Abstract
1. Experimental avascular necrosis of the femoral head was produced in rabbits and the histological and radiographic changes were compared.
2. Avascular bone which was not re-ossified or altered in any way showed no change in density to x-rays.
3. Areas of avascular bone which were being repaired by the formation of appositional new bone showed an absolute increase in density in the radiographs. This is apparently due to simple increase in bulk of bone to be penetrated by the x-ray beam. On this basis, increasing density in radiographs of bone suspected of being dead is a sign of increasing re-ossification rather than of increasing necrosis.
4. Re-ossification of dead bone occurred rapidly in the absence of simultaneous resorption of necrotic trabeculae. It is thus suggested that the term "creeping substitution" is misleading and does not reflect accurately the histological findings, at least as they occur in rabbits.
