O3251 SYNOVIAL FLUID FROM JOINTS CONTAINING COBALT CHROMIUM BEARING SURFACES CAUSE MORE GENETIC DAMAGE THAN FLUID FROM JOINTS MADE OF STAINLESS STEEL OR TITANIUM

Andrew P. Davies; P.A. Campbell; C.P. Case

doi:10.1302/0301-620X.86BSUPP_III.0860360e

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O3251 SYNOVIAL FLUID FROM JOINTS CONTAINING COBALT CHROMIUM BEARING SURFACES CAUSE MORE GENETIC DAMAGE THAN FLUID FROM JOINTS MADE OF STAINLESS STEEL OR TITANIUM

Andrew P. Davies
P.A. Campbell
C.P. Case

O3251 SYNOVIAL FLUID FROM JOINTS CONTAINING COBALT CHROMIUM BEARING SURFACES CAUSE MORE GENETIC DAMAGE THAN FLUID FROM JOINTS MADE OF STAINLESS STEEL OR TITANIUM

Davies AP, Campbell P, Case C. O3251 SYNOVIAL FLUID FROM JOINTS CONTAINING COBALT CHROMIUM BEARING SURFACES CAUSE MORE GENETIC DAMAGE THAN FLUID FROM JOINTS MADE OF STAINLESS STEEL OR TITANIUM. Orthop Procs. 2004;86-B(SUPP_III):360-361. doi:10.1302/0301-620X.86BSUPP_III.0860360e

Davies, Andrew P., et al. “O3251 SYNOVIAL FLUID FROM JOINTS CONTAINING COBALT CHROMIUM BEARING SURFACES CAUSE MORE GENETIC DAMAGE THAN FLUID FROM JOINTS MADE OF STAINLESS STEEL OR TITANIUM.” Orthopaedic Proceedings, vol. 86-B, no. SUPP_III, 2004, pp. 360-361., https://doi.org/10.1302/0301-620X.86BSUPP_III.0860360e

Davies, A. P., Campbell, P., & Case, C. (2004). O3251 SYNOVIAL FLUID FROM JOINTS CONTAINING COBALT CHROMIUM BEARING SURFACES CAUSE MORE GENETIC DAMAGE THAN FLUID FROM JOINTS MADE OF STAINLESS STEEL OR TITANIUM. Orthopaedic Proceedings, 86-B(SUPP_III), 360-361. https://doi.org/10.1302/0301-620X.86BSUPP_III.0860360e

Davies, A. P., Campbell, P. and Case, C. (2004) “O3251 SYNOVIAL FLUID FROM JOINTS CONTAINING COBALT CHROMIUM BEARING SURFACES CAUSE MORE GENETIC DAMAGE THAN FLUID FROM JOINTS MADE OF STAINLESS STEEL OR TITANIUM.” Orthopaedic Proceedings, 86-B(SUPP_III), pp. 360-361. Available at: https://doi.org/10.1302/0301-620X.86BSUPP_III.0860360e

Davies, Andrew P., P.A. Campbell, and C.P. Case. “O3251 SYNOVIAL FLUID FROM JOINTS CONTAINING COBALT CHROMIUM BEARING SURFACES CAUSE MORE GENETIC DAMAGE THAN FLUID FROM JOINTS MADE OF STAINLESS STEEL OR TITANIUM.” Orthopaedic Proceedings 86-B, no. SUPP_III (2004): 360-361. https://doi.org/10.1302/0301-620X.86BSUPP_III.0860360e

Davies AP, Campbell P, Case C. O3251 SYNOVIAL FLUID FROM JOINTS CONTAINING COBALT CHROMIUM BEARING SURFACES CAUSE MORE GENETIC DAMAGE THAN FLUID FROM JOINTS MADE OF STAINLESS STEEL OR TITANIUM. Orthop Procs. 2004 Mar 1;86-B(SUPP_III):360-361. https://doi.org/10.1302/0301-620X.86BSUPP_III.0860360e

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Abstract

Aims: To study the levels of genetic damage caused to a cultured human cell line when cultured with synovial ßuid retrieved from revision arthroplasty joints. Methods: Synovial ßuids were retrieved from revision hip and knee arthroplasty patients with bearings made from Cobalt chrome-on-Cobalt chrome, Cobalt chrome-on-polyethylene, Stainless Steel-on-polyethylene and Titanium-onpolyethylene. Control synovial ßuid was retrieved from primary arthroplasty cases. Synovial ßuid was cultured with human primary þbroblasts for 48 hours in a cell culture system under standardised conditions. The ÔCometñ assay was used with an image analysis system to measure levels of DNA damage caused by the various synovial ßu id samples. Results: Synovial ßuids from Cobalt Chrome-on-Cobalt Chrome and Cobalt Chrome-on-polyethylene joint replacements caused signiþcantly (p< 0.05) more genetic damage than synovial ßuids from Stainless Steel-on-polyethylene and Titanium-on-polyethylene cases. Control synovial ßuid caused minimal change. Conclusions: Different alloys used in Orthopaedic implants are associated with different levels of DNA damage to human cells in vitro. We have no evidence for any long-term health risk to patients with such implants. Further research is needed in this þeld.

Theses abstracts were prepared by Professor Dr. Frantz Langlais. Correspondence should be addressed to him at EFORT Central Office, Freihofstrasse 22, CH-8700 Küsnacht, Switzerland.