbers, Denmark, Sweden, and Norway delivered data. Kaplan-Meier and Cox multiple regression, with adjustment for diagnosis, age, and gender, were used to calculate prosthesis survival, with any revision as end-point.

Results: 280,201 operations were included (Denmark 69,242, Sweden 140,821, Norway 70,138). Female patients constituted 60% in Denmark and Sweden and 70% in Norway. In Denmark, Sweden, and Norway childhood disease constituted 3.1%, 1.8%, and 8.7% respectively. The posterior approach was used in 91% of cases in Denmark, 60% in Sweden, and 24% in Norway. Cemented THRs were applied in 46% of patients in Denmark, 89% in Sweden, and in 79% in Norway. Resurfacing hips constituted 0.5% or less in all countries.

9,596 of the 280,201 primary THRs, had been revised. Ten-years survival was 91.9% (95% CI: 91.5 – 92.3) in Denmark, 93.9% (95% CI: 93.6–94.1) in Sweden, and 92.6% (95% CI: 92.3–93.0) in Norway.

In Sweden and Norway 23% of revisions were due to dislocation, compared to 34% in Denmark. Replacement of only cup or liner constituted 29% of the revisions in Sweden, 33% in Norway, and 44% in Denmark.

Conclusion: This unique database is now functioning, and has showed differences among the countries concerning demographics, prosthesis fixation, prosthesis survival, and reasons for revisions. The large number of THRs in this database significantly enhances our perspectives for future research, especially in diagnostic- and treatment groups with too small numbers in each separate

Background: Hydroxyapatite (HA) is the main inorganic component of bone, and HA coating is widely used on acetabular cups in hip arthroplasty. It has been suggested that this surface finish improves cup survival, but there is little evidence to support this.

Patients and methods: All patients registered in the Swedish Hip Arthroplasty Register between 1992 and 2007 with an uncemented acetabular implant that was available with or without HA coating were identified. A study population of 8,043 hips with the most common cup types manufactured either with or without HA coating (Harris-Galante, Romanus and Trilogy) was investigated. Kaplan-Meier survival analysis and a Cox regression model including type of coating, age, sex, primary diagnosis, cup type, and type of stem fixation were used to calculate adjusted risk ratios (RR) of the risk for revision.

Results: Kaplan-Meier analysis of all patients indicated a non-significant trend towards inferior performance of the HA-coated cups (p=0.78). When stratified for age, Kaplan-Meier analysis revealed inferior survival of HA-coated cups when compared to non-coated cups in the age group < 50 years (p=0.031). A Cox regression model showed that HA coating was a significant risk factor for cup revision due to aseptic loosening (adjusted RR 1.645; 95% CI 1.315–2.058). Age at primary arthroplasty < 50 years, a diagnosis of paediatric hip disease, a cemented stem, and the Romanus and Harris-Galante cup types were also associated with significantly increased risk for cup revision due to aseptic loosening. There was no difference in the hazard patterns when the risk for revision for any reason was chosen as the endpoint of the analysis. The risk for revision due to infection was not influenced by the type of coating.

Discussion: Our results derived from register data on 8,043 hips indicate that HA coating does not enhance survival of cups when using aseptic loosening as an endpoint. On the contrary, hydroxyapatite coating is a significant risk factor for cup revision due to aseptic loosening when adjusted for other covariates such as age, sex, cup design and primary diagnosis. HA coating cannot be generally recommended as a surface treatment of acetabular cups in younger patients. This conclusion is medically and economically relevant, as many young patients today receive HA-coated cups, and because HA-coated implants are more expensive.

In a previous report from a randomised study we reported excellent fixation and less proximal periprosthetic bone mineral loss around the Epoch design at 2 years follow-up when compared with a solid stem of similar design. We now present the 7 years follow-up.

