IN VITRO EVALUATION OF SURFACE STIFFNESS EFFECTS ON OA-PATIENTS' MSC OSTEOGENIC LINEAGE COMMITMENT

K.E. Wright; R.J.M. Morrison; K.W. Dalgarno; M.A. Birch; A.W. McCaskie

doi:10.1302/1358-992X.95BSUPP_13.BORS2012-023

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IN VITRO EVALUATION OF SURFACE STIFFNESS EFFECTS ON OA-PATIENTS' MSC OSTEOGENIC LINEAGE COMMITMENT

British Orthopaedic Research Society (BORS) Annual Conference

K.E. Wright
R.J.M. Morrison
K.W. Dalgarno
M.A. Birch
A.W. McCaskie

IN VITRO EVALUATION OF SURFACE STIFFNESS EFFECTS ON OA-PATIENTS' MSC OSTEOGENIC LINEAGE COMMITMENT

Wright K, Morrison R, Dalgarno K, Birch M, McCaskie A. IN VITRO EVALUATION OF SURFACE STIFFNESS EFFECTS ON OA-PATIENTS' MSC OSTEOGENIC LINEAGE COMMITMENT. Orthop Procs. 2013;95-B(SUPP_13):23-23. doi:10.1302/1358-992X.95BSUPP_13.BORS2012-023

Wright, K.E., et al. “IN VITRO EVALUATION OF SURFACE STIFFNESS EFFECTS ON OA-PATIENTS' MSC OSTEOGENIC LINEAGE COMMITMENT.” Orthopaedic Proceedings, vol. 95-B, no. SUPP_13, 2013, pp. 23-23., https://doi.org/10.1302/1358-992X.95BSUPP_13.BORS2012-023

Wright, K., Morrison, R., Dalgarno, K., Birch, M., & McCaskie, A. (2013). IN VITRO EVALUATION OF SURFACE STIFFNESS EFFECTS ON OA-PATIENTS' MSC OSTEOGENIC LINEAGE COMMITMENT. Orthopaedic Proceedings, 95-B(SUPP_13), 23-23. https://doi.org/10.1302/1358-992X.95BSUPP_13.BORS2012-023

Wright, K., Morrison, R., Dalgarno, K., Birch, M. and McCaskie, A. (2013) “IN VITRO EVALUATION OF SURFACE STIFFNESS EFFECTS ON OA-PATIENTS' MSC OSTEOGENIC LINEAGE COMMITMENT.” Orthopaedic Proceedings, 95-B(SUPP_13), pp. 23-23. Available at: https://doi.org/10.1302/1358-992X.95BSUPP_13.BORS2012-023

Wright, K.E., R.J.M. Morrison, K.W. Dalgarno, M.A. Birch, and A.W. McCaskie. “IN VITRO EVALUATION OF SURFACE STIFFNESS EFFECTS ON OA-PATIENTS' MSC OSTEOGENIC LINEAGE COMMITMENT.” Orthopaedic Proceedings 95-B, no. SUPP_13 (2013): 23-23. https://doi.org/10.1302/1358-992X.95BSUPP_13.BORS2012-023

Wright K, Morrison R, Dalgarno K, Birch M, McCaskie A. IN VITRO EVALUATION OF SURFACE STIFFNESS EFFECTS ON OA-PATIENTS' MSC OSTEOGENIC LINEAGE COMMITMENT. Orthop Procs. 2013 Mar 1;95-B(SUPP_13):23-23. https://doi.org/10.1302/1358-992X.95BSUPP_13.BORS2012-023

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Abstract

hMSC cultures were prepared from osteoarthritic patients. Silicone elastomer (PDMS) culture surfaces of varying degrees of stiffness (1:10, 1:30 and 1:50 PDMS, tissue culture plastic and glass) were investigated in isolation and in combination with differentiation media. CD marker expressions of ‘stemness’ were investigated. RNA expression changes in OA-hMSCs and non-OA-hMSCs were also investigated for a panel of genes (inclusive of ‘stemness-’ and osteogenic-linked genes, FKBP5 and osteomodulin).

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IN VITRO EVALUATION OF SURFACE STIFFNESS EFFECTS ON OA-PATIENTS' MSC OSTEOGENIC LINEAGE COMMITMENT

British Orthopaedic Research Society (BORS) Annual Conference

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