Abstract
Objective
The relationship between the index (2D) to ring finger (4D) is one of the most commonly studied anthropometric measures, which is believed to offer insight into early growth and the foetal environment. This study aimed to determine the relationship between the 2D:4D ratio and the risk of Perthes' disease in children.
Methods
The 2D:4D ratio was measured in 144 cases of Perthes' disease, and 144 controls. Cases and controls were frequency matched for age and sex. Measurements were recorded using a digital venier calliper on the palmar surface of the hand. Logistic regression was undertaken adjusting for age, with stratification for sex.
Results
There was a significant negative association between Perthe's disease and digit ration in the right hand in affected females OR −0.78 (95% CI 0.65 – 0.93). There was no such association in males 0.97 (0.90 – 1.05).
Conclusions
There is a significant association between degree of ‘masculinisation’ and Perthes' disease. This adds evidence to suggest that a significant aetiological component in disease acts prenatally, and may begin to explain the preponderance of disease amongst males.