Forty consecutive patients (20 men, 10 women, mean age 57, 41–74) with non-inflammatory osteoarthritis were randomised to receive either a cementless porous-coated composite stem with reduced stiffness (Epoch) or a cementless stiff stem with a porous coating (Anatomic). Patients were followed for 7 years with repeated evaluations using radiostereometry, DXA, conventional radiography and Harris Hip Score (HHS).

At 7 years 1 stem had been revised (Anatomic) due to late infection. Subsidence and stem rotations were close to zero without any difference between the two groups (p> 0,12). Median wear rates were lower than expected (0.4mm up to 7 years) for both stem designs. At 2 years loss bone mineral density was less in Gruen regions 1, 2, 6 and 7 for the Epoch stems (p< 0.04), but this difference tended to disappear with time. At 7 years only the calcar region (Gruen region 7) had significantly denser bone in the Epoch group (p< 0.001). The HHS scores did not differ (median 98, 51–100). No stem was radiographically loose.

The Epoch stem achieved excellent fixation. Wear rates were low despite use of conventionally gamma-sterilised polyethylene. This low modulus stem had positive effects on early proximal bone remodeling, but this effect decreased with time.

Earlier reports have shown that surface treatment influences the survivorship of tapered hip implants. To assess the role of surface finish for other stem shapes we evaluated three modifications of the Lubinus SP2 stem.

Eighty patients (31 male, 49 female, 68 (46–78 years), 84 hips) with non-inflammatory arthrosis randomly received either stem type: cemented matte (M, standard design), polymethylmetacrylate-coated (PC) or polished (P, collarless). Component fixation and wear were studied with radiostereometric analysis and the bone mineral density was measured around the stem in 40 patients at 6 months, 1, 2 and 5 years.

The polished design showed increased distal migration at 6 months (Mean and range) P: −0.21mm(−0.52 to 0.09), M: −0.07mm (−0.34 to 0.26), PC: −0.03 (−0.18 to 0.18) and at 5 years P:0.49mm (−1.46 to 0.16), M: −0.18mm (−0.80 to 0.33), PC: −0.12mm (−1.40 to 0.12 (p< 0.0001). This increased subsidence occurred inside the cement mantle. The rotations of the stem did not differ (p> 0.4). Neither did the migration and the wear (p> 0.1). After 1 and 2 years the polished stems had lost significantly less bone mineral in Gruen zones 1, 2, 6 and 7 (p 0.004 to 0.03). After 5 years this difference had disappeared. The Harris Hip Scores did not differ.

A polished surface without collar on an anteverted stem design resulted in increased subsidence of the stem inside the cement mantle. The improved bone remodeling around the polished version seemed to be transient.

Introduction: The annual wear rate in polyethylene articulations should be 0.1 mm or less to avoid future osteolysis. Highly Crosslinked polyethylene demonstrates 80–90% wear reduction in hip simulator testing, but the clinical documentation of this new polyethylene is still inadequate. We evaluated the highly crosslink PE in two prospective randomised clinical studies. Patients and Methods: Thirty two patients (12 male, 20 female, 64 hips) with a median age of 48 years (range, 29–70 years) with bilateral primary or secondary arthrosis of the hip received hybrid THA. With liners made of highly cross-link on one side and conventional PE on the other one. Twenty-seven patients in this study have passed 2 years follow up. Further Sixty patients (61 hips) with a median age of 55 years (range, 35–70 years) were randomized to receive either highly crosslink or conventional cemented all PE of the same design. Forty-nine patients have been followed for 3 years. In both studies all patients received Spectron stems with 28mm cobalt-chromium head. Radiostereometric examinations with the patient supine or standing were done at regular intervals. Wear was measured in the supine position from the postoperative week, whereas standing examinations were initiated three months after the operation. Results: The penetration rate was almost identical in the study and control groups in 6 months after the operation. Thereafter the penetration rate levelled out in the 2 groups with highly crosslink PE. At two years the highly crosslink PE liner showed 62% lower proximal penetration and 31% lower total (three-dimensional) penetration when the patients were examined in supine position. The highly crosslink all PE cemented cups showed significantly lower proximal penetration in both position. Discussion: The better wear performance of highly crosslink PE could increase the implant longevity. Longer follow up is needed to evaluate if this new material is associated with less occurrence of osteolysis.

