The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres: THEIR EVALUATION IN AN ANIMAL OSTEOMYELITIS MODEL

Z. Orhan; E. Cevher; L. Mülazimoglu; D. Gürcan; M. Alper; A. Araman; Y. Özsoy

doi:10.1302/0301-620X.88B2.16328

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The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres

THEIR EVALUATION IN AN ANIMAL OSTEOMYELITIS MODEL

Z. Orhan
E. Cevher
L. Mülazimoglu
D. Gürcan
M. Alper
A. Araman
Y. Özsoy

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The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres

Orhan Z, Cevher E, Mülazimoglu L, et al. The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres. J Bone Joint Surg Br. 2006;88-B(2):270-275. doi:10.1302/0301-620X.88B2.16328

Orhan, Z., et al. “The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres.” The Journal of Bone & Joint Surgery British Volume, vol. 88-B, no. 2, 2006, pp. 270-275., https://doi.org/10.1302/0301-620X.88B2.16328

Orhan, Z., Cevher, E., Mülazimoglu, L., Gürcan, D., Alper, M., Araman, A., & Özsoy, Y. (2006). The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres. The Journal of Bone & Joint Surgery British Volume, 88-B(2), 270-275. https://doi.org/10.1302/0301-620X.88B2.16328

Orhan, Z., Cevher, E., Mülazimoglu, L., Gürcan, D., Alper, M., Araman, A. et al. (2006) “The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres.” The Journal of Bone & Joint Surgery British Volume, 88-B(2), pp. 270-275. Available at: https://doi.org/10.1302/0301-620X.88B2.16328

Orhan, Z., E. Cevher, L. Mülazimoglu, D. Gürcan, M. Alper, A. Araman, and Y. Özsoy. “The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres.” The Journal of Bone & Joint Surgery British Volume 88-B, no. 2 (2006): 270-275. https://doi.org/10.1302/0301-620X.88B2.16328

Orhan Z, Cevher E, Mülazimoglu L, Gürcan D, Alper M, Araman A, et al. The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres. J Bone Joint Surg Br. 2006 Feb 1;88-B(2):270-275. https://doi.org/10.1302/0301-620X.88B2.16328

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Abstract

Ciprofloxacin hydrochloride-loaded microspheres were prepared by a spray-drying method using pectin and chitosan. The effects of different polymers and drug ratios were investigated.

The most appropriate carriers were selected by in vitro testing. A rat methicillin-resistant Staphylococcus aureus osteomyelitis model was used to evaluate the effects of the loaded microspheres.

The drug was released rapidly from the pectin carrier but this was more sustained in the chitosan formulation.

Chitosan microspheres loaded with ciprofloxacin hydrochloride were more effective for the treatment of osteomyelitis than equivalent intramuscular antibiotics.

Correspondence should be sent to Dr Z. Orhan; e-mail: zorhan@excite.com

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