O3106 RECYCLING OF AUTOGENOUS BONE AFTER WIDE RESECTION OF TUMORS -PASTEURIZATION? OR IRRADIATION? WHICH IS BETTER?

Abstract

In countries where Confucianism is popular, it is extremely difþcult to get allograft. Twenty seven cases of limb salvage with recycled autogenous bone were performed after wide resection of malignant tumors. Recycling was done in 9 cases with pasteurization and in 18 cases with irradiation. Pasteurization was done in 60¡-30minutes with thermostatic saline bath. Irradiation was performed in sterile plastic jar þlled with saline. 25 Gy radiation was given þrst anteroposteriorly and then another 25Gy posteroanteriorly. Internal þxation was done either with plate and/or intramedullay nail, and in 13 cases, intramedullary packing of bone cement was added. Among 9 pasteurized cases, 5 were intercalary diaphyseal resection, 2 whole bone resection of metatarsals, and 2 prosthesis-pasteurized bone composite arthroplasty. Among 18 irradiated cases, 12 were osteoarticular, and 6 intercalary resections. Follow-up period was 16 to 112 months (mean: 46 months). There was no recycled bone-related local recurrence. Time for union varied greatly.(4 to 14 months). There was no statistical difference in union time between pasteurized and irradiated bone (Wilcoxon rank test). Complications were 9 delayed or non-union, 3 fractures of recycled bone, and 2 cases of separation-resorption of growth plate. Irradiation seems much better than pasteurization because it could preserve mechanical property of articular cartilage and soft tissues such as tendon and capsule. We recommend intraoperative-extracorporeal irradiation as a good substitute for osteoarticular allograft because soft tissue attachment could be saved. Intramedullary packing of bone cement was proved as a good method to enhance the stability of þxation and to prevent fracture.