Aims: The aim of this study was to evaluate a highly cross-linked polyethylene WIAM in cemented hip arthroplasty. This new polyethylene has been resistant to wear in laboratory tests. Methods: 60 patients (30 women, 30 men) with a median age of 55 years (35–70) and a median weight 82 kg (47–120) were included. All patients received a Spectron femoral stem with a 28 mm head in chrome-cobalt. The patients were randomised to acetabular cups made of either WIAM (electron beam irradiation 9.5 Mrad) or conventional polyethylene (CP) sterilized in inert atmosphere. Radiostereometric examinations (supine) were done 7 days after the operation and after 3, 6 12 and 24 months. Examinations (standing) were performed at 3, 6 12 and 24 months. The migration of the femoral head centre in relation to the polyethylene marker represented the femoral head penetration. Results:. 43 hip (19 WIAM 24 CP) were available for 24 months FU. There were no differences in cup migrations between the two groups. The mean proximal penetration (supine and standing) was less than 0.2 mm at 24 months in both groups p> 0,06 Conclusions: The femoral head penetration during the first two years may be dominated by creep. There is tendency for lower proximal penetration at standing examination in the WIAM group. Futher studies and longer follow up is necessary until highly crosslink polyethylene can be recommended for general use.

Introduction: In a pioneer study Oonishi et al (1988) found reduced socket wear with the use of polyethylene subjected to high radiation doses. This observation has stimulated the development of a new generation polyethylene. In addition to high radiation doses the plastic is also subjected to various types of heat treatment to reduce the amount of free radicals. The purpose of the present study is to evaluate one of the new highly cross-linked polyethylenes in a randomized controlled study of cemented THA. The hypothesis is that the improved wear resistance will reduce the prevalence of osteolytic lesions with long-term follow-up.

Methods and materials: Patients in clinical and radiographic need of a THR with non-inflammatory osteoarthritis of the hip were randomized in two groups. Group 1 received a cemented Weber cup (Sulzer®, Switzerland) made of highly cross-linked (WIAM) polyethylene, group 2 got a conventional cup. All patients received a cemented Spectron (Smith & Nephew, USA) with a 28mm cobalt-chromium head.

So far 15 patients, (6 male and 9 females) with a median age of 55 years (range 42–62) have been evaluated in group 1 and 14 (9 male and 5 females) with a median age of 55 years (range 45–70) in group 2. The penetration of the femoral heads has so far been measured postoperatively (all hips supine), after 3 month (17 hips supine and standing) and after 6 month (11 hips supine and standing) using radiostereometry.

Results: The median proximal and three-dimensional (3-D) penetration (total wear) 0–6 month (supine position) was almost equal in the two groups. Group 1 had a proximal penetration of 0.08 mm (range 0.00–0.17) and a total penetration of 0.11 mm (range 0.06–0.14). The corresponding values for group 2 were 0,10 mm (0.05–0.21) for proximal penetration and 0.13 mm (0.10–0.16) for total penetration. Between 3 and 6 month the penetration (median values) was 0.04 mm/0.10 mm (proximal/3-D) for group 1 and 0.07 mm/0.12 mm for group 2. With the patients standing we found a proximally migration of the socket (0–6 month) in group 1 of 0,08 mm (−0.07 – 0.21) and 0.12 mm (0.1–0.13) in group 2.

Discussion: Use of a highly cross-linked polyethylene in the socket did not influence the early penetration rate after THR. Early creep of the material is possible explanation.

1-year follow-up on approximately 50% of the patients will be presented at the meeting